Fumaric Acid Esters in Dermatology

Lee, Katrina; Alcaráz, A lberto J Córdova; Soung, Jennifer

doi:10.1007/978-3-319-66884-0_20

Cited by 2 publications

(4 citation statements)

References 58 publications

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“…Fumaric acid esters (FAEs) regulate mitochondrial function and are associated with the regulation of the glutathione redox cycle [ 32 , 35 ]. Depending on the dose and type of fumarate, FAEs can decrease or enhance cell viability, mitochondrial oxygen consumption and glycolysis rates [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fumaric acid, in the concentration range we applied, has a well-established role as an antioxidant in both pure systems and cell cultures [ 30 , 31 , 32 ]. Thus, it is highly probable that it exerts its protective effect through the alleviation of oxidative stress and the restoration of the redox balance in frozen–thawed buck spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

“…They have strong ROS scavenging properties and exhibit anti-inflammatory, immunomodulatory and chemopreventive effects on cells, tissues and organs [ 30 , 31 ]. FA and FAEs affect the glutathione redox cycle, thereby exerting their antioxidant effects [ 32 ]. To regulate the gene transcription of antioxidant enzymes, FAEs use the nuclear factor (erythroid-derived 2)-related factor 2 (NRF2) genetic pathway [ 33 , 34 ], thereby increasing intracellular reduced glutathione (GSH) and regulating cytokine formation, cell proliferation and apoptosis [ 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Post-Thaw Parameters of Buck Semen Quality after Soy Lecithin Extender Supplementation with Fumaric Acid

Saratsi,

Samartzi,

Panagiotidis

et al. 2023

Veterinary Sciences

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The supplementation of cryopreservation media with antioxidants improves the post-thaw quality and fertilizing ability of spermatozoa. To maximize the fertility of frozen–thawed buck spermatozoa, further research is required to overcome obstacles that have yielded controversial results and standardize protocols. In the present work, the effect of adding fumaric acid (a well-described antioxidant) to a soy lecithin semen extender on certain quality parameters of spermatozoa following freezing and thawing was examined for the first time. Five sexually mature Skopelos bucks were used, and ejaculates were collected with an artificial vagina. The semen samples (98 samples, five replicates) were diluted (400 × 106 spermatozoa/mL) with OviXcell®, supplemented with fumaric acid (0 mM, 2.15 mM, 10 mM or 30 mM), equilibrated (5 °C; 3 h), packed (0.5 mL straws), frozen and stored (−196 °C) until further processing. After thawing, the spermatozoa total and progressive motility (CASA), viability (eosin–nigrosin), membrane functional integrity (HOST), acrosome integrity (SpermBlue®) and mitochondrial function (Rhodamine-123/SYBR-14/PI) were evaluated. Statistical analysis was performed with one-way ANOVA, followed by Duncan’s test; significance was set at 0.05. The addition of 2.15 mM fumaric acid improved (p < 0.05) spermatozoa viability, membrane functional integrity, acrosome integrity and mitochondrial function compared to all other concentrations. The addition of 30 mM fumaric acid decreased (p < 0.05) spermatozoa viability and mitochondrial function compared to all other concentrations. These results indicate a beneficial effect of a 2.15 mM fumaric acid addition to a soy lecithin extender on post-thaw buck spermatozoa quality. Further research is required to evaluate the in vivo fertility of frozen–thawed buck spermatozoa treated with fumaric acid, as well as to elucidate the mechanism of action of fumaric acid in spermatozoa.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Post-Thaw Parameters of Buck Semen Quality after Soy Lecithin Extender Supplementation with Fumaric Acid

Saratsi,

Samartzi,

Panagiotidis

et al. 2023

Veterinary Sciences

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“…Fumaric acid is an α,β‐unsaturated dicarboxylic acid, playing an important role in the Krebs cycle. Its esters, used for the treatment of psoriasis, are available in two oral forms: Fumaderm®, a defined mixture of several forms of fumaric acid esters (FAE) and salts, launched by Fumapharm in 1994 in Germany, and Skilarence®, which contains pure dimethyl fumarate (DMF; Figure 5) and was approved by the European Medicines Agency (EMA) in 2017 and launched by Almirall in the UK 88,89 . Other than dermatology, DMF is also sold by Biogen for the treatment of multiple sclerosis (Tecfidera®).…”

Section: Research Strategy For Nrf2 Modulators In Skin and Scalp Carementioning

confidence: 99%

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

2022

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The skin is the organ that is most susceptible to the impact of the exposome.Located at the interface with the external environment, it protects internal organs through the barrier function of the epidermis. It must adapt to the consequences of the harmful effects of solar radiation, the various chemical constituents of atmospheric pollution, and wounds associated with mechanical damage: oxidation, cytotoxicity, inflammation, and so forth. In this biological context, a capacity to adapt to the various stresses caused by the exposome is essential; otherwise, more or less serious conditions may develop accelerated aging, pigmentation disorders, atopy, psoriasis, and skin cancers. Nrf2-controlled pathways play a key role at this level. Nrf2 is a transcription factor that controls genes involved in oxidative stress protection and detoxification of chemicals. Its involvement in UV protection, reduction of inflammation in processes associated with healing, epidermal differentiation for barrier function, and hair regrowth, has been demonstrated. The modulation of Nrf2 in the skin may therefore constitute a skin protection or care strategy for certain dermatological stresses and disorders initiated or aggravated by the exposome. Nrf2 inducers can act through different

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Fumaric Acid Esters in Dermatology

Cited by 2 publications

References 58 publications

Post-Thaw Parameters of Buck Semen Quality after Soy Lecithin Extender Supplementation with Fumaric Acid

Post-Thaw Parameters of Buck Semen Quality after Soy Lecithin Extender Supplementation with Fumaric Acid

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

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