Fulminant form of acute disseminated encephalomyelitis: successful treatment with hypothermia

Takata, Tsuyoshi; Hirakawa, M; Sakurai, Masaki; Kanazawa, Ichiro

doi:10.1016/s0022-510x(99)00089-1

Cited by 47 publications

(31 citation statements)

References 12 publications

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“…Solitary or multiple foci of demyelination in cerebrum, cerebellum, brain stem and spinal cord have been described. Fulminant forms, as in our case, have occasionally been described and are often associated with a poor prognosis [3,5,6].…”

Section: Discussionsupporting

confidence: 56%

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Successful Recovery of a Fulminant Form of Acute Disseminated Encephalomyelitis (ADEM) with Intravenous Steroids

Kuhn

Bewermeyer²

2005

Klinische Neuroradiologie

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Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system mostly associated with a preceding infection or vaccination. It is characterized by multifocal white matter lesions on neuroimaging. A patient is described who developed a fulminant form of ADEM after a bacterial skin infection. Despite poor prognostic factors and extensive white matter lesions, the patient recovered dramatically under high-dose administration of steroids.

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Section: Discussionsupporting

confidence: 56%

“…If that fails, intravenous immunoglobulins, plasmapheresis or cytostatic drugs are alternatives for treatment [1][2][3]. In one case hypothermia has been used with success [6].…”

Section: Discussionmentioning

confidence: 99%

Successful Recovery of a Fulminant Form of Acute Disseminated Encephalomyelitis (ADEM) with Intravenous Steroids

Kuhn

Bewermeyer²

2005

Klinische Neuroradiologie

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“…Although treatment with immunosuppressives was commenced, the severity of her condition indicated that only surgical intervention was likely to be life saving. In other reported cases where significant mass effect has been described, patients have been treated with steroids [3], plasma exchange [3], and hypothermia [4]. Decompressive craniectomy has been well described in the management of Fig.…”

Section: Resultsmentioning

confidence: 99%

Decompressive Craniectomy for Acute Disseminated Encephalomyelitis

et al. 2010

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“…24 In cases that fail to respond to medical management, hemicraniectomy should be offered on the basis of the overall favorable prognosis of these conditions and positive response to therapy. [22][23][24][67][68][69] Summary Fulminant demyelinating diseases demonstrate significant overlap in presenting clinical and radiographic features. Discriminating the various subtypes has important prognostic and treatment implications.…”

Section: Supportive Carementioning

confidence: 99%

Fulminant Demyelinating Diseases

Rahmlow

Kantarci

2013

The Neurohospitalist

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Fulminant demyelinating disease is a heading that covers acute disseminated encephalomyelitis and its variant acute hemorrhagic leukoencephalitis (Hurst disease), severe relapses of multiple sclerosis (MS), variants of MS (tumefactive MS, Marburg variant, Balo concentric sclerosis, myelinoclastic diffuse sclerosis), and neuromyelitis optica-spectrum disorders associated with aquaporin autoimmunity. These categories of inflammatory demyelinating disease often prompt hospital admission and many necessitate intensive care monitoring due to the aggressive nature of the illness and associated neurologic morbidity. In this review, we highlight the discriminating clinical, radiographic, and pathologic features of these disorders. Acute management is often accomplished with use of high-dose intravenous steroids and plasma exchange. Aggressive disease may respond to immunosuppression. Prognosis for recovery varies among the disorders but most patients improve. Factors influencing outcome are also discussed.

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Fulminant form of acute disseminated encephalomyelitis: successful treatment with hypothermia

Cited by 47 publications

References 12 publications

Successful Recovery of a Fulminant Form of Acute Disseminated Encephalomyelitis (ADEM) with Intravenous Steroids

Successful Recovery of a Fulminant Form of Acute Disseminated Encephalomyelitis (ADEM) with Intravenous Steroids

Decompressive Craniectomy for Acute Disseminated Encephalomyelitis

Fulminant Demyelinating Diseases

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