Fulminant Gastrointestinal Langerhans Cell Histiocytosis Induced by Severe Acute Respiratory Syndrome Coronavirus 2

Abstract

Langerhans cell histiocytosis (LCH) is a rare disease that commonly affects the skin and bones and is found mostly in children. Gastrointestinal (GI) involvement in adults is rare and is diagnosed during a routine colonoscopy from the biopsy of polypoid lesions. The pathophysiology of LCH is unclear. We describe an adult patient with LCH in remission who presented with extensive GI involvement after severe acute respiratory syndrome coronavirus 2 infection. This case report identifies severe acute respiratory syndrome coronavirus 2 as a trigger for the worsening of LCH and adds more data to the literature, given this is the first case with fulminant GI involvement.