Full T-cell activation and function in teleosts require collaboration of first and co-stimulatory signals
Wei Liang,
Kang Li,
Haiyou Gao
et al.
Abstract:Mammalian T-cell responses require synergism between the first signal and co-stimulatory signal. However, whether and how dual signaling regulates the T-cell response in early vertebrates remains unknown. In the present study, we discovered that the Nile tilapia (
Oreochromis
niloticus
) encodes key components of the LAT signalosome, namely, LAT, ITK, GRB2, VAV1, SLP-76, GADS, and PLC-γ1. These components are evolutionarily conserved, and CD3ε mAb-induced T-cell activation m… Show more
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