Fulminant myocarditis in an adult with 2009 pandemic influenza A (H1N1 influenza) infection

Liao, Ying‐Chieh; Hsieh, Yu‐Cheng; Chang, Wei-Chun; Huang, Jin‐Long; Ting, Chih‐Tai; Wu, Tsu‐Juey

doi:10.1016/j.jcma.2011.01.028

Cited by 14 publications

(7 citation statements)

References 13 publications

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“…Komai et al reports unsuccessful use of mechanical circulatory support in FM [10]. However, some recent reports comment about successful outcome in FM following H1N1 infection with the use of mechanical circulatory support in the form of ECMO [11,12]. In the present case, we supported the failing heart in FM due to H1N1 Influenza infection with VA ECMO for 10 days leading to complete recovery.…”

Section: Discussionsupporting

confidence: 60%

Successful Treatment of Novel H1N1 Influenza related Fulminant Myocarditis with Extracorporeal Life Support

Mohite

Popov

Bartsch

et al. 2011

J Cardiothorac Surg

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The prevalence of myocardial involvement in influenza infection ranges from 0% to 12%. The 2009 pH1N1 influenza virus, formerly known as swine flu, first appeared in Mexico and the United States of America in March and April 2009 and has swept the globe with unprecedented speed. We report a case of fulminant myocarditis associated with this virus treated successfully using extra-corporal membrane oxygenator.

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Section: Discussionsupporting

confidence: 60%

Successful Treatment of Novel H1N1 Influenza related Fulminant Myocarditis with Extracorporeal Life Support

Mohite

Popov

Bartsch

et al. 2011

J Cardiothorac Surg

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“…There have been approximately 44 cases of influenza‐associated myocarditis in adult patients described in case reports and case series (Table ) . Among those reported, 52% (23/44) occurred in men and 68% (30/44) occurred in patients under 40 years of age.…”

Section: Resultsmentioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

323

308

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Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra‐pulmonary complications of influenza infection, using organ‐specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra‐pulmonary complications is critical to determining the true burden of influenza infection and initiating organ‐specific supportive care.

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“…Extrapulmonary complications of influenza virus infection have been previously reported. Around 50% of patients without previous cardiac history have abnormal electrocardiogram findings [57] and a link has been recently reported between influenza infection and acute myocardial infarction [58] and fulminant myocarditis in children [59] and adults [60].…”

Section: Discussionmentioning

confidence: 97%

Characterization In Vitro and In Vivo of a Pandemic H1N1 Influenza Virus from a Fatal Case

et al. 2013

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Pandemic 2009 H1N1 (pH1N1) influenza viruses caused mild symptoms in most infected patients. However, a greater rate of severe disease was observed in healthy young adults and children without co-morbid conditions. Here we tested whether influenza strains displaying differential virulence could be present among circulating pH1N1 viruses. The biological properties and the genotype of viruses isolated from a patient showing mild disease (M) or from a fatal case (F), both without known co-morbid conditions were compared in vitro and in vivo. The F virus presented faster growth kinetics and stronger induction of cytokines than M virus in human alveolar lung epithelial cells. In the murine model in vivo, the F virus showed a stronger morbidity and mortality than M virus. Remarkably, a higher proportion of mice presenting infectious virus in the hearts, was found in F virus-infected animals. Altogether, the data indicate that strains of pH1N1 virus with enhanced pathogenicity circulated during the 2009 pandemic. In addition, examination of chemokine receptor 5 (CCR5) genotype, recently reported as involved in severe influenza virus disease, revealed that the F virus-infected patient was homozygous for the deleted form of CCR5 receptor (CCR5Δ32).

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Fulminant myocarditis in an adult with 2009 pandemic influenza A (H1N1 influenza) infection

Cited by 14 publications

References 13 publications

Successful Treatment of Novel H1N1 Influenza related Fulminant Myocarditis with Extracorporeal Life Support

Successful Treatment of Novel H1N1 Influenza related Fulminant Myocarditis with Extracorporeal Life Support

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Characterization In Vitro and In Vivo of a Pandemic H1N1 Influenza Virus from a Fatal Case

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