Fumonisin-Exposure Impairs Age-Related Ecological Succession of Bacterial Species in Weaned Pig Gut Microbiota

Mateos, I.; Combes, Sylvie; Pascal, Géraldine; Cauquil, Laurent; Barilly, Céline; Cossalter, Anne Marie; Laffitte, Joëlle; Botti, Sara; Pinton, Philippe; Oswald, Isabelle P.

doi:10.3390/toxins10060230

Cited by 37 publications

(32 citation statements)

References 54 publications

(72 reference statements)

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“…Likewise, OTUs classified as Veillonellaceae and Lachnospiraceae were also observed with high abundances in HA ewes, which is in line with a recent study where high abundances of these bacteria were also found in cattle grazing toxic endophyte-infected tall fescue ( 8 ). Bacterial community structure has been shown to be affected by other mycotoxins (i.e., deoxynivalenol or fumonisin) in previous studies ( 30 , 31 ). Therefore, these three rumen bacterial families may be associated with mycotoxin degradation.…”

Section: Discussionmentioning

confidence: 83%

Endophyte-Infected Tall Fescue Affects Rumen Microbiota in Grazing Ewes at Gestation and Lactation

et al. 2020

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Tall fescue ( Schedonorus arundinaceus ) is a cool-season perennial grass that is widely used as a forage for many livestock species including sheep. An endophyte ( Neotyphodium coenophialum) in tall fescue produces ergot alkaloids that enhance plant survival but produce toxicosis in animals. The objective of this study was to investigate the rumen microbiota from gestation and lactation in ewes grazing tall fescue pastures with high (HA) or moderate (MA) levels of endophyte infection, and their relationship with serum parameters. Data were collected at the beginning of the study (d1), the week before initiation of lambing (d51), and at the end of the trial (d115). The rumen microbiota was evaluated using 16S rRNA gene sequencing. Ewes grazing HA had greater serum non-esterified fatty acid (NEFA) ( P = 0.024) levels compared with ewes in MA pasture at d115. Both the number of observed OTUs and Shannon diversity index tended ( P = 0.08, P = 0.06) to be greater for HA than for MA on d115. At the genus level, Prevotella relative abundance increased with time in both MA and HA (on d1, d51, and d115: 15.17, 25.59, and 24.78% in MA; 14.17, 18.10, and 19.41% in HA). Taxa unclassified at the genus level including (unclassified) Lachnospiraceae, Coriobacteriaceae , and Veillonellaceae exhibited higher abundances in HA at d51 (3.72, 2.07, and 11.22%) compared with MA (2.06, 1.28, and 7.42%). The predictor microbiota for HA and MA were identified by a random forest classification model. The HA predictors included bacteria associated with unclassified Coriobacteriaceae and Ruminococcaceae . Other OTUs classified as Prevotella and Clostridiales could be microbial predictors for MA. The OTUs classified as Prevotella and Lachnospiraceae were negatively correlated with serum concentration of prolactin. Negative correlations with NEFA were observed in the microbiota such as species affiliated to unclassified Clostridiales and Prevotella . OTUs classified as Bacteroidetes and Coriobacteriaceae exhibited a positive correlation with NEFA. Our study confirmed that the rumen microbiota populations were affected by high levels of toxins in endophyte-infected tall fescue and were associated with host hormone and energy metabolism.

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Section: Discussionmentioning

confidence: 83%

Endophyte-Infected Tall Fescue Affects Rumen Microbiota in Grazing Ewes at Gestation and Lactation

et al. 2020

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“…It has been reported that the abundance of the genus Ruminococcus gauvreauii was negatively associated with weaning body weight in meat rabbits [34]. Ruminococcus gauvreauii and Ruminococcaceae UCG-005 are positively correlated with chronic inflammation, metabolic diseases, and mycotoxin exposure in rats and weaning piglets [35,36]. In the present study, we found that the abundance of the [Ruminococcus] gauvreauii group, Ruminococcaceae UCG-005, and Ruminococcaceae UCG-008 were positively correlated with diarrhea incidence and negatively correlated with growth performance (BW, ADG, and AFI).…”

Section: Discussionmentioning

confidence: 99%

Bacillus licheniformis-Fermented Products Reduce Diarrhea Incidence and Alter the Fecal Microbiota Community in Weaning Piglets

