Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

Choi, Yeon Sik; Yin, Rose T.; Pfenniger, Anna; Koo, Jahyun; Avila, Raudel; Lee, Kyongjune B.; Chen, Sheena W.; Lee, Geumbee; Liu, Gang; Qiao, Yun; Murillo-Berlioz, Alejandro; Kiss, Alexi; Han, Shuling; Lee, Seung Min; Li, Chenhang; Xie, Zhaoqian; Chen, Yu Yu; Burrell, Amy; Geist, Beth; Jeong, Hyoyoung; Kim, Joohee; Yoon, Hong‐Joon; Banks, Anthony; Kang, Seung Kyun; Zhang, Zheng Jenny; Haney, Chad R.; Sahakian, Alan V.; Johnson, David A.; Efimova, Tatiana; Huang, Yonggang; Trachiotis, Gregory D.; Knight, Bradley P.; Arora, Rishi; Efimov, Igor R.; Rogers, John A.

doi:10.1038/s41587-021-00948-x

Cited by 212 publications

(195 citation statements)

References 46 publications

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“…Compared with parallel processing speed of our neural system, there is still a huge gap within wearable electronic devices toward realizing the “Internet of Things.” In addition, flexible analog and digital circuits for wireless data transmission also need to be explored for efficient sending and receiving. 238…”

Section: Discussionmentioning

confidence: 99%

Challenges and emerging opportunities in transistor-based ultrathin electronics: design and fabrication for healthcare applications

Shao

et al. 2022

J. Mater. Chem. C

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Section: Discussionmentioning

confidence: 99%

Challenges and emerging opportunities in transistor-based ultrathin electronics: design and fabrication for healthcare applications

Shao

et al. 2022

J. Mater. Chem. C

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“…[378] Transient silicon nanomembrane devices have been used for highres olution spatial mapping of cortical activity, monitoring inter cranial pressure in rats, and wireless bioresorbable cardiac pacemakers. [379][380][381] Biodegradable elastomers have also garnered interest as substrate materials for bioresorbable electronics. Poly(1,8octanediolcocitrate) (POC) is one such biodegradable elastomer initially developed for tissue engineering applications that have been explored as a substrate for bioelectronics.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

et al. 2022

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Designing bioelectronic devices that seamlessly integrate with the human body is a technological pursuit of great importance. Bioelectronic medical devices that reliably and chronically interface with the body can advance neuroscience, health monitoring, diagnostics, and therapeutics. Recent major efforts focus on investigating strategies to fabricate flexible, stretchable, and soft electronic devices, and advances in materials chemistry have emerged as fundamental to the creation of the next generation of bioelectronics. This review summarizes contemporary advances and forthcoming technical challenges related to three principal components of bioelectronic devices: i) substrates and structural materials, ii) barrier and encapsulation materials, and iii) conductive materials. Through notable illustrations from the literature, integration and device fabrication strategies and associated challenges for each material class are highlighted.

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“…[192,249] An electrically controlled drug delivery system has successfully achieved and combined with real-time biometric analysis to provide precise diabetic prognosis and therapy (Figure 9b). [192] Therefore, the development of biodegradable and bioresorbable bioelectronics [311] for medical applications holds great promise to better human health.…”

Section: Thermo-responsive Gelling System For Localized Ocular Drug R...mentioning

confidence: 99%

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

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Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

Cited by 212 publications

References 46 publications

Challenges and emerging opportunities in transistor-based ultrathin electronics: design and fabrication for healthcare applications

Challenges and emerging opportunities in transistor-based ultrathin electronics: design and fabrication for healthcare applications

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

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