Function of Submaxillary Gland Following Iatrogenic Damage to Chorda Tympani Nerve

Chilla, R; Brüner, M.; Arglebe, Christian

doi:10.3109/00016487909126399

Cited by 12 publications

(10 citation statements)

References 13 publications

(7 reference statements)

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“…In cases involving CT trauma sustained during otologic surgery, advances in technique have eased the recovery process: Oral sequelae are less frequent when the CT is stretched rather than cut [31-37] and recovery rates following transection are highest when the cut ends are reattached [38, 39]. Still, in these and other cases of CT damage, follow-up taste testing often reveals persistent change and incomplete recovery of function [e.g., 36, 40, 41].…”

Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

Oral sensory nerve damage: Causes and consequences

Snyder

Bartoshuk

2016

Rev Endocr Metab Disord

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Oral sensations (i.e., taste, oral somatosensation, retronasal olfaction) are integrated into a composite sense of flavor, which guides dietary choices with long-term health impact. The nerves carrying this input are vulnerable to peripheral damage from multiple sources (e.g., otitis media, tonsillectomy, head injury), and this regional damage can boost sensations elsewhere in the mouth because of central interactions among nerve targets. Mutual inhibition governs this compensatory process, but individual differences lead to variation in whole-mouth outcomes: some individuals are unaffected, others experience severe loss, and some encounter sensory increases that may (if experienced early in life) elevate sweet-fat palatability and body mass. Phantom taste, touch, or pain sensations (e.g., burning mouth syndrome) may also occur, particularly in those expressing the most taste buds. To identify and treat these conditions effectively, emerging clinical tests measure regional vs. whole-mouth sensation, stimulated vs. phantom cues, and oral anatomy. Scaling methods allowing valid group comparisons have strongly aided these efforts. Overall, advances in measuring oral sensory function in health and disease show promise for understanding the varied clinical consequences of nerve damage.

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Section: Consequences Of Oral Sensory Nerve Damagementioning

confidence: 99%

Oral sensory nerve damage: Causes and consequences

Snyder

Bartoshuk

2016

Rev Endocr Metab Disord

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“…Some patients are asymptomatic, whilst others can have transient or permanent symptoms 1 – 3 . Numerous factors influence which of these three outcomes occurs, the most important being whether the chorda tympani has been sectioned or is grossly intact 2 , 3 , 10 , 19 , 22 , 28 – 30 . Others include the type of surgery, 2 , 31 the age of the patient, 30 , 32 whether the injury is unilateral or bilateral, 7 , 33 and the underlying disease 1 , 2 , 9 , 32 , 34 …”

Section: What Are the Effects Of Chorda Tympani Injury?mentioning

confidence: 99%

“…Chilla et al 28 found that ipsilateral submandibular gland salivary flow was significantly decreased after chorda tympani injury, but not enough to cause symptoms. When the patients were retested four years later, submandibular salivary flow remained diminished, but only in those whose chorda tympani had been divided 29 …”

Section: What Are the Effects Of Chorda Tympani Injury?mentioning

confidence: 99%

Iatrogenic injury of the chorda tympani: a systematic review

2011

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“…The levels of phosphorus and potassium at the operated side were found to be significantly lower compared to those at the healthy side. In the study of Chilla et al [8], the changes in the rate of saliva secretion, and in the concentrations of amylase and protein in saliva were investigated in two groups of patients; the chorda tympani nerve cut group and the chorda tympani excessively stretched group. As in the other studies, the rate of saliva secretion decreased, but not ceased.…”

Section: Discussionmentioning

confidence: 99%

The changes in submandibular gland size and function following chorda tympani section

Uzun¹,

Özkırış

Kubilay

2011

Eur Arch Otorhinolaryngol

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To investigate the effects of chorda tympani section on submandibular gland size and function in the early (postoperative day 7) and late (postoperative month 6) postoperative period by ultrasonography, scintigraphy, and biochemical analysis of the saliva patients with unilateral chronic otitis media. One-hundred and thirty patients (46 males and 84 females) who were ≥16 years of age and diagnosed with unilateral chronic otitis media and for whom type 1 tympanoplasty was indicated in 1st Outpatient Clinic of Kartal Dr. Lutfi Kirdar Training and Research Hospital between August 2004 and February 2007 were enrolled in the study. Of 130 patients, 102 patients who were eligible and gave written approval were included in the study. However, of these patients 99 underwent type 1 tympanoplasty and 3 had a canal down mastoidectomy. In 99 patients, chorda tympani nerves of 16 were cut, but 3 patients had to be excluded due to allergic reactions. Before the operation, bilateral submandibular gland ultrasonography was performed on all patients and the anterior-posterior length, the frontal lateral-medial width (transverse), and the paramandibular depth of both submandibular glands were measured. In scintigraphic examinations, perfusion index (PI), uptake ratio and excretion fraction were measured. Then, in biochemical analysis of the saliva the levels of sodium, potassium, chloride, calcium, magnesium, amylase, and the values of pH and density were assessed by the saliva collection through Wharton duct. In the statistical comparison of operated and healthy side of the patients with respect to these parameters Mann-Whitney U test, and in intragroup analysis Wilcoxon test was used. The volume of the submandibular gland of the operated side was significantly lower compared to the healthy side in postoperative month 6 (P < 0.05). According to the baseline volume of the submandibular gland of the healthy side, the increase in postoperative day 7 and month 6 were found to be statistically insignificant (P > 0.05). According to the baseline PI value, the decreases in the PI value in the postoperative day 7 and postoperative month 6 were statistically significant (P < 0.01). The uptake ratio of the patients was lower in the postoperative day 7 and month 6 than those at the baseline; however, the difference was statistically insignificant (P > 0.05). The excretion fraction values in the postoperative day 7 were significantly lower than the baseline values (P < 0.05), whereas the decrease in the EF values in the postoperative month 6 were statistically insignificant (P > 0.05). In conclusion, the present study was the first in the literature in which three parameters of assessment, such as ultrasonography, scintigraphy, and biochemical analysis, were used to determine the changes in submandibular gland size and function following the chorda tympani section. After chorda tympani section, the volume of submandibular gland decreased in the late postoperative period. Moreover, chorda tympani section led to decrease in the saliva secretio...

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Function of Submaxillary Gland Following Iatrogenic Damage to Chorda Tympani Nerve

Cited by 12 publications

References 13 publications

Oral sensory nerve damage: Causes and consequences

Oral sensory nerve damage: Causes and consequences

Iatrogenic injury of the chorda tympani: a systematic review

The changes in submandibular gland size and function following chorda tympani section

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