Fulminant hepatic failure (FHF) due to acute hepatitis C

Younis, Bilal Bin; Arshad, Rozina; Khurhsid, Saima; Masood, Junaid; Nazir, Farhan; Tahira, Maham

doi:10.12669/pjms.314.7618

Cited by 11 publications

(8 citation statements)

References 6 publications

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“…9 Hepatitis C was previously considered a rare cause of fulminant hepatic failure but now observed as an important cause in many studies. 16,17 We did not find any case of acute fatty liver of pregnancy which is also an important cause of FHF in pregnancy. Sahai reported acute fatty liver of pregnancy in 3.57% cases.…”

Section: Discussionmentioning

confidence: 64%

Fulminant hepatic failure during pregnancy.

Nazish

Inayatullah

Zahra

2021

TPMJ

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Objective: To observe clinical characteristics, etiology and maternal outcome in fulminant hepatic failure during pregnancy. Study Design: Descriptive Case Series. Setting: Department of Medicine, Nishtar Hospital Multan. Period: January 2013 to December 2017. Material & Methods: Twenty nine consecutive patients with fulminant hepatic failure during pregnancy were included in the study. Results: Mean age of patients was 27.06±6.92 years. 65.51% patients were from urban areas. Mean duration of gestation was 24.80±6.03 weeks. Jaundice and altered consciousness were observed in 100% cases, pallor in 79.31%, hepatomegaly in 20.68%, flapping tremors in 10.34%, ascites in 10.34% and splenomegaly in 6.89% cases. Complications observed were cerebral edema in 44.82%, renal failure in 24.13%, bleeding in 20.68% and hypoglycemia in 3.44%. Most common cause was acute hepatitis E (75.86%) followed by hepatitis B (13.79%) and hepatitis A (3.44%). No cause was found in 6.89% cases. Overall maternal mortality was 37.93% and fetal mortality was 72.41%. In 17.24% cases pregnancy was terminated therapeutically, 44.82% cases had spontaneous expulsion and in 37.93 % cases pregnancy continued. Maternal mortality was highest (45.45%) in patients who remained pregnant as compared to 20% when pregnancy was terminated therapeutically. Conclusion: Jaundice and altered conscious level is the most common clinical presentation. Hepatitis E is the most common cause of FHF in pregnancy. Maternal mortality in FHF during pregnancy is very high.

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Section: Discussionmentioning

confidence: 64%

Fulminant hepatic failure during pregnancy.

Nazish

Inayatullah

Zahra

2021

TPMJ

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“…Infrequently, cases of fulminant hepatitis C have been recorded so far [12,13]. Pathobiology of viral hepatitis in the era before 1957 significantly differed from the present status.…”

Section: Hbv Infection Was Observed As Frequently As 80% In the Kyushumentioning

confidence: 94%

Detection of Hepatitis Virus B And C in Archival Autopsy Specimens of Liver Cirrhosis

Tsutsumi¹,

Shiogama

Teramoto

et al. 2019

BJSTR

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Archival pathology specimens long-conserved in pathology divisions are of historical value [1][2][3][4]. In some institutions, formalin-fixed tissues are preserved for a long period of time. In the present article, we tried to detect hepatitis B and C viruses in archival autopsy specimens, in order to know the times when hepatitis viruses existed in Japan, based on the epidemiological and historical point of view. The archival specimens were provided from Kyushu University and Niigata University. Fixed human autopsy specimens are open to the public in Kyushu University Museum, Fukuoka, and 10 liver tissues of advanced liver cirrhosis autopsied in the period from 1907 to 1930 were sampled after a long fixation period. In addition, a total of 22 paraffin blocks of liver lesions (chronic active

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“…Most cases of ALF associated with viral hepatitis worldwide are reported after infection with hepatitis A virus (HAV) and hepatitis E virus (HEV) [ 21 ]. Hepatitis C virus (HCV) infection is described as the most common cause of non-A and non-B (NANB) hepatitis and can cause fulminant liver failure with a mortality rate of up to 92% [ 23 ]. Acute-chronic liver failure (ACLF) is a relatively new clinical entity that refers to the acute worsening of pre-existing chronic liver disease.…”

Section: Lagovirus Europaeus Is a Study Model For Alfmentioning

confidence: 99%

The Interplay between Autophagy and Virus Pathogenesis—The Significance of Autophagy in Viral Hepatitis and Viral Hemorrhagic Fevers

Bębnowska¹,

Niedźwiedzka-Rystwej²

2022

Cells

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Autophagy is a process focused on maintaining the homeostasis of organisms; nevertheless, the role of this process has also been widely documented in viral infections. Thus, xenophagy is a selective form of autophagy targeting viruses. However, the relation between autophagy and viruses is ambiguous—this process may be used as a strategy to fight with a virus, but is also in favor of the virus’s replication. In this paper, we have gathered data on autophagy in viral hepatitis and viral hemorrhagic fevers and the relations impacting its viral pathogenesis. Thus, autophagy is a potential therapeutic target, but research is needed to fully understand the mechanisms by which the virus interacts with the autophagic machinery. These studies must be performed in specific research models other than the natural host for many reasons. In this paper, we also indicate Lagovirus europaeus virus as a potentially good research model for acute liver failure and viral hemorrhagic disease.

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Fulminant hepatic failure (FHF) due to acute hepatitis C

Cited by 11 publications

References 6 publications

Fulminant hepatic failure during pregnancy.

Fulminant hepatic failure during pregnancy.

Detection of Hepatitis Virus B And C in Archival Autopsy Specimens of Liver Cirrhosis

The Interplay between Autophagy and Virus Pathogenesis—The Significance of Autophagy in Viral Hepatitis and Viral Hemorrhagic Fevers

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