Função endotelial vascular em pacientes com fluxo coronário lento e os efeitos do nebivolol

Güneş, Yılmaz; Gümrükçüoğlu, Hasan Ali; Akdağ, Serkan; Şimşek, Hakkı; Şahin, Musa; Tuncer, Mustafa

doi:10.1590/s0066-782x2011005000105

Cited by 11 publications

(4 citation statements)

References 31 publications

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“…A recent study showed that aspirin did not improve brachial flow-mediated dilatation (FMD), an index of endothelial function in patients with SCF. However, patients treated with aspirin were free of angina after treatment of SCF [35]. In this study, use of aspirin was significantly higher in the SCF group than the control group.…”

Section: Discussionmentioning

confidence: 67%

Plasma lipoprotein (a) levels in patients with slow coronary flow

Yücel

Doğan²,

Altınbaş³

et al. 2013

pwki

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IntroductionSlow coronary flow (SCF) is a microvascular disorder characterized by delayed opacification of coronary vessels with normal coronary angiogram. It may be due to endothelial dysfunction and diffuse atherosclerosis. Lipoprotein(a) [Lp(a)] is related to cardiovascular events. Plasma Lp(a) levels have not been studied previously in SCF patients.AimWe investigated plasma Lp(a) and fibrinogen levels, and their relation to coronary flow rate in patients with SCF.Material and methodsThis cross-sectional study included 50 patients with SCF and 30 age- and sex-matched controls who had normal coronary arteries and normal flow. Coronary flow rates of patients and controls were counted with the thrombolysis in myocardial infarction (TIMI) frame count. Plasma Lp(a) and fibrinogen levels were measured in SCF patients and controls, with routine biochemical tests.ResultsThere were no significant differences between the two groups with respect to plasma Lp(a) (21 mg/dl vs. 14 mg/dl, p = 0.11) and fibrinogen (278 mg/dl vs. 291 mg/dl, p = 0.48) levels. The TIMI frame count was not correlated with plasma Lp(a) (r = 0.13, p = 0.25) or fibrinogen (r = –0.14, p = 0.28) levels.ConclusionsOur results show that there is no significant association between SCF and Lp(a) and fibrinogen levels.

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Section: Discussionmentioning

confidence: 67%

Plasma lipoprotein (a) levels in patients with slow coronary flow

Yücel

Doğan²,

Altınbaş³

et al. 2013

pwki

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“…Based on these three previous studies, the pathophysiological mechanism of CSF is still unclear and it seems impossible to explain the CSF process by only one mechanism. However, among all the suggested underlying mechanisms, endothelial dysfunction is the most widely recognized [ 13 – 15 ]. Meanwhile, numerous studies have indicated that miRNA-22 plays a key role in regulating endothelial function.…”

Section: Discussionmentioning

confidence: 99%

“…However, the role of miRNAs in CSF is still not clear. Although the pathophysiological mechanism of CSF remains unclear, endothelial dysfunction is widely considered to play an important role [ 13 – 15 ]. Numerous studies have indicated that miRNA-22 plays a key role in regulating endothelial function [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

miRNA-22 as a Candidate Diagnostic Biomarker for Coronary Slow Flow

Chen

Wang

2020

Cardiology Research and Practice

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Background. Coronary slow flow (CSF) refers to the phenomenon of delayed distal flow in the absence of lesions detected on coronary angiography. Although the detection rate of CSF has been increasing in clinical practice, early diagnosis is difficult and the factors contributing to this condition remain unclear. Given the increasing demonstration of the roles of microRNAs (miRNAs) in disease and as diagnostic biomarkers, the aim of this study was to analyze the expression of serum miRNA-22 in patients with CSF detected using coronary angiography and its diagnostic efficacy. Methods and Results. A retrospective analysis including 44 patients with CSF and 42 patients with normal coronary flow (control group) was conducted. Additionally, all included patients either did not have visually estimated coronary artery stenosis or had <50% stenosis. Plasma samples were collected from patients in these two groups, and the levels of miRNA-22 were detected. The receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic efficiency of serum miRNA-22 in the context of CSF. Results. The expression of serum miRNA-22 was significantly higher in the CSF patients than in the control subjects (P < 0.0001). The area under the ROC curve for miRNA-22 in diagnosing CSF was 0.8293 (95% confidence interval: 0.7313–0.9272), with a sensitivity of 75.0% and specificity of 88.1%. Conclusions. The expression of serum miRNA-22 in CSF is upregulated compared to that in subjects with normal coronary flow and shows relatively high clinical diagnostic efficiency, suggesting a new potential biomarker for the early diagnosis of CSF.

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“…Patients with ischemic coronary artery diseases typically have coronary artery stenosis, although approximately 10–20% of patients with angina pectoris have normal coronary artery, and most of these patients are syndrome X that showed slow coronary flow [1], [2]. In addition, patients with chest pain but with an intact coronary artery stenosis were reported [3], [4].…”

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confidence: 99%

Pulmonary vein thrombosis is associated with chest pain in patients without coronary artery stenosis

Takeuchi¹

2015

IJC Heart & Vasculature

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Função endotelial vascular em pacientes com fluxo coronário lento e os efeitos do nebivolol

Cited by 11 publications

References 31 publications

Plasma lipoprotein (a) levels in patients with slow coronary flow

Plasma lipoprotein (a) levels in patients with slow coronary flow

miRNA-22 as a Candidate Diagnostic Biomarker for Coronary Slow Flow

Pulmonary vein thrombosis is associated with chest pain in patients without coronary artery stenosis

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