Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases

Yang, Yuping; Fan, Xiaohui; Liu, Yongjian; Ye, Danyang; Liu, Cen; Yang, Hongliu; Su, Zhijun; Zhang, Yuanyuan; Liu, Yonggang

doi:10.1016/j.bcp.2023.115521

Cited by 7 publications

(2 citation statements)

References 146 publications

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“…Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) is an evolutionarily conserved protein kinase and the most extensively studied member of the dual-specificity tyrosine-regulated kinase (DYRK) family. Studies have shown that it is involved in the development of many diseases, and both low and high expression levels of the DYRK1A protein contribute significantly to disease pathology [ 61 ]. A recent study suggests that elevated plasma levels of DYRK1A might help prevent neurodegenerative diseases [ 62 ], highlighting the potential value of this target in detecting, monitoring, and managing neurodegenerative disorders.…”

Section: Discussionmentioning

confidence: 99%

Identification of potential biomarkers and therapeutic targets related to post-traumatic stress disorder due to traumatic brain injury

Qi,

Huang,

Ren

et al. 2024

Eur J Med Res

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Background Post-traumatic stress disorder (PTSD), a disease state that has an unclear pathogenesis, imposes a substantial burden on individuals and society. Traumatic brain injury (TBI) is one of the most significant triggers of PTSD. Identifying biomarkers associated with TBI-related PTSD will help researchers to uncover the underlying mechanism that drives disease development. Furthermore, it remains to be confirmed whether different types of traumas share a common mechanism of action. Methods For this study, we screened the eligible data sets from the Gene Expression Omnibus (GEO) database, obtained differentially expressed genes (DEGs) through analysis, conducted functional enrichment analysis on the DEGs in order to understand their molecular mechanisms, constructed a PPI network, used various algorithms to obtain hub genes, and finally evaluated, validated, and analyzed the diagnostic performance of the hub genes. Results A total of 430 upregulated and 992 down-regulated differentially expressed genes were extracted from the TBI data set. A total of 1919 upregulated and 851 down-regulated differentially expressed genes were extracted from the PTSD data set. Functional enrichment analysis revealed that the differentially expressed genes had biological functions linked to molecular regulation, cell signaling transduction, cell metabolic regulation, and immune response. After constructing a PPI network and introducing algorithm analysis, the upregulated hub genes were identified as VNN1, SERPINB2, and ETFDH, and the down-regulated hub genes were identified as FLT3LG, DYRK1A, DCN, and FKBP8. In addition, by comparing the data with patients with other types of trauma, it was revealed that PTSD showed different molecular processes that are under the influence of different trauma characteristics and responses. Conclusions By exploring the role of different types of traumas during the pathogenesis of PTSD, its possible molecular mechanisms have been revealed, providing vital information for understanding the complex pathways associated with TBI-related PTSD. The data in this study has important implications for the design and development of new diagnostic and therapeutic methods needed to treat and manage PTSD.

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Section: Discussionmentioning

confidence: 99%

Identification of potential biomarkers and therapeutic targets related to post-traumatic stress disorder due to traumatic brain injury

Qi,

Huang,

Ren

et al. 2024

Eur J Med Res

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“…DYRK1A inhibition stimulates pancreatic β-cell proliferation and cardiomyocyte proliferation following myocardial infarction . In addition, DYRK1A may also be involved in mediating various viral infections (see reviews in refs and − ).…”

Section: Introductionmentioning

confidence: 99%

Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease Drug Candidate

Lindberg,

Deau,

Miege

et al. 2023

J. Med. Chem.

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Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine

Kadyan,

Singh

2024

Pharmacol. Rep

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Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases

Cited by 7 publications

References 146 publications

Identification of potential biomarkers and therapeutic targets related to post-traumatic stress disorder due to traumatic brain injury

Identification of potential biomarkers and therapeutic targets related to post-traumatic stress disorder due to traumatic brain injury

Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease Drug Candidate

Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine

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