Fulminating parapontine epidermoid carcinoma in a four-year-old boy

Wong, Song W.; Ducker, Thomas B.; Powers, James M.

doi:10.1002/1097-0142(197603)37:3<1525::aid-cncr2820370341>3.0.co;2-w

Cited by 37 publications

(10 citation statements)

References 11 publications

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“…18 A survey of the literature regarding cases of squamous cell carcinoma of the brain, shows the patients range in age from 4 to 74 years old, with many of them in the fifth and sixth decades. The four-year-old boy described by Wong et al 20 is exceptional. There is a male predominance of two to one.…”

Section: Discussionmentioning

confidence: 88%

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Primary squamous cell carcinoma of the brain. A rare autopsy case

Shirabe¹,

Fukuoka²,

Watanabe

et al. 2003

Neuropathology

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In the present study, a rare autopsy case of primary squamous cell carcinoma of the brain is described. The patient was a 49-year-old man who showed brainstem symptoms and signs. These included oculomotor, abducens and facial palsies, dysphagia, dysarthria, and long tract signs such as quadriplegia with Babinski's signs during the 3-year and 6-month course of his illness. Neuropathologically, poorly differentiated squamous cell carcinoma was seen in the pons, medulla oblongata, part of the midbrain and spinal cord, the base of the cerebellum, the hypothalamus, the optic chiasm, and the left parahippocampal gyrus. The base of the pons and medulla oblongata were extensively destroyed by tumor cells. The relevant literature regarding primary squamous cell carcinomas of the brain was reviewed, and the characteristic features of this rare condition were discussed.

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Section: Discussionmentioning

confidence: 88%

“…The four‐year‐old boy described by Wong et al. 20 is exceptional. There is a male predominance of two to one.…”

Section: Discussionmentioning

confidence: 91%

Primary squamous cell carcinoma of the brain. A rare autopsy case

Shirabe¹,

Fukuoka²,

Watanabe

et al. 2003

Neuropathology

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“…Epidermoid cysts comprise about 1% of brain tumors and have only been reported in eight autopsies published in international journals [9][10][11][12][13][14][15][16]. The ages of the subjects in these reports range from 4-66 years (median: 36 years), which is relatively young, and there were six males and two females.…”

Section: Discussionmentioning

confidence: 99%

Two Autopsy Cases Assessing the Association of Rare Tumors Adjacent to the Sella turcica with Cause of Death and a Review of the Literature

Ishikawa¹,

Morioka²,

Potente³

2017

IJFP

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“…These five groups include initial malignant transformation of an epidermoid cyst, malignant transformation from a remnant epidermoid cyst, malignant transformation with leptomeningeal carcinomatosis, squamous cell carcinoma arising from other benign cysts, other malignancies arising from benign cysts. Transformation of an epidermoid cyst has been described in the vast majority of such cases [19, 20]. There have been only few case reports of de novo intra-cranial SCC [21, 22] and malignant transformation of other non-neoplastic epithelial cysts.…”

Section: Discussionmentioning

confidence: 99%

Non-metastatic squamous cell carcinoma within a Rathke’s cleft cyst

et al. 2015

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Primary intracranial and sellar squamous cell carcinoma is an extremely rare entity, usually caused by malignant transformation of epidermoid cysts, or very rarely other non-malignant epithelial cysts. Malignant transformation of a Rathke’s cleft cyst has never been described. We present a 49-year-old male patient who presented with a 3-month history of progressive frontotemporal headaches. Imaging revealed a 1.2 cm cystic pituitary mass consistent with a hemorrhagic Rathke’s cleft cyst. The patient underwent trans-sphenoidal resection of the pituitary cyst, and pathologic analysis revealed a squamous cell carcinoma lining a Rathke’s cleft cyst. Extensive imaging and otorhinolaryngologic evaluation revealed no primary source for metastasis. We feel this represents the first case of a patient with a pituitary lesion in which presentation and MRI imaging were consistent with Rathke’s cleft cyst, yet histology revealed squamous cell carcinoma in situ.

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Fulminating parapontine epidermoid carcinoma in a four-year-old boy

Cited by 37 publications

References 11 publications

Primary squamous cell carcinoma of the brain. A rare autopsy case

Primary squamous cell carcinoma of the brain. A rare autopsy case

Two Autopsy Cases Assessing the Association of Rare Tumors Adjacent to the Sella turcica with Cause of Death and a Review of the Literature

Non-metastatic squamous cell carcinoma within a Rathke’s cleft cyst

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