Fullerenol protects cornea from ultraviolet B exposure

Chen, Xia; Yang, Junling; Li, Minghui; Zhu, Shuang; Zhao, Maoru; Cao, Yang; Liu, Bo; Gao, Hui; Lu, Ao; Ge, Lingling; Mo, Lingyue; Gu, Zhennan; Xu, Haiwei

doi:10.1016/j.redox.2022.102360

Cited by 16 publications

(16 citation statements)

References 68 publications

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“…Identical to previous studies ( Wang et al, 2016 ) ( Zha et al, 2022 ), the diameter of our aqueous fullerenol ranged from 100 to 1,000 nm. Notably, fullerenol was also manufactured to be nanomaterial with diameter lower than 100 nm ( Chen et al, 2022 ). In terms of biological function, fullerenol show good biocompatibility and low side effects in numerous studies ( Yang et al, 2021 ) ( Yang et al, 2014b ) ( Zhu et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

“…It was found that fullerenol showed excellent curative or preventive effects on bleomycin-induced pulmonary fibrosis ( Zhou et al, 2018 ), intervertebral disk degeneration ( Yang et al, 2014a ), myocardial ischemia-reperfusion injury ( Ding and Li, 2020 ), osteoarthritis ( Pei et al, 2019 ). In the meantime, fullerenol has the ability to rescue HaCaT human skin keratinocytes and corneal epithelial cells from ultraviolet B (wavelength between 280 and 320 nm) ( Saitoh et al, 2011 ) ( Chen et al, 2022 ). Apart from these, fullerenol presents promising results of osteogenic differentiation induction to repair bone defect.…”

Section: Introductionmentioning

confidence: 99%

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Fullerenol inhibits tendinopathy by alleviating inflammation

Jiao

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Tendinopathy is a common disease in orthopaedics, seriously affecting tendon functions. However, the effects of non-surgical treatment on tendinopathy are not satisfactory and surgical treatments possibly impair the function of tendons. Biomaterial fullerenol has been proved to show good anti-inflammatory effects on various inflammatory diseases. For in vitro experiments, primary rat tendon cells (TCs) were treated by interleukin-1 beta (IL-1β) combined with aqueous fullerenol (5, 1, 0.3 μg/mL). Then inflammatory factors, tendon-related markers, migration and signaling pathways were detected. For in vivo experiments, rat tendinopathy model was constructed by local injection of collagenase into Achilles tendons of rats and fullerenol (0.5, 1 mg/mL) was locally injected 7 days after collagenase injection. Inflammatory factors and tendon-related markers were also investigated. Fullerenol with good water-solubility showed excellent biocompatibility with TCs. Fullerenol could increase expression of tendon-related factors (Collagen I and tenascin C) and decrease expression of inflammatory factors (matrix metalloproteinases-3, MMP-3, and MMP-13) and reactive oxygen species (ROS) level. Simultaneously, fullerenol slowed the migration of TCs and inhibited activation of Mitogen-activated protein kinase (MAPK) signaling pathway. Fullerenol also attenuated tendinopathy in vivo, including reduction of fiber disorders, decrease of inflammatory factors and increase of tendon markers. In summary, fullerenol is a promising biomaterial that can be used to treat tendinopathy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fullerenol inhibits tendinopathy by alleviating inflammation

Jiao

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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“…We speculate that this is due to the function of fullerenol itself. A previous study used RNA sequencing analysis to confirm that fullerenol itself can alleviate corneal oxidative injury by downregulation of oxidative stress-associated genes and upregulation of proliferation-related genes ( 19 ). However, the function of fullerenol in RPE cells needs further investigation in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Fullerenol (C60[OH]n), derived from fullerene C60, shows great antioxidative potential in pharmaceutics and medical treatment of oxidative stress-related diseases ( 18 ). The good water solubility of fullerenol makes it useful in pharmaceutics and medical treatment of oxidative stress-related diseases ( 19 , 20 ). It can remove free radicals such as superoxide anion radicals, hydroxyl radicals, lipid peroxyl radicals, and nitrous oxide radicals, making it effective in anti-aging, antioxidant stress, anti-inflammation, and anti-apoptosis ( 21 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress

Yao²,

Xu³

et al. 2022

Front. Med.

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Age-related macular degeneration (AMD) causes central vision impairment with increased incidence. In the pathogenesis of AMD, reactive oxygen species (ROS) are associated with RPE cell apoptosis. H2O2 is an oxidative toxicant and is used to establish the AMD in vitro model. However, the mechanisms of ROS in H2O2-induced AMD are still unclear. Fullerenol, a promising antioxidant of nanomaterials, protects RPE cells from ROS attack. In addition to working as a scavenger, little is known about the antioxidant mechanism of fullerenol in RPE cells. In this study, transcriptome sequencing was performed to examine the global changes in mRNA transcripts induced by H2O2 in human ARPE-19 cells. Moreover, we comprehensively investigated the protective effects of fullerenol against H2O2-induced oxidative injury by RNA sequencing. Gene Ontology enrichment analysis showed that those pathways related to the release of positive regulation of DNA-templated transcription and negative regulation of apoptotic process were affected. Finally, we found that 12 hub genes were related to the oxidative-protection function of fullerenol. In summary, H2O2 affected these hub genes and signaling pathways to regulate the senescence of RPE cells. Moreover, fullerenol is a potent nanomaterial that protects the RPE and would be a promising approach for AMD prevention.

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“…1) as an endogenous molecule exhibits the strongest inhibitory effects on UVB‐induced human corneal epithelial cell apoptosis while its immunosuppressive effect restricts clinical application (2). Broad‐spectrum UV shielding originating from intramolecular conjugated system is another desirable feature, which can improve long‐term UV‐photoprotection (14).…”

Section: Introductionmentioning

confidence: 99%

Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV‐B‐Induced Corneal Damage

Jiang

Qin

et al. 2022

Photochem & Photobiology

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UV-B-induced corneal damage remains a challenge in clinics, and it is needed to develop novel and effective medicines against UV-B induced photodamage. 3,4-Dihydropyrimidine-2 (1H)-thione derivatives have shown many interesting biological activities, including antibacterial, anti-inflammatory, antioxidant, etc. In order to find a promising anticorneal photodamage agent, we designed and synthesized two novel sulfonated dihydropyrimidinthione derivatives to evaluate cytoprotective effect against UV-B-mediated photodamage. With simple structure, compound 6 possessed good water solubility, photostability and biocompatibility. We demonstrated that 6 exhibited significant cytoprotective effects against UV-B-mediated photodamage and the cell viability was up to 93% at 0.2 mg mL À1 . The corneal cells were highly sensitive to UV-B radiation, resulting in the release of inflammatory mediators and DNA damage, which were significantly reversed by 6. Moreover, compound 6 reduced Bax and cleaved Caspase-3 expressions to suppress UV-B mediated the intrinsic apoptosis pathway. Our findings suggest that 6 is a promising UV-B resistant agent with potential to be a promising drug candidate for the treatment of corneal photodamage.

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Fullerenol protects cornea from ultraviolet B exposure

Cited by 16 publications

References 68 publications

Fullerenol inhibits tendinopathy by alleviating inflammation

Fullerenol inhibits tendinopathy by alleviating inflammation

The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress

Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV‐B‐Induced Corneal Damage

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