Functional acrylic acid as stabilizer for synthesis of smart hydrogel particles containing a magnetic Fe3O4 core

Facile fabrication of a magnetic self-healing poly(vinyl alcohol) composite hydrogel

“…12 Magnetic hydrogels are a type of promising functional hydrogel with magnetic properties and can be prepared by two main methods: 13,14 one is to blend pre-synthesized magnetic iron oxide nanoparticles (MIONs) with hydrogels in solution and to crosslink the MIONs with the polymer, the other is in situ generation of MIONs in the preparation of hydrogels. Magnetic hydrogels have been widely used in biological elds such as magnetic resonance imaging, 15 magnetically targeted hyperthermia, 16 drug delivery, 17,18 and immobilization of proteins, 19 which have intrinsic magnetic property and favorable biocompatibility. However, magnetic hydrogel is easily damaged during its application, which may affect the normal use of related products and lead to a short service life.…”

In situ synthesis of magnetic poly(N-tert-butyl acrylamide-co-acrylic acid)/Fe3O4 nanogels for magnetic resonance imaging

“…The bands at 1651-1658 cm À1 and 1546-1560 cm À1 were regarded as amide I (C]O stretching) and amide II (N-H bending), respectively. 26,27 The characteristic bands at 1627-1636 cm À1 and 984-994 cm À1 assigned to C]C of AA and TBA, which could not be found in the spectra of the P(TBA-co-AA) and P(TBA-co-AA)/Fe 3 O 4 nanogels, indicating that the AA and TBA monomers totally formed the P(TBA-co-AA) and P(TBA-co-AA)/Fe 3 O 4 nanogels in the process of polymerization. 28,29 Two characteristic bands for Fe-O stretching observed at 587-593 cm À1 and 464-467 cm À1 were found in the Fe 3 O 4 spectra.…”

A novel route for preparation of multifunctional polymeric nanocarriers for stimuli-triggered drug release

“…As drug carriers, polymer‐based nanoparticles exhibit several advantages, such as reducing the toxicity of drug, increasing the encapsulation efficiency (EE) of hydrophobic drugs in aqueous system, and enhancing the targeting therapy of drug . Thus, researchers have developed novel polymers to provide a smart treatment in human body with active drugs, which can undergo a tremendous and reversible change of morphology in response to the environmental stimuli such as temperature, pH, ionic strength, light, magnetic field, and so on. These specific stimuli responses are used to provide the driving force of the controlled‐release system, for instance, the burst‐release and the pumping effect .…”