Fullerene derivatives with amino acids, peptides and proteins: From synthesis to biomedical application

Почкаева, Е. И.; Podolsky, Nikita E.; Zakusilo, Dmitry N.; Petrov, Andrey V.; Чарыков, Н. А.; Власов, Т. Д.; Penkova, Anastasia V.; Vasina, Lubov V.; Murin, I. V.; Sharoyko, Vladimir V.; Semenov, Konstantin N.

doi:10.1016/j.progsolidstchem.2019.100255

Cited by 64 publications

(39 citation statements)

References 122 publications

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“…The discovery of fullerenes in late 1985 is among the biggest breakthroughs in chemistry . The singular geometry and chemical and physical properties of these carbon allotropes make them suitable molecular building blocks for both bio‐medical chemistry and materials science . Among these molecular scaffolds, C 60 has been the most widely used chemical platform to synthesize novel compounds that display biological activity .…”

Section: Introductionmentioning

confidence: 99%

[60]Fullerene Hybrids Bearing “Steroid Wings”: A Joined Experimental and Theoretical Investigation

et al. 2020

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Novel [60]fullerene-steroid hybrids have been synthesized by Bingel-Hirsch cyclopropanation reaction between C 60 and steroid malonates, leading to conjugates in which a [60]fullerene unit is connected to one or two dehydroepiandrosterone moieties, an important naturally occurring steroid hormone. The obtained derivatives have been fully characterized by a whole set of instrumental techniques in order to determine their chemical structure. Moreover, their electrochemical properties, investigated by cyclic voltammetry, revealed the presence of three reversible reduction waves for both hybrids. Furthermore, Transmission Electron Microscopy studies allowed to [a

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Section: Introductionmentioning

confidence: 99%

[60]Fullerene Hybrids Bearing “Steroid Wings”: A Joined Experimental and Theoretical Investigation

et al. 2020

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“…Fullerenes and carbon nanodiamonds are some of the other commonly employed CNMs in several biomedical applications due to their unique physicochemical properties [ [193] , [194] , [195] , [196] ]. This section will discuss about the application of these CNMs in cardiovascular theranostics.…”

Section: Application Of Cnms In Cardiovascular Tissue Engineeringmentioning

confidence: 99%

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

Alagarsamy

Mathan

Yan

et al. 2021

Bioactive Materials

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to “damage-control” rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family of carbon allotropes (including graphenes, carbon nanotubes and fullerenes) have unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability and optical properties. These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics. This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes. The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials. The second section covers their application in drug delivery, biosensors, tissue engineering and immunomodulation with a focus on cardiovascular applications. The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside.

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“…The electronic, mechanical, and magnetic properties of carbon nanostructures (CNSs) have been extensively studied (Chand 2000, Zhu & Xu 2010, Kukovecz et al 2013, Ahn & Hong 2014, Lim et al 2015, Champi et al 2016, Karousis et al 2016, Acatay 2017, Liu et al 2018, Pochkaeva et al 2020.…”

Section: Carbon Nanostructured Materialsmentioning

confidence: 99%