Function of Transplanted and Denervated Larynges: II. Arytenoidectomy With Sensory Reinnervation

Silver, Carl E.; Rosen, Richard G.

doi:10.1001/archotol.1974.00780030106005

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…In 1974 Silver and Rosen 7 published their findings with regard to laryngeal sensory reinnervation. At that time, they were performing experiments with laryngeal transplantation, and they asked the question whether an anastomosed Int‐SLN could provide airway protection to prevent pneumonia in these animals.…”

Section: Discussionmentioning

confidence: 99%

“…Even though all of our animals had a period after the first procedure without documented laryngopharyngeal sensation, none had any appreciable symptoms or signs of aspiration. In the sensory reinnervation study by Silver and Rosen, 7 approximately half of their dogs did demonstrate lung consolidation as a result of aspiration; however, these dogs also had total motor denervation and an arytenoidectomy to provide a large airway that allowed decannulation of their tracheotomy tubes. These additional procedures by themselves allow for an increased incidence of aspiration via the loss of mechanical airway protection.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recovery of Laryngeal Sensation After Superior Laryngeal Nerve Anastomosis

Blumin¹,

Ye²,

Berke³

et al. 1999

The Laryngoscope

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recovery of Laryngeal Sensation After Superior Laryngeal Nerve Anastomosis

Blumin¹,

Ye²,

Berke³

et al. 1999

The Laryngoscope

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“…Since the canine larynx is located more cranially in the neck than in humans, deglutition is more likely to cause greater problems in humans after deafferentation. Restoration of a sensory innervation can be achieved by reanastomosis of the SLN main stem [1,19]. Such a restoration of sensory innervation, without restoration of the protective glottic reflex closure, in combination with conditioning and training of the swallowing act might be sufficient to allow swallowing without significant aspiration.…”

Section: Discussionmentioning

confidence: 99%

Reinnervation aspects of laryngeal transplantation

Lith-Bijl

Mahieu

1998

European Archives of Oto-Rhino-Laryngology

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Although restoration of laryngeal function after laryngeal transplantation depends on appropriate reinnervation, non-selective reinnervation procedures result in synkinesis and poor function restoration. This study was performed to test the feasibility of selective reinnervation procedures to restore laryngeal function. Three surgical reinnervation procedures were studied each in a group of ten cats: in group 1 a non-selective procedure in which the recurrent laryngeal nerve (RLN) was cut and reanastomosed; in group 2 selective abductor reinnervation was performed with the phrenic nerve; in group 3 selective abductor reinnervation with the phrenic nerve (PN) was combined with selective adductor reinnervation with the ansa cervicalis. Ten weeks after surgical reinnervation abductor and reflex adductor functions were evaluated with videolaryngoscopy and electromyography. Findings demonstrated that non-selective reinnervation not only gave poor abduction during inspiration but even resulted in paradoxical movement during reflex adduction. Selective abductor reinnervation resulted in good abductor function. Selective adductor reinnervation with the ansa cervicalis brought about muscle tonus in the animals studied but no restoration of reflex adduction. Enhanced activity during respiratory distress gave only slight compromise to the abductor function. In all, selective laryngeal reinnervation with the PN and ansa cervicalis produced good restoration of respiratory laryngeal function. However, deglutition following laryngeal motor and sensory reinnervation with protection of the respiratory tract is probably not sufficient, as in the present group of animals no reflex glottic closure was achieved. More research is required.

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“…Laryngeal transplantation was first studied during the 1960s with the pioneering canine experiments by Ogura, Silver, and Boles 1‐5 . This research has been continued in several centers, including the University of California, Los Angeles (UCLA) 6 .…”

Section: Introductionmentioning

confidence: 99%

Extended Canine Laryngeal Preservation for Transplantation

Kevorkian

Sercarz

et al. 1997

The Laryngoscope

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The goal of successfully transplanting the larynx has motivated researchers since the 1960s. Early laryngeal transplant techniques limited the donor larynx to 45 minutes of ischemia. In this study, a method of prolonged laryngeal preservation is employed in three canines. In vivo cold laryngeal perfusion with University of Wisconsin Solution (UWS) was performed. The larynx was removed and placed into cold storage in 4 degrees C UWS. After 24 hours of storage, the same canines underwent laryngeal reimplantation. The animals were sacrificed 7 days after reimplantation. No evidence of necrosis or vascular insufficiency was identified histologically. The results indicate that canine larynges can be successfully reimplanted after 24 hours of preservation. Future studies will assess the application of this technique to laryngeal transplantation.

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Function of Transplanted and Denervated Larynges: II. Arytenoidectomy With Sensory Reinnervation

Cited by 6 publications

References 5 publications

Recovery of Laryngeal Sensation After Superior Laryngeal Nerve Anastomosis

Recovery of Laryngeal Sensation After Superior Laryngeal Nerve Anastomosis

Reinnervation aspects of laryngeal transplantation

Extended Canine Laryngeal Preservation for Transplantation

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