“…Calciphylaxis is associated with a high mortality rate, especially when the trunk is involved, as opposed to the expectation of a better prognosis when the involvement is limited to the extremities. 46 The mechanisms potentially involved are many, 47 and the risk factors already described are: female gender, deficit of antithrombin III and/or protein C or S, 48 use of corticosteroids, 49 immunosuppressors, 50 oral anticoagulant, 51 estrogens, 52 intravenous iron overload, 53 smoking, diabetes mellitus, heart failure, morbid obesity, malnutrition, 54 dyslipidemia, losing weight, local traumas, and severe clinical settings such as sepsis, endocarditis, hepatic cirrhosis, and processes with a subjacent immunologic basis. 55 The laboratory evaluation generally demonstrates an increase in PTH.…”