Hung

Cheng

Chen

et al. 2019

Animals

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Simple Summary: Antibiotics have been commonly used worldwide as growth promoters and for prophylactic treatment of diarrhea in weaning piglets. However, The European Union has banned the use of antibiotic growth promoters in animal production. Therefore, finding alternative solutions for preventing diarrhea in weaning piglets is urgent. Modulation of gut microbiota composition by probiotics has a beneficial effect on animal health. In this study, we assessed the effects of Bacillus licheniformis-fermented products on diarrhea incidence and the fecal microbiome composition in weaning piglets. Results showed that B. licheniformis-fermented products could improve diarrhea incidence and the fecal microbiota community in weaning piglets. These findings indicate that B. licheniformis-fermented products have the potential for development as feed additives and use as possible substitutes for antibiotics to prevent postweaning diarrhea in the pig industry.Abstract: Prophylactic use of antibiotics in-feed has been effective in decreasing the incidence of diarrhea in weaning piglets. However, the overuse of antibiotics as prophylactic or therapeutic agents in animal feed leads to the evolution of drug-resistant bacteria and antibiotic residues in pigs. This study investigated the effects of Bacillus licheniformis-fermented products on diarrhea incidence and the fecal microbial community in weaning piglets. A total of 120 crossbred piglets with an average initial body weight of 9.87 ± 1.43 kg were randomly allotted to four dietary treatments consisting of three replicate stalls with 10 piglets in each. The dietary treatments comprised a basal diet as control, control plus 1 g/kg or 4.5 g/kg of B. licheniformis-fermented products, and control plus 30 mg/kg antibiotics (bacitracin methylene disalicylate). Results showed that 4.5 g/kg of B. licheniformis-fermented product supplementation significantly reduced diarrhea incidence in weaning piglets. Principal coordinate analysis and a heatmap of species abundance indicated distinct clusters between the groups treated with antibiotics and B. licheniformis-fermented products. The bacterial richness and evenness in the feces decreased in weaning piglets fed 1 g/kg of B. licheniformis-fermented products and antibiotics. The abundance of the genera [Ruminococcus] gauvreauii group, Ruminococcaceae UCG-005, and Ruminococcaceae UCG-008 in the feces decreased in weaning piglets fed B. licheniformis-fermented products or antibiotics. The average abundance of the genus Prevotella 9 in the feces was positively correlated with the concentration Animals 2019, 9, 1145 2 of 15 of B. licheniformis-fermented products and negatively correlated with the diarrhea incidence in weaning piglets. Furthermore, the average abundance of the genus Prevotella 9 in the feces was positively correlated with the growth performance of weaning piglets. These results demonstrate that B. licheniformis-fermented products can improve diarrhea incidence and fecal microflora composition in weaning piglets.

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“…In addition, FB 1 is the main component of Fums, in terms of the toxicity among all the members of Fums . Mateos et al found that FB 1 damaged age‐associated ecological succession of bacterial species in the gut microbiota of weaned pig. Also, it was illustrated that Fums could induce serious toxic effects on the livers, kidneys, lungs, and other organs in pigs .…”

Section: Introductionmentioning

confidence: 99%

Fumonisin B₁ damages the barrier functions of porcine intestinal epithelial cells in vitro

Chen

et al. 2019

J Biochem & Molecular Tox

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Fumonisin-Exposure Impairs Age-Related Ecological Succession of Bacterial Species in Weaned Pig Gut Microbiota

Cited by 37 publications

References 54 publications

Endophyte-Infected Tall Fescue Affects Rumen Microbiota in Grazing Ewes at Gestation and Lactation

Endophyte-Infected Tall Fescue Affects Rumen Microbiota in Grazing Ewes at Gestation and Lactation

Bacillus licheniformis-Fermented Products Reduce Diarrhea Incidence and Alter the Fecal Microbiota Community in Weaning Piglets

Fumonisin B₁ damages the barrier functions of porcine intestinal epithelial cells in vitro

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Fumonisin-Exposure Impairs Age-Related Ecological Succession of Bacterial Species in Weaned Pig Gut Microbiota

Cited by 37 publications

References 54 publications

Endophyte-Infected Tall Fescue Affects Rumen Microbiota in Grazing Ewes at Gestation and Lactation

Endophyte-Infected Tall Fescue Affects Rumen Microbiota in Grazing Ewes at Gestation and Lactation

Bacillus licheniformis-Fermented Products Reduce Diarrhea Incidence and Alter the Fecal Microbiota Community in Weaning Piglets

Fumonisin B1 damages the barrier functions of porcine intestinal epithelial cells in vitro

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Fumonisin B₁ damages the barrier functions of porcine intestinal epithelial cells in vitro