Functional Ability Correlates with Cognitive Impairment in Parkinson’s Disease and Alzheimer’s Disease

Sabbagh, Marwan N.; Lahti, Tyson; Connor, Donald J.; Caviness, John N.; Shill, Holly A.; Vedders, Linda; Mahant, Padma R.; Samanta, Johan; Burns, R. S.; Evidente, Virgilio Gerald H.; Driver-Dunckley, Erika M; Reisberg, Barry; Bircea, S.; Adler, Charles H.

doi:10.1159/000108340

Cited by 38 publications

(30 citation statements)

References 77 publications

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“…Cognitive dysfunction has been found to have a significant negative effect on the realization of instrumental everyday activities in LOPD patients without dementia [7,8,47]. Therefore, we hypothesized that the cognitive difficulties found in our sample could have adverse effects on complex social, family, and work-related activities, especially when taking into account that these demands might be different due to the age of our patients.…”

Section: Discussionmentioning

confidence: 95%

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Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Seubert-Ravelo

Yáñez-Téllez²,

Salgado–Ceballos³

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: Few studies have described mild cognitive impairment (MCI) and cognitive characteristics in early-onset Parkinson's disease (EOPD). This study describes attention/working memory, language, memory, visuospatial abilities, executive function, and frequency of MCI and dementia in EOPD. Methods: Eighty-one EOPD patients were administered neuropsychological tests and the Beck Depression Inventory. Scores were compared with age/education-appropriate norms and were correlated to years of disease progression and severity of motor symptoms. The frequency of MCI and dementia was determined by the Movement Disorder Society criteria. Results: Thirty-one percent of patients met the MCI criteria, but none had dementia. Commonly affected domains were memory, visuospatial, and executive function. Cognitive dysfunction was not explained by depression or severity of motor symptoms. Conclusion: One third of EOPD patients presented with MCI, which was not associated with the same risk factors as reported in late-onset Parkinson's disease. MCI could have a different prognostic value in EOPD.

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Section: Discussionmentioning

confidence: 95%

“…Studies of LOPD patients have suggested that, even in patients without dementia, cognitive dysfunction has a significant impact on everyday functioning [7,8], QoL of patients [9,10] and caregivers [11], and also represents an increase in economic burden [12]. …”

Section: Introductionmentioning

confidence: 99%

Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Seubert-Ravelo

Yáñez-Téllez²,

Salgado–Ceballos³

et al. 2016

Dement Geriatr Cogn Disord

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“…For example, decline in functional status has been found to correlate with a decline in cognition in patients with Parkinson's disease and Alzheimer's disease. 4 Similarly, a structured strength and balance training program in frail, cognitive impaired elderly long-term care residents improved both functional and cognitive ability. 5 Social isolation has been found to be associated with slower recovery of systolic blood pressure post-task and higher cholesterol level in response to stress.…”

Section: Introductionmentioning

confidence: 98%

A Holistic Approach to Assess Older Adults' Wellness Using e-Health Technologies

Thompson

Demiris

Rue

et al. 2011

Telemedicine and e-Health

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Objectives: To date, methodologies are lacking that address a holistic assessment of wellness in older adults. Technology applications may provide a platform for such an assessment, but have not been validated. We set out to demonstrate whether e-health applications could support the assessment of older adults' wellness in communitydwelling older adults. Materials and Methods: Twenty-seven residents of independent retirement community were followed over 8 weeks. Subjects engaged in the use of diverse technologies to assess cognitive performance, physiological and functional variables, as well as psychometric components of wellness. Data were integrated from various e-health sources into one study database. Correlations were assessed between different parameters, and hierarchical cluster analysis was used to explore the validity of the wellness model. Results: We found strong associations across multiple parameters of wellness within the conceptual model, including cognitive, functional, and physical. However, spirituality did not correlate with any other parameter studied in contrast to prior studies of older adults. Participants expressed overall positive attitudes toward the e-health tools and the holistic approach to the assessment of wellness, without expressing any privacy concerns. Conclusions: Parameters were highly correlated across multiple domains of wellness. Important clusters were noted to be formed across cognitive and physiological domains, giving further evidence of need for an integrated approach to the assessment of wellness. This finding warrants further replication in larger and more diverse samples of older adults to standardize and deploy these technologies across population groups.

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“…PD-MCI is characterized by cognitive impairment that does not interfere significantly with functional independence [4]. However, even in non-demented PD patients, cognitive dysfunction has been shown to have a measurable impact on health-related costs [5], instrumental activities of daily living [6,7] and quality of life [8,9]. Health-related quality of life (HR-QOL) is defined as ‘the perception and evaluation by patients themselves of the impact caused on their life by the disease and its consequences' [10,11].…”

Section: Introductionmentioning

confidence: 99%

Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

Reginold

Duff‐Canning

Meaney

et al. 2013

Dement Geriatr Cogn Disord

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Background/Aims: To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). Methods: HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid baseline were assessed in non-demented PD patients at 6 movement disorder clinics. Results: Among 137 patients, after adjusting for education, gender, disease duration, and Movement Disorder Society Unified Parkinson's Disease Rating Scale total score, MCI was associated with worse scores within the PDQ-39 dimension of communication (p = 0.008). Subjects were divided into tertiles of cognitive decline from premorbid level. Scores in the dimension of stigma were worst in the second tertile of cognitive decline (p = 0.03). MCI was associated with worse social support scores in the second tertile of cognitive decline (p = 0.008). Conclusion: MCI and cognitive decline from premorbid baseline are associated with reduced HR-QOL in communication, stigma, and social support domains. The cognitive decline from premorbid baseline modifies the association between MCI and HR-QOL in PD and knowing both will allow a better appreciation of difficulties patients face in daily life.

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Functional Ability Correlates with Cognitive Impairment in Parkinson’s Disease and Alzheimer’s Disease

Cited by 38 publications

References 77 publications

Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

A Holistic Approach to Assess Older Adults' Wellness Using e-Health Technologies

Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

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