Fumschleicherine, an alkaloid of Fumaria schleicheri

Kiryakov, H. G.; Mardirossian, Z.H.; Hughes, Donald W.; MacLean, David B.

doi:10.1016/s0031-9422(00)91075-6

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…The NMR and MS data for entonalactam C suggested that 3 was hydroxylated at C-8, and thus contained a hemiaminal functional group. These data were consistent with other natural products such as those belonging to fumschleicherine (Kiryakov et al, 1980), and fumadensine (Abu Zarga et al, 1987), which both contain hemiaminal moieties. For example, comparison of the 13 C NMR chemical shifts at C-1 and C-8 of the 5 membered lactam ring of entonalactam C with fumschleicherine (Kiryakov et al, 1980), showed only minor differences of 2.6 and 3.5 ppm, respectively.…”

Section: Resultssupporting

confidence: 89%

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

et al. 2015

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Section: Resultssupporting

confidence: 89%

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

et al. 2015

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“…Berbines: Coptisine (2) Protopines: Allocryptopine (2)(3)(4), cryptopine (4), protopine (2)(3)(4)(5)(6)(7)(8)(9) Benzophenanthridines: Chelerythrine (2,3,9), chelirubine (2), sanguinarine (2)(3)(4)9), dihydrosanguinarine…”

mentioning

confidence: 99%

(-)-Corydalisol: a New Secoberbine Alkaloid

Gözler¹,

Önür²,

Minard³

et al. 1983

J. Nat. Prod.

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“…Such a moiety was previously found in fumschleicherine and fumadensine alkaloids isolated from Fumaria spp. (Kiryakov et al 1980;Zarga et al 1987). The three compounds were isolated as a racemic mixture and none of them showed promising antimalarial activity when tested in-vitro for growth inhibitory activity against Plasmodium falciparum 3D7 malaria parasites, thus, chiral separation was not undertaken.…”

Section: Phthalimidines From Fungal Species Of the Order Xylariales P...mentioning

confidence: 99%

Fungal phthalimidines-chemodiversity, bioactivity and biosynthesis of a unique class of natural products

El Maddah,

Nazir,

Ahmad

et al. 2024

Phytochem Rev

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A wide range of natural products important for the engineering and drug design of pharmaceuticals comprise largely of nitrogen-based heterocycles. Fungal natural products have proven to be a rich source of the industrially-important molecules, many of which are promising drug leads. Although, natural products containing a phthalimidine core tends not to be given distant classification, but compounds containing these structures exhibit antimicrobial, anthelmintic, antimalarial and insecticidal activities, and are among the potential target for discovering new drug candidates. Intriguingly, these are primarily isolated from fungal sources and to a very lesser extent from plants or bacteria. This review surveys fungal-derived phthalimidine metabolites published until the end of 2022, isolated from both terrestrial and aquatic or marine sources with emphasis on their unique chemistry, bioactivities, biogenesis and taxonomic classification. Their unique chemistry and diverse bioactivities (including antiviral, antiproliferative, antioxidant and antimicrobial) provide a chemical library with high medicinal potential, representing a treasure trove for synthetic chemists. Graphical Abstract

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Fumschleicherine, an alkaloid of Fumaria schleicheri

Cited by 11 publications

References 5 publications

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

(-)-Corydalisol: a New Secoberbine Alkaloid

Fungal phthalimidines-chemodiversity, bioactivity and biosynthesis of a unique class of natural products

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