Fulminanter Typ-1b-Diabetes bei einer europäischen Schwangeren

Beuttler, Claudia

doi:10.1007/s11428-018-0385-0

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…FT1DM is characterized by a very short history of less than one week, marked symptoms with high blood glucose and relatively low HbA1c, absolute insulin deficiency, severe ketoacidosis, elevated pancreatic enzymes, and no evidence of autoimmunity. The manifestation is typical in pregnant women of Southeast Asian or Japanese origin; one case in a German woman has already been reported 47 . From case series, the stillbirth and neonatal death rate was about 66%.…”

Section: Introductionmentioning

confidence: 96%

COVID-19, Pregnancy, and Diabetes Mellitus

Kleinwechter,

Weber,

Liedtke

et al. 2023

Z Geburtshilfe Neonatol

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During the severe acute respiratory distress virus coronavirus type 2 (SARS-CoV-2) pandemic, many women were infected during their pregnancies. The SARS-CoV-2-induced coronavirus disease 19 (COVID-19) has an impact on maternal health and pregnancy outcomes; peripartum and perinatal morbidity and mortality are increased. Pregnancy is considered a risk factor for severe COVID-19 course. Additional risk factors during pregnancy are diabetes mellitus, gestational diabetes mellitus (GDM), and obesity. Systemic inflammation can lead to severe metabolic dysregulation with ketoacidosis. The endocrine pancreas is a target organ for SARS-CoV-2 and the fetal risk depends on inflammation of the placenta. Up to now there is no evidence that SARS-CoV-2 infection during pregnancy leads to permanent diabetes in mothers or their offspring via triggering autoimmunity or beta cell destruction. The frequently observed increased prevalence of GDM compared to the years before the pandemic is most likely due to changed lifestyle during lockdown. Furthermore, severe COVID-19 may be associated with the development of GDM due to worsening of glucose tolerance. Vaccination with a mRNA vaccine is safe and highly effective to prevent infection and to reduce hospitalization. Registries support offering evidence-based recommendations on vaccination for pregnant women. Even with the current omicron virus variant, there are increased risks for symptomatic and unvaccinated pregnant women.

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Section: Introductionmentioning

confidence: 96%