Function and Survival of Jejunal Homo-Transplants in Dogs With and Without Immunosuppressive Treatment

Preston, Frederick W.; Macalalad, Fidel V.; Graber, Ronald; Jackson, Elizabeth J.; Sporn, Joseph

doi:10.1097/00007890-196503000-00009

Cited by 25 publications

(2 citation statements)

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“…Dagegen scheint eine Regeneration der Nerven nach den bis heute vorliegenden Untersuchungen nicht stattzufinden (I, 38, 58). Die klinischen Beobachtungen zeigen jedoch, daß trotzdem eine normale Peristaltik in den Transplantaten möglich ist (1,26,46,53,54,60).…”

Section: Die Funktion Der Dünndarmtransplantateunclassified

Die Dünndarm-Transplantation-Gegenwärtiger Stand und mögliche Zukunft¹

Stauffer¹

1983

Eur J Pediatr Surg

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The transplantation of small intestine is still an experimental therapy. In men, small intestinal transplantation has not yet been successful. Although the technical problems of small intestinal transplantation and monitoring of the grafts have been resolved in animal experiments and a transplantation model has been prepared, survival time of the grafts has been insufficient so far. The introduction of Cyclosporin A as immunosuppressive drug may lead to a dramatic change in the attitude towards small intestinal transplantation. Preliminary results in experimental studies in dogs and piglets with long-term survival of recipients and grafts are very encouraging.

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Section: Die Funktion Der Dünndarmtransplantateunclassified

Die Dünndarm-Transplantation-Gegenwärtiger Stand und mögliche Zukunft¹

Stauffer¹

1983

Eur J Pediatr Surg

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“…A similar technique was used by Kus (1961) and by Preston, Macalalad, Graber, Jackson, andSporn (1969, whereas Barnett, Truett, andStone (1962) placed the homografted segment of small bowel in the abdominal cavity, utilizing the iliac vessels for the vascular anastomosis.…”

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Prolongation of survival of jejunal homografts in dogs treated with azathioprine (imuran)

Taylor

Watson

Walker

et al. 1966

Journal of British Surgery

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An interesting and distinctive group were the cases where histology showed portal fibrosis without definite cirrhosis. The majority of the cases were treated by portacaval shunt of the end-to-end variety.The overall mortality, including short-and longterm mortality, was 27 per cent Of the portacaval group, the total mortality was 29 per cent. The incidence of post-shunt neuropathy syndrome was 23.6 per cent. Postoperative haemorrhagic complications were most marked in the splenorenal and splenectomy groups and were very low in the portacaval shunt group. The cases were followed up over many years. It was seen that in the portacaval shunt group, a large majority of the deaths occurred in the first year. This was not so in the other groups. Haemodynamic studies following portacaval shunt showed that the wedged hepatic venous pressure was reduced by about 6 mm. Hg and the hepatic blood-flow by about 30 per cent. Lowering of the blood-flow by 50 per cent or more was associated with marked neuropathic symptoms.A c k n o w l e d g e m e n t s . -W e are grateful to

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