Function-Blocking RHAMM Peptides Attenuate Fibrosis and Promote Antifibrotic Adipokines in a Bleomycin-Induced Murine Model of Systemic Sclerosis

Wu, Kitty; Kim, Stephanie M.; Liu, Violet Muhan; Sabino, Alexis; Minkhorst, Kathryn; Yazdani, Arjang; Turley, Eva A.

doi:10.1016/j.jid.2019.11.032

Cited by 10 publications

(12 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…c. Increased COL1A1 expression: Wu et al (2021) found that in BLM-treated mice, NPI-110 and NPI-106 decreased Col1a1 mRNA expression by 11-fold and 14-fold, respectively (P < 0.001). In addition, the authors found that both RHAMMblocking peptides reduced Col1a1-to-Col3a1 ratio to the control ratio (NPI-106) or below the control ratio .…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 98%

“…This protein was initially isolated from fibroblasts and has been expressed in a variety of human tissues, including thymus, lymph node, tonsil, small intestine, colon, skin, bone marrow, placenta, and testis (Chen et al, 2018). Wu et. al.…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

“…2. Wu et al (2021) showed that blocking of the interaction of low-molecular-weight Rhamm resulted in ____________. See following pages for detailed answers DETAILED ANSWERS 1.…”

mentioning

confidence: 99%

“…In this study, Wu et al (2021) utilized two RHAMM-blocking peptides that either bind and isolate low-molecular-weight hyaluronan (LMW-HA) (NPI-106) or bind directly to RHAMM, preventing its association with LMW-HA (NPI-110).…”

mentioning

confidence: 99%

See 3 more Smart Citations

SnapshotDx Quiz: June 2021

Joseph

Chong

2021

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Section: Discussion Of Incorrect Answersmentioning

confidence: 98%

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

“…2. Wu et al (2021) showed that blocking of the interaction of low-molecular-weight Rhamm resulted in ____________. See following pages for detailed answers DETAILED ANSWERS 1.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

SnapshotDx Quiz: June 2021

Joseph

Chong

2021

Journal of Investigative Dermatology

View full text Add to dashboard Cite

“…In addition, the interactions of HA with its various receptors control the effect of HA on cells. For example, the HA-binding protein, named receptor for hyaluronan-mediated motility (RHAMM), has been shown to stimulate the migration of tumor cells [32], fibroblasts [33], and macrophages [34] and to contribute to myofibroblast differentiation [35] in remodeling tissue. Furthermore, the interaction of HA with RHAMM and CD44 was shown to enhance stem cell migration and proliferation [36], but also inflammatory and fibrotic processes [34,37].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of a Hyaluronan-Binding Peptide (P15-1) on Mesenchymal Stem Cells in an Inflammatory Environment

Kirsch

Zhang

Braender-Carr

et al. 2021

IJMS

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) obtained from various sources, including bone marrow, have been proposed as a therapeutic strategy for the improvement of tissue repair/regeneration, including the repair of cartilage defects or lesions. Often the highly inflammatory environment after injury or during diseases, however, greatly diminishes the therapeutic and reparative effectiveness of MSCs. Therefore, the identification of novel factors that can protect MSCs against an inflammatory environment may enhance the effectiveness of these cells in repairing tissues, such as articular cartilage. In this study, we investigated whether a peptide (P15-1) that binds to hyaluronan (HA), a major component of the extracellular matrix of cartilage, protects bone-marrow-derived MSCs (BMSCs) in an inflammatory environment. The results showed that P15-1 reduced the mRNA levels of catabolic and inflammatory markers in interleukin-1beta (IL-1β)-treated human BMSCs. In addition, P15-1 enhanced the attachment of BMSCs to HA-coated tissue culture dishes and stimulated the chondrogenic differentiation of the multipotential murine C3H/10T1/2 MSC line in a micromass culture. In conclusion, our findings suggest that P15-1 may increase the capacity of BMSCs to repair cartilage via the protection of these cells in an inflammatory environment and the stimulation of their attachment to an HA-containing matrix and chondrogenic differentiation.

show abstract