Full wave model of image formation in optical coherence tomography applicable to general samples

Munro, Peter; Curatolo, Andrea; Sampson, David D.

doi:10.1364/oe.23.002541

Cited by 39 publications

(41 citation statements)

References 41 publications

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“…28 To date, there are three main approaches to take into account for multiple scattering in OCT: probabilistically, with Monte Carlo simulations; 53,54 and analytically, with the extended Huygens-Fresnel (EHF) model for OCT 45,55,56 or ab initio full-wave simulations based on Maxwell's equations. [57][58][59] We briefly discuss each below.…”

Section: Multiple Scatteringmentioning

confidence: 99%

“…A full-wave mathematical model of OCT image formation, based on Maxwell's equations, has been developed by Munro et al [57][58][59] Using this model, 2-D and 3-D OCT images can be simulated. Compared to the above-mentioned models, the Maxwell's equations-based model does not need to assume the first-order Born approximation or to consider an ensemble average of the scattering particles.…”

Section: Modeling Of the Oct Signal With Maxwell's Equationsmentioning

confidence: 99%

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Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

et al. 2020

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Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT attenuation coefficient and developing them toward clinical applications. Aim: Our review provides an overview of the main models and methods, their assumptions and applicability, together with a survey of preclinical and clinical demonstrations and their translation potential. Results: The use of the attenuation coefficient, particularly when presented in the form of parametric en face images, is shown to be applicable in various medical fields. Most studies show the promise of the OCT attenuation coefficient in differentiating between tissues of clinical interest but vary widely in approach. Conclusions: As a future step, a consensus on the model and method used for the determination of the attenuation coefficient is an important precursor to large-scale studies. With our review, we hope to provide a basis for discussion toward establishing this consensus.

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Section: Multiple Scatteringmentioning

confidence: 99%

Section: Modeling Of the Oct Signal With Maxwell's Equationsmentioning

confidence: 99%

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

et al. 2020

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“…Indeed, we have previously demonstrated how image formation for the system shown in Fig. 1 can be rigorously simulated for arbitrary scattering configurations using a single stage of computation, but within a two-dimensional approximation [3]. In particular, the lens and sample were assumed to extend uniformly in one of the transverse directions.…”

Section: Background To Algorithmmentioning

confidence: 99%

“…There is currently a growing interest in rigorous simulation of broadband, coherent optical imaging systems, particularly those aimed at resolution in the tens of microns, such as optical coherence tomography (OCT) [1][2][3]. This is being enabled by advancements in both algorithms and computer hardware which, in combination, make the simulation of image formation for practically significant tissue volumes feasible.…”

Section: Introductionmentioning

confidence: 99%

Exploiting data redundancy in computational optical imaging

Munro¹

2015

Opt. Express

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We present an algorithm which exploits data redundancy to make computational, coherent, optical imaging more computationally efficient. This algorithm specifically addresses the computation of how light scattered by a sample is collected and coherently detected. It is of greatest benefit in the simulation of broadband optical systems employing coherent detection, such as optical coherence tomography. Although also amenable to time-harmonic data, the algorithm is designed to be embedded within time-domain electromagnetic scattering simulators such as the psuedo-spectral and finite-difference time domain methods. We derive the algorithm in detail as well as criteria which ensure accurate execution of the algorithm. We present simulations that verify the developed algorithm and demonstrate its utility. We expect this algorithm to be important to future developments in computational imaging.

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“…The formalism has also been applied to focusing through stratified media (see, for example [6][7][8] ). This is an important extension to focusing theory due to the large number of applications where this is relevant, such as image formation in high numerical aperture confocal microscopes, 9 optical coherence tomography (OCT), 10 and photoacoustic imaging, 11 to name just a few.…”

Section: Introductionmentioning

confidence: 99%

Tool for simulating the focusing of arbitrary vector beams in free-space and stratified media

Munro

2018

J. Biomed. Opt.

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Vectorial models of focused beams are important to a variety of fields including microscopy, lithography, optical physics, and biomedical imaging. This has led to many models being developed, which calculate how beams of various profiles are focused both in free space and in the presence of stratified media. The majority of existing models begin with a vectorial diffraction formula, often referred to as the Debye-Wolf integral, which must be evaluated partially analytically and partially numerically. The complexity of both the analytic and numerical evaluations increases significantly when exotic beams are modeled, or, a stratified medium is located in the focal region. However, modern-day computing resources permit this integral to be evaluated entirely numerically for most applications. This allows for the development of a vectorial model of focusing in which the focusing itself, interaction with a stratified medium, and incident beam specification are independent, allowing for a model of unprecedented flexibility. We outline the theory upon which this model is developed and show examples of how the model can be used in applications including optical coherence tomography, high numerical aperture microscopy, and the properties of cylindrical vector beams. We have made the computer code freely available.

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Full wave model of image formation in optical coherence tomography applicable to general samples

Cited by 39 publications

References 41 publications

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

Exploiting data redundancy in computational optical imaging

Tool for simulating the focusing of arbitrary vector beams in free-space and stratified media

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