Função hepática e renal de frangos de corte alimentados com dietas com aflatoxinas e clinoptilolita natural

Abstract

animais, e foram analisadas as concentrações séricas de cálcio, fósforo, uréia, creatinina, ácido úrico, colesterol, triglicerídeos e gamaglutamil-transferase (GGT). As aflatoxinas diminuem o nível sérico de colesterol. A clinoptilolita diminui o nível sérico do ácido úrico, quando na concentração de 0,25%. As aflatoxinas com 0,25% de clinoptilolita diminuem os níveis séricos da creatinina, do ácido úrico e do colesterol. As aflatoxinas acrescidas por 0,5% de clinoptilolita diminuem os níveis séricos da creatinina e do colesterol e elevam os de gamaglutamil-transferase.Termos para indexação: micotoxina, concentração de minerais, adsorvente, zeolite, nutrição animal. Hepatic and renal functions in broilers fed on diets with aflatoxins and natural clinoptiloliteAbstract -The objective of this study was to evaluate serum minerals and hepatic and renal activities in broiler chicks fed with diets containing aflatoxins and diets with aflatoxins and natural clinoptilolite clay. Five hundred and twenty-eight Ross male broiler chicks were grouped in six treatments with four replications each: T 1 -control: diet free from aflatoxins and clinoptilolite; T 2 -aflatoxins 5 ppm diet; T 3 -0.25% clinoptilolite diet; T 4 -aflatoxins 5 ppm and 0.25% clinoptilolite diet; T 5 -0.5% clinoptilolite diet; and T 6 -aflatoxins 5 ppm and 0.5% clinoptilolite diet. The birds were treated from the 1 st to the 42 nd day of age. Seventy-two birds were slaughtered. Calcium, phosphorus, urea, creatinine, uric acid, cholesterol, triglycerides and gammaglutamil transferase (GGT) were all analyzed in serum. Aflatoxins decrease cholesterol; and 0.25% clinoptilolite decreases serum uric acid and has no effect at 0.5%. Aflatoxins plus 0.25% clinoptilolite diets decrease creatinine, uric acid and cholesterol serum levels. Also aflatoxins plus 0.5% clinoptilolite diets decrease creatinine and cholesterol, but increase GGT serum levels.

Effects of mycotoxin adsorbents in aflatoxin B 1 - and fumonisin B 1 -contaminated broiler diet on performance and blood metabolite

“…Triglyceride levels, in turn, were not influenced by mycotoxins (P>0.05). These data agree with Batina et al (2005) and Maciel et al (2007), who reported no differences in plasma triglyceride content between the positive and negative control containing 5 mg kg −1 of aflatoxins. As regards the functionality of the kidney (Table 4), changes were detected (P<0.01) in serum uric acid and creatinine (P<0.05).…”

“…Therefore, the lowest level of cholesterol found in the NC + 1AD treatment can be indicative that the amount of adsorbent (1 g kg −1 HSCAS) was not sufficient to protect the hepatic system of broilers and the damage caused by mycotoxins may have partly affected the cholesterol biosynthesis, leading to lower production of this metabolite. The results found in this study are similar to that found by Batina et al (2005) and Maciel et al (2007), who also observed a reduction in cholesterol levels in treatments containing aflatoxin. On the other hand, Rauber et al (2013) recorded no differences in serum cholesterol levels when analyzing the effect of fumonisin.…”

“…The creatinine level of treatment NC decreased by 35% compared with treatment PC, a reduction also observed by Batina et al (2005) and Maciel et al (2007), who reported a 30% reduction in creatinine levels when birds were given a feed with 5 mg kg −1 aflatoxin. Nevertheless, the inclusion of mycotoxin associated with adsorbents in the different levels tested promoted the control of serum creatinine compared with the control group (PC).…”

“…The reduction (P<0.05) of about 50% in feed intake of broilers in treatment NC, compared with PC, explains the low uric acid levels found. Batina et al (2005) and Maciel et al (2007) observed a similar reduction using an intoxication of 5 mg kg −1 aflatoxin in broilers. These authors related this decline to possible changes in the hepatic metabolism and the intrahepatic lipid transport, due to the presence of aflatoxin, thus resulting in increased renal excretion of uric acid.…”

“…Gamma-glutamyl transferase acts in the transfer of amino acids and peptides across cell membranes for the protein synthesis, and an increase in its level leads to hepatic damage, maybe through a cholestasis, as observed by Maciel et al (2007) when using 5 mg kg −1 aflatoxin in broiler diets. Triglyceride levels, in turn, were not influenced by mycotoxins (P>0.05).…”