Full-term pregnancy in breast cancer survivor with fertility preservation: A case report and review of literature

Garrido-Marín, Marta; Argacha, Pedro Maria; Fernández, Luís; Molfino, Florencia; Martínez‐Soler, Fina; Tortosa, Avelina; Gimenez‐Bonafé, Pepita

doi:10.12998/wjcc.v7.i1.58

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Although after fertility preservation and oncology treatments the first option of most patients is to naturally conceive [ 25 ], the female age and the low AMH level (0.15 μg/l) justified the use of assisted reproductive techniques (ART). This case resulted in a live birth without complications, as similarly reported by Garrido-Marrín and colleagues [ 4 ]. In both cases, the patients returned to the clinic post-chemotherapy and with over 40 years of age [ 4 ].…”

Section: Discussionsupporting

confidence: 80%

“…This case resulted in a live birth without complications, as similarly reported by Garrido-Marrín and colleagues [ 4 ]. In both cases, the patients returned to the clinic post-chemotherapy and with over 40 years of age [ 4 ]. Healthy live births were also achieved in a combination of IVM and oocyte cryopreservation, despite lower efficiency when compared with using fresh IVM oocytes [ 3 , 12 ].…”

Section: Discussionsupporting

confidence: 80%

“…Although the incidence of cancer is higher in patients over 50 years old, there is a growing number of diagnoses in younger patients. In particular, breast cancer accounts for one-third of cancer diagnosis in reproductive-aged women [ 4 , 5 ]. As a result, there is an increasing number of these women seeking to preserve their reproductive potential.…”

Section: Introductionmentioning

confidence: 99%

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Oncofertility case report: live birth 10 years after oocyte in vitro maturation and zygote cryopreservation

Rodrigues

Marques²,

Pimentel³

et al. 2020

J Assist Reprod Genet

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Purpose This study aims to report a case of urgent fertility preservation in an oncological patient with collection of immature oocytes in the absence of ovarian stimulation that, through in vitro maturation (IVM), followed by ICSI and cryopreservation of zygotes resulted, 10 years later, in the live birth of a healthy baby. Methods In September 2008, our clinic performed IVM in a 32-year-old woman diagnosed with a ductal invasive carcinoma with positive estradiol receptors, negative progesterone receptors and positive human epidermal growth factor receptor 2. The retrieval of immature oocytes was performed in the absence of ovarian stimulation after a simple mastectomy and prior to any chemotherapy treatment. The compact cumulus-oocyte complexes (COCs) collected were placed in Lag medium for 2 h, followed by incubation in IVM medium, supplemented with heat inactivated patient serum, recombinant FSH, and recombinant LH. After 30 h in culture, cumulus cells were removed, the metaphase II oocytes were microinjected, and the zygotes obtained were cryopreserved. In 2017, the zygotes were thawed and cultured until day 3. One embryo was transferred and the other cryopreserved. Results Four compact COCs were collected and subjected to IVM. Two oocytes reached metaphase II and were microinjected. Two zygotes were obtained and were cryopreserved at the two pronuclear stage. Approximately 9 years later, the two zygotes were thawed and cultured until day 3. An embryo with 10 cells was transferred and implanted, resulting in the birth of a healthy baby. Conclusions In cases where urgency to start adjuvant therapy requires immediate oocyte collection, IVM may be the only option to obtain fully competent mature oocytes allowing for effective preservation of the reproductive potential.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oncofertility case report: live birth 10 years after oocyte in vitro maturation and zygote cryopreservation

Rodrigues

Marques²,

Pimentel³

et al. 2020

J Assist Reprod Genet

View full text Add to dashboard Cite

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“…Fertility preservation may occur with embryo or oocyte cryopreservation to protect future fertility. Ovarian stimulation may be carried out before beginning chemotherapy but may result in a delay in treatment and increased estradiol levels ( Tomasi-Cont, Lambertini, Hulsbosch, Peccatori, & Amant, 2014 ; Garrido-Marín, 2019 ; Yu et al, 2017 ). General chemotherapy risks include preterm delivery, low birth weight, transient tachypnea of newborn, and transient neonatal leukopenia.…”

Section: Chemotherapy Treatmentmentioning

confidence: 99%

Treatment of Pregnancy-Associated Breast Cancer

Labriola¹

2019

JADPRO

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KS is a 33-year-old Caucasian married woman who works full time as an accountant and has one daughter who is 2 years old. She enjoys reading and exercising in her spare time. She initially presented in July 2015 at the age of 31 years with a 1-cm breast mass in the left inner breast, which prompted a mammogram to be obtained. The mammogram revealed diffuse and occasionally grouped left breast calcifications. Additionally, there was focal edema at the site of the mass. A follow-up mammogram was recommended to document stability in 6 months, which demonstrated an interval increase in number and size of segmental pleomorphic calcifications in the lower inner breast spanning 6 cm in size. A stereotactic core needle biopsy was completed and revealed high-grade ductal carcinoma in situ (DCIS) that was estrogen receptor (ER) and progesterone receptor (PR) positive. Surgical Treatment KS underwent genetic testing due to her young age at diagnosis of noninvasive breast cancer. She was tested with the breast/ovarian cancer panel, which was negative for mutation. She preceded to bilateral nipple-sparing mastectomy with left sentinel node biopsy and immediate implant reconstruction in February 2016. The operative pathology revealed 3.3 cm of high-grade DCIS. The surgical margins were negative (less than 1 mm posteriorly and less than 2 mm anteriorly). There was 1 sentinel node and 2 nonsentinel nodes negative for malignancy. The right breast was negative for cancer and both retro areolar margins were negative. KS did well during the ensuing routine follow-up every 6 to 12 months in surgical oncology at an academic medical center. She was not recommended to take adjuvant endocrine therapy given the benefit of bilateral mastectomy. In 2017, at a routine oncology follow-up visit, she expressed a desire to have more children. After a negative clinical exam, she and her husband were advised that future contraception may be pursued. Pregnancy-Associated Breast Cancer Diagnosis KS was in her usual state of good health when she noticed a left breast mass in the inferior reconstructed breast in June 2017. She presented to the nurse practitioner (NP) in the surgical oncology clinic for evaluation. At that time, she was 17 weeks pregnant and being seen in the same facility for high-risk obstetrics and gynecology care. KS had no other concerning symptoms for recurrent cancer, and her pregnancy had been progressing smoothly. The surgical oncology NP noted a 1-cm firm superficial mass in the breast at 6 o’clock. She had no other bilateral breast findings or adenopathy. Upon review of systems, she denied new persistent headache, shortness of breath, abdominal pain, weight loss, night sweats, or fatigue. Due to her pregnancy and the superficial presentation of the breast mass, a left breast ultrasound was ordered. It revealed an 8-mm irregular hypoechoic mass 7 cm from the nipple at the 6 o’clock position i...

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