“…In response, great efforts have been made for the development of promising alternative options showing broad-spectrum antibacterial activity and nondrug resistance, such as noble metals, metal oxides, carbon-based materials, , and drug-delivery platform. , In particular, carbon quantum dots (CDs), characterized by natural enzyme activity, cell permeability, high stability, excellent biocompatibility and convenient preparation, have created great potential in biolabeling and biomedicine. − Most of these substitution strategies, however, are passive and not suitable for daily and long-term oral use, subject to the natural diffusion of therapeutic materials, limited catalytic efficiency, weak antibacterial properties, , and external physical stimulation (light sources, magnetic fields), − and importantly, do not have the ability to disrupt established mature biofilms …”