Functional 3D printing: Approaches and bioapplications

Palmara, Gianluca; Frascella, Francesca; Roppolo, Ignazio; Chiappone, Annalisa; Chiadò, Alessandro

doi:10.1016/j.bios.2020.112849

Cited by 96 publications

(64 citation statements)

References 118 publications

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“…3D printing integrates modern digital capture technology, computer-aided design (CAD), numerical control technology, laser or electron beam technology, and the latest achievements in materials science [ 32 ]. There have been significant recent advances in 3D printing technology and its associated software.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiological outcomes in three-dimensional printing assisted revision total hip and knee arthroplasty: a systematic review

et al. 2021

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Background This study investigates whether three-dimensional (3D) printing-assisted revision total hip/knee arthroplasty could improve its clinical and radiological outcomes and assess the depth and breadth of research conducted on 3D printing-assisted revision total hip and knee arthroplasty. Methods A literature search was carried out on PubMed, Web of Science, EMBASE, and the Cochrane Library. Only studies that investigated 3D printing-assisted revision total hip and knee arthroplasty were included. The author, publication year, study design, number of patients, patients’ age, the time of follow-up, surgery category, Coleman score, clinical outcomes measured, clinical outcomes conclusion, radiological outcomes measured, and radiological outcomes conclusion were extracted and analyzed. Results Ten articles were included in our review. Three articles investigated the outcome of revision total knee arthroplasty, and seven investigated the outcome of revision total hip arthroplasty. Two papers compared a 3D printing group with a control group, and the other eight reported 3D printing treatment outcomes alone. Nine articles investigated the clinical outcomes of total hip/knee arthroplasty, and eight studied the radiological outcomes of total hip/knee arthroplasty. Conclusion 3D printing is being introduced in revision total hip and knee arthroplasty. Current literature suggests satisfactory clinical and radiological outcomes could be obtained with the assistance of 3D printing. Further long-term follow-up studies are required, particularly focusing on cost-benefit analysis, resource availability, and, importantly, the durability and biomechanics of customized prostheses using 3D printing compared to traditional techniques.

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Section: Discussionmentioning

confidence: 99%

Clinical and radiological outcomes in three-dimensional printing assisted revision total hip and knee arthroplasty: a systematic review

et al. 2021

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“…Therefore, functional 3D objects with the capacity to respond to biological conditions have been reported [123,124]. One of the main functions of 4D printing is the production of flexible-wearable biosensors with the capacity to detect small metabolites.…”

Section: D Printingmentioning

confidence: 99%

Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

2021

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Natural polymers have been widely used for biomedical applications in recent decades. They offer the advantages of resembling the extracellular matrix of native tissues and retaining biochemical cues and properties necessary to enhance their biocompatibility, so they usually improve the cellular attachment and behavior and avoid immunological reactions. Moreover, they offer a rapid degradability through natural enzymatic or chemical processes. However, natural polymers present poor mechanical strength, which frequently makes the manipulation processes difficult. Recent advances in biofabrication, 3D printing, microfluidics, and cell-electrospinning allow the manufacturing of complex natural polymer matrixes with biophysical and structural properties similar to those of the extracellular matrix. In addition, these techniques offer the possibility of incorporating different cell lines into the fabrication process, a revolutionary strategy broadly explored in recent years to produce cell-laden scaffolds that can better mimic the properties of functional tissues. In this review, the use of 3D printing, microfluidics, and electrospinning approaches has been extensively investigated for the biofabrication of naturally derived polymer scaffolds with encapsulated cells intended for biomedical applications (e.g., cell therapies, bone and dental grafts, cardiovascular or musculoskeletal tissue regeneration, and wound healing).

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“…In the years following the approval of Spritam®, research supporting the use of 3DP to fabricate bespoke pharmaceutical formulations began at an exponential pace [11][12][13][14][15][16][17][18][19][20]. Although 3DP was initially employed to produce simple tablets, the academic 3DP community soon developed the expertise to produce complex structures, polypills, drug-loaded medical devices, and 4D designs [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36].…”

Section: Moving 3dp Of Pharmaceuticals Beyond the Laboratory And Into The Clinicmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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Functional 3D printing: Approaches and bioapplications

Cited by 96 publications

References 118 publications

Clinical and radiological outcomes in three-dimensional printing assisted revision total hip and knee arthroplasty: a systematic review

Clinical and radiological outcomes in three-dimensional printing assisted revision total hip and knee arthroplasty: a systematic review

Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

Disrupting 3D printing of medicines with machine learning

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