Fulminant hepatic failure secondary to acetaminophen poisoning: A systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation

Bailey, Benoît; Amre, Devendra; Gaudreault, Pierre

doi:10.1097/00003246-200301000-00048

Cited by 165 publications

(100 citation statements)

References 17 publications

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“…The KCC demonstrate high specificity, but have been criticised for their low sensitivity and negative predictive value for a poor outcome 12,13 . Nevertheless these easy-to-use criteria have consistently outperformed novel scoring systems and remain the benchmark for prognostication in ALF.…”

Section: Introductionmentioning

confidence: 99%

Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

McPhail

Farne

Senvar

et al. 2016

Clinical Gastroenterology and Hepatology

105

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Section: Introductionmentioning

confidence: 99%

Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

McPhail

Farne

Senvar

et al. 2016

Clinical Gastroenterology and Hepatology

105

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“…Another meta-analysis performed to evaluate King's College criterion among patients with ALF, secondary to paracetamol, revealed sensitivity of 69% and specificity of 92%, but Q was 0.61 18 . To overcome these limitations, other alternative prognostic systems might be used 6 .…”

Section: Discussionmentioning

confidence: 99%

Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine

et al. 2016

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PURPOSE:To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy´s criteria evaluation. METHODS:Sixty-one Wistar female rats were distributed into three groups: group 1 (11 rats received 1.4 g/kg of d-galactosamine intraperitoneally and were observed until they died); group 2 (44 rats received a dose of 1.4 g/kg of d-galactosamine and blood and histological samples were collected for analysis at 12 , 24, 48 , 72 and 120 hours after the injection); and the control group as well (6 rats). RESULTS:Twelve hours after applying d-galactosamine, AST/ALT, bilirubin, factor V, PT and INR were already altered. The peak was reached at 48 hours. INR > 6.5 was found 12 hours after the injection and factor V < 30% after 24 hours. All the laboratory variables presented statistical differences, except urea (p = 0.758). There were statistical differences among all the histological variables analyzed. CONCLUSION:King's College and Clichy´s criteria were fulfilled 12 hours after the d-galactosamine injection and this time may represent the best time to intervene in this acute liver failure animal model.

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“…Recently, the Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ) score was described for determining prognosis in the setting of FHF. The APACHE Ⅱ used a combination of both clinical and laboratory parameters and its sensitivity was comparable to that of the King's College Criteria [39] . A recent study in 120 consecutive patients with FHF investigated the prognostic efficacies of King's College criteria, Clichy's criteria, the Model for End-Stage Liver Disease (MELD), and the Pediatric End-Stage Liver Disease (PELD).…”

Section: Discussionmentioning

confidence: 99%

Point-of-care continuous¹³C-methacetin breath test improves decision making in acute liver disease: Results of a pilot clinical trial

Lalazar¹,

Adar²,

Ilan³

2009

WJG

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AIM:To assess the role of the 13 C-methacetin breath test (MBT) in patients with acute liver disease. METHODS:Fifteen patients with severe acute liver disease from diverse etiologies were followed-up with 13 C-MBT during the acute phase of their illnesses (range 3-116 d after treatment). Patients fasted for 8 h and ingested 75 mg of methacetin prior to the MBT. We compared results from standard clinical assessment, serum liver enzymes, synthetic function, and breath test scores. RESULTS:Thirteen patients recovered and two patients died. In patients that recovered, MBT parameters improved in parallel with improvements in lab results. Evidence of consistent improvement began on day 3 for MBT parameters and between days 7 and 9 for blood tests. Later convergence to normality occurred at an average of 9 d for MBT parameters and from 13 to 28 d for blood tests. In both patients that died, MBT parameters remained low despite fluctuating laboratory values. CONCLUSION:The 13 C-MBT provides a rapid, noninvasive assessment of liver function in acute severe liver disease of diverse etiologies. The results of this pilot clinical trial suggest that the MBT may offer greater sensitivity than standard clinical tests for managing patients with severe acute liver disease.

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Fulminant hepatic failure secondary to acetaminophen poisoning: A systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation

Abstract: Presently, available criteria are not very sensitive and may miss patients requiring transplantation. Future studies should further evaluate the efficacy of the APACHE II criteria.

Cited by 165 publications

References 17 publications

Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine

Point-of-care continuous¹³C-methacetin breath test improves decision making in acute liver disease: Results of a pilot clinical trial

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Fulminant hepatic failure secondary to acetaminophen poisoning: A systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation

Abstract: Presently, available criteria are not very sensitive and may miss patients requiring transplantation. Future studies should further evaluate the efficacy of the APACHE II criteria.

Cited by 165 publications

References 17 publications

Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine

Point-of-care continuous13C-methacetin breath test improves decision making in acute liver disease: Results of a pilot clinical trial

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Point-of-care continuous¹³C-methacetin breath test improves decision making in acute liver disease: Results of a pilot clinical trial