Full thickness macular hole after intravitreal brolucizumab injection in neovascular age-related macular degeneration

Abstract

Purpose To describe a case of full thickness macular hole after intravitreal brolucizumab injection in neovascular age-related macular degeneration, which has not been reported to date. Case description A 65-year-old male patient received brolucizumab intravitreal injection therapy for neovascular macular degeneration of the right eye. He received multiple intravitreal anti-VEGF injections on a pro re nata regimen and developed a full thickness macular hole. Outcome Surgical treatment was performed with pars plana vitrectomy of the right eye. Full thickness macular hole was successfully treated. Conclusion Although a full thickness macular hole following intravitreal brolucizumab injection is an uncommon complication, it requires caution.