Fulminant sepsis caused by<i>Bacillus cereus</i>in patients with hematologic malignancies: analysis of its prognosis and risk factors

Inoue, Daichi; Nagai, Yuya; Mori, Minako; Nagano, Seiji; Takiuchi, Yoko; Arima, Hiroshi; Kimura, Takaharu; Shimoji, Sonoko; Togami, Katsuhiro; Tabata, Sumie; Yanagita, Soshi; Matsushita, Akiko; Nagai, Kenichi; Imai, Yukihiro; Takegawa, Hiroshi; Takahashi, Takayuki

doi:10.3109/10428191003713976

Cited by 36 publications

(43 citation statements)

References 33 publications

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“…This pathogen is a common cause of food poisoning (1,2) and may cause septicemia, surgical wound infection, pneumonia or meningitis in immunocompromised patients (3). Akiyama et al reported the case of a patient with ported 12 cases and analyzed a total of 58 previously reported cases of B. cereus septicemia in patients with hematologic malignancies (5). Their analysis indicated that acute leukemia, a neutrophil count of near 0/μL or the presence of central nervous system (CNS) symptoms during febrile episodes are associated with fatal prognoses.…”

Section: Introductionmentioning

confidence: 99%

A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

et al. 2012

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Objective Bacillus cereus (B. cereus) septicemia is a cause of life-threatening infection in patients with hematologic diseases. However, preventing a fatal prognosis in patients with B. cereus infection has not yet been achieved due to insufficient clinical investigations. To discover more optimal treatment strategies, we analyzed B. cereus septicemia in patients with hematologic diseases. Methods At our institution, we observed 13 cases of B. cereus septicemia in 12 patients with hematologic diseases between January 2001 and September 2010. The susceptibility of B. cereus strains to antibiotics was also analyzed. Results Of 12 patients, four died of B. cereus septicemia. In this study, the delayed administration of appropriate antibiotics (starting >24 hours after presentation), the presence of liver dysfunction and evidence of central nervous system (CNS) involvement tended to result in a fatal prognosis. All of the bacterial strains were found to be susceptible to vancomycin and quinolones (such as ciprofloxacin and levofloxacin), whereas many strains were resistant to clindamycin (76.9%) and imipenem (30.8%). In seven of 10 patients, central venous (CV) catheter tips were removed and routinely cultured. Catheter tip cultures were positive for B. cereus in three of seven patients. Conclusion Although not specific to B. cereus bacteremia, patients who died of B. cereus tended to present with CNS symptoms and/or liver dysfunction. Our clinical data suggested that carbapenem and clindamycin are no longer appropriate choices for treating B. cereus. In addition, B. cereus septicemia was found to frequently originate from CV catheters. Constant attention must be paid to update assessments of antibiotic susceptibility and careful management must be applied to CV catheters in patients with hematologic diseases.

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Section: Introductionmentioning

confidence: 99%

A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

et al. 2012

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“…However, outbreaks of catheter-related bloodstream infection (CRBSI) have been sporadically reported in association with a specific hospital environment or linens (9)(10)(11)(12)(13)(14)(15)(16)(17). Multiple fatal cases with serious B. cereus CRBSI were recently reported (3,6,(13)(14)(15)17).…”

Section: Discussionmentioning

confidence: 99%

“…A dual-chamber bag system for PPN solutions has been developed and distributed throughout Japan (26). The timing of the product development indicates that there may be an association with B. cereus BSI published in case reports (9,10,(12)(13)(14)(15)17).…”

Section: Discussionmentioning

confidence: 99%

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Use of Peripheral Parenteral Nutrition Solutions as a Risk Factor for <i>Bacillus cereus</i> Peripheral Venous Catheter-Associated Bloodstream Infection at a Japanese Tertiary Care Hospital: a Case-Control Study

Sakihama

Tokuda

2016

Jpn J Infect Dis

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SUMMARY:The risk factors are unclear for peripheral venous catheter-associated bloodstream infections (PVCBSIs) caused by Bacillus cereus. We aimed to examine for these risk factors in patients with B. cereus PVCBSI by conducting a 2-year case-control study in a large teaching hospital. We analyzed all adult cases of B. cereus PVCBSI (37 patients) and 180 controls who were randomly selected from among patients who had a PVC in place for at least 2 days. Multivariate analysis using a conditional logistic regression model indicated that independent risk factors were use of a peripheral parenteral nutrition (PPN) solution with an adjusted odds ratio (OR) of 88.7 (95z confidence interval [CI], 17.4-451.9), and steroid therapy (adjusted OR, 5.7 [95z CI,). In conclusion, use of PPN solutions or steroids was an independent risk factor for B. cereus PVCBSI. Appropriate use of PPN solutions may help prevent B. cereus PVCBSI. Prospective studies are needed to confirm these results.

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“…Of these various infections, B. cereus bloodstream infection (BSI) seems to be the most severe condition. However, clinical patient reviews for all inpatients have not been performed, except for immunocompromised patients [5,7].…”

Section: Introductionmentioning

confidence: 99%

Erratum to: Seasonal trend and clinical presentation of Bacillus cereus bloodstream infection: association with summer and indwelling catheter

Kato

Matsumura

Yamamoto

et al. 2016

Eur J Clin Microbiol Infect Dis

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Bacillus cereus, an opportunistic pathogen, can cause fatal infection. However, B. cereus bloodstream infections (BSIs) have not been well characterised. From 2008 to 2013, B. cereus isolates from all of the specimens and patients with B. cereus BSIs were identified. Environmental samples were collected to detect B. cereus contamination. We also characterised the clinical presentation of B. cereus BSI through analyses of risk factors for BSI and mortality. A total of 143 clinical B. cereus isolates was detected. Fifty-one patients with nosocomial infections were diagnosed as B. cereus BSI, and 37 had contaminated blood cultures. The number of B. cereus isolates and BSI patients was significantly greater from June to September than from January to April (3.4 vs. 1.0 per month and 1.4 vs. 0.2, respectively). All BSIs were nosocomial and related to central or peripheral vascular catheter. Urinary catheter [odds ratio (OR) 6.93, 95 % confidence interval (CI) 2.40-20.0] was the independent risk factor associated with BSI patients when compared to patients regarded as contaminated. In-hospital mortality among BSI patients was 20 % and was associated with urinary catheter (OR 12.3, p = 0.045) and higher Charlson index (OR 1.99,). The number of B. cereus isolates and BSI increased during summer. Inpatients with indwelling vascular or urinary catheters should be carefully monitored for potential B. cereus BSIs.

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Fulminant sepsis caused byBacillus cereusin patients with hematologic malignancies: analysis of its prognosis and risk factors

Cited by 36 publications

References 33 publications

A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

Use of Peripheral Parenteral Nutrition Solutions as a Risk Factor for <i>Bacillus cereus</i> Peripheral Venous Catheter-Associated Bloodstream Infection at a Japanese Tertiary Care Hospital: a Case-Control Study

Erratum to: Seasonal trend and clinical presentation of Bacillus cereus bloodstream infection: association with summer and indwelling catheter

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