Functional abnormalities in symptomatic concussed athletes: an fMRI study

Chen, J.-K.; Johnston, Karen; Frey, Stephen; Petrides, Michael; Worsley, Keith J.; Ptito, Alain

doi:10.1016/j.neuroimage.2003.12.032

Cited by 326 publications

(242 citation statements)

References 37 publications

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“…Mild TBI patients show less activation than controls in the 0-back and the 1-back comparisons, but show a more extensive activation as working memory load increases from 1-back to 2-back, when compared to the non-injured controls, suggestive of less efficient allocation and processing of memory information. Similar differences in functional activation and imaging have been also been reported in concussed athletes who experienced persistent symptoms following a mild TBI (Chen et al, 2004). …”

Section: Pathophysiology Of Tbisupporting

confidence: 73%

Call for an Integrative and Multi-Disciplinary Approach to Traumatic Brain Injury (TBI)

Mansour¹,

Lajiness-O’Neill²

2015

PSYCH

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Much has been gained in our understanding of the psychopathology, assessment, and treatment of TBI. Still lacking is the breadth and depth that an integrative and multi-disciplinary approach to TBI portends. While there is a greater awareness of a need for such a systems-based approach as evidenced by the number of professional organizations and government agencies recently advocating a need for standardization in the collection data in TBI, the application of multi-dimensional approach, and the development novel strategies to deliver prevention, assessment and treatment to large, diverse populations, we are still in the early stages in making this important shift. In the nearer term, there are clinical assessment and interventional programs that can be developed and empirically validated to bring us closer to this integrative, multi-disciplinary ideal. The following review calls for a universal diagnostic classification system for TBI, integration of pathophysiology and pharmacological and rehabilitative therapies, development of treatments addressing disorders comorbid with TBI, and the delivery of assessment and treatment services to large underserved populations.

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Section: Pathophysiology Of Tbisupporting

confidence: 73%

Call for an Integrative and Multi-Disciplinary Approach to Traumatic Brain Injury (TBI)

Mansour¹,

Lajiness-O’Neill²

2015

PSYCH

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“…fMRI has been used to examine functional activation patterns in patients with TBI at all levels of severity in both adults (Cazalis et al, 2006;Christodoulou et al, 2001;Maruishi et al, 2007;McAllister et al, 1999McAllister et al, , 2001Newsome et al, 2007b;Perlstein et al, 2004;Rasmussen et al, 2008;Scheibel et al, 2003Scheibel et al, , 2007Schmitz et al, 2006;Soeda et al, 2005) and children (Lovell et al, 2007;Newsome et al, 2007a;Scheibel et al, 2003). fMRI may also be important in understanding recovery from mild TBI (Chen et al, 2004(Chen et al, , 2007(Chen et al, , 2008Jantzen et al, 2004;Lovell et al, 2007) or in rehabilitation efforts in more severe forms of TBI (Kim, Y. H. et al, 2009;Laatsch, L et al, 2004a,b;Strangman et al, 2005Strangman et al, , 2008. More recently, there has been increasing interest in the concept of what the brain does at rest, and data have been collected with a subject in the scanner, using the BOLD techniques but without any stimulus.…”

Section: Perfusion Imagingmentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

114

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This article identifies emerging neuroimaging measures considered by the inter-agency Pediatric Traumatic Brain Injury (TBI) Neuroimaging Workgroup. This article attempts to address some of the potential uses of more advanced forms of imaging in TBI as well as highlight some of the current considerations and unresolved challenges of using them. We summarize emerging elements likely to gain more widespread use in the coming years, because of 1) their utility in diagnosis, prognosis, and understanding the natural course of degeneration or recovery following TBI, and potential for evaluating treatment strategies; 2) the ability of many centers to acquire these data with scanners and equipment that are readily available in existing clinical and research settings; and 3) advances in software that provide more automated, readily available, and cost-effective analysis methods for large scale data image analysis. These include multi-slice CT, volumetric MRI analysis, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), arterial spin tag labeling (ASL), functional MRI (fMRI), including resting state and connectivity MRI, MR spectroscopy (MRS), and hyperpolarization scanning. However, we also include brief introductions to other specialized forms of advanced imaging that currently do require specialized equipment, for example, single photon emission computed tomography (SPECT), positron emission tomography (PET), encephalography (EEG), and magnetoencephalography (MEG)/magnetic source imaging (MSI). Finally, we identify some of the challenges that users of the emerging imaging CDEs may wish to consider, including quality control, performing multi-site and longitudinal imaging studies, and MR scanning in infants and children.

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“…This reduction has been associated with symptom severity; that is, the more severe the symptoms, the lower the activations observed in the mid-DLPFC. [14][15][16]23,24 Only a limited number of studies have used ERP during the performance of a WM task to further refine our understanding of the cognitive sequelae of MTBI. The ERP is a noninvasive method that represents the electrophysiological signal associated with stimulus perception and cognitive processes during a task.…”

mentioning

confidence: 99%

Evaluating the cognitive consequences of mild traumatic brain injury and concussion by using electrophysiology

Gosselin

Bottari

Chen

et al. 2012

FOC

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Object Mild traumatic brain injury (MTBI), often referred to as concussion when it occurs in sports, produces persistent cognitive problems in at least 15% of patients. Unfortunately, conventional neuropsychological tests usually yield results within normal limits in this population. The main objective of this event-related potential (ERP) study was to understand brain functioning during the performance of a working memory (WM) task in patients who have sustained an MTBI, mostly due to motor vehicle accident or sports concussion. This study also aimed for a better understanding of the association between brain functioning as measured with ERP, behavioral performance on the WM task, postconcussion symptoms, type of injury (that is, sports concussion vs other types), and time since the injury. Methods Forty-four patients with MTBI (7.6 ± 8.4 months postinjury) were tested on a visual WM task with simultaneous recording of ERP, and were compared with 40 control volunteers who were their equivalent for age and sex. Amplitude and latency of frontal (N200 and N350) and parietal (P200 and P300) ERP waves were measured and were compared between groups. Correlation analyses were also performed between ERP characteristics, clinical variables, and behavioral performance. Results A significant group difference was found for behavioral performance on the WM task, in which the MTBI group had a lower percentage of correct answers than the control group (p < 0.05). The patients with MTBI also had smaller amplitudes of both frontal N350 and parietal P300 ERP components when compared with control volunteers (p < 0.05). No changes were found for latency of ERP components. Smaller ERP amplitudes were associated with slower reaction times and worse accuracy on the WM task among patients with MTBI (p < 0.05). Types of injury (that is, sports concussion vs other mechanisms) were not associated with different ERP characteristics. Conclusions Abnormal ERP results are observed in patients after MTBI or sports concussion, even for those in the nonacute stage after their injury. Current standard clinical evaluations most often fail to detect cerebral dysfunction after MTBI, even when patients or athletes report symptoms. Clinicians should be aware that patients with MTBI, including sports concussion, probably have underlying mild but persistent cerebral dysfunctions that require further investigation.

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Functional abnormalities in symptomatic concussed athletes: an fMRI study

Cited by 326 publications

References 37 publications

Call for an Integrative and Multi-Disciplinary Approach to Traumatic Brain Injury (TBI)

Call for an Integrative and Multi-Disciplinary Approach to Traumatic Brain Injury (TBI)

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Evaluating the cognitive consequences of mild traumatic brain injury and concussion by using electrophysiology

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