Full-spectrum fluorescent lighting: a review of its effects on physiology and health

McColl, Shelley L; Veitch, Jennifer A.

doi:10.1017/s0033291701004251

Cited by 74 publications

(26 citation statements)

References 118 publications

(114 reference statements)

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“…Over the past decade physiological and psychological effects of artificial fluorescent lighting on humans have been shown to be significant and quantifiable (McColl and Veitch, 2001). Both the amount of light and composition of lighting are important parameters associated with human health.…”

Section: Introductionmentioning

confidence: 99%

“…Differences in the in inflammatory response to specific light wavelengths have been shown between human males and females (Hurlbert and Ling, 2007; Vandewalle, et al, 2010). Other published reports suggest human physiological response to full spectrum vs. “cool white” lamps include differences in oxygen intake, heart rate, absorption of vitamins and minerals, etc (Wurtman, 1975a,b; Holick, 1996; McColl and Veitch, 2001). However, despite behavioral and physiological studies indicating artificial light sources are important to animal health, there exists a paucity of data regarding specific molecular genetic responses that occur in the intact animal upon exposure to varying types of artificial lighting.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin

Walter

Boswell

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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We report RNA-Seq results from skin of X. maculatus Jp 163 B after exposure to various doses of “cool white” fluorescent light (FL). We show that FL exposure incites a genetic transcriptional response in skin nearly as great as observed for UVB exposure; however, the gene sets modulated due to exposure to the two light sources are quite different. Known light responsive genes involved in maintaining circadian cycling (e.g., clock, cry2a, cry1b, per1b, per2, per3, arntl1a, etc.) exhibited expected shifts in transcriptional expression upon FL exposure. Exposure to FL also resulted in down-regulated transcription of many genes involved with cell cycle progression (e.g., cdc20, cdc45, cdca7b, plk1, cdk1, ccnb-3, cdca7a, etc.) and chromosome segregation (e.g., cenpe, cenpf, cenpi, cenpk, cenpo, cenpp, and cenpu; cep70; knstrm, kntc, mcm2, mcm5; smc2, etc.). In addition, several DNA replication and recombination repair genes (e.g., pola1, pole, rec52, rad54l, rpa1, parpbp, etc.) exhibit reduced expression in FL exposed X. maculatus skin. Some genes down modulated by FL are known to be associated with DNA repair and human diseases (e.g., atm2, brip1, fanc1, fancl, xrcc4, etc.). The overall suppression of genes involved with mitotic progression in the skin of adult fish is consistent with entry into the light phase of the circadian cycle. Current efforts are aimed at determining specific wavelengths that may lead to differential expression among the many genes affected by fluorescent light exposure.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin

Walter

Boswell

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…The audit tool was broad and included features of the church environment that have the potential to influence PA and HE, but without programming or prompts, the presence of features alone may not be adequate to influence these beliefs and behaviors. Additional features that may impact human comfort and health may also play a role in this relationship, such as indoor air quality [37,38], thermal comfort [39], noise levels [40], and lighting [41], that were not collected as a part of this study. Future research may measure these influences and account for them in subsequent analyses.…”

Section: Discussionmentioning

confidence: 99%

Objective Church Environment Audits and Attendee Perceptions of Healthy Eating and Physical Activity Supports within the Church Setting

Wende

Kaczynski

Bernhart

et al. 2020

IJERPH

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Interventions in faith-based settings are increasingly popular, due to their effectiveness for improving attendee health outcomes and behaviors. Little past research has examined the important role of the church environment in individual-level outcomes using objective environmental audits. This study examined associations between the objectively measured physical church environment and attendees’ perceptions of physical activity (PA) and healthy eating (HE) supports within the church environment, self-efficacy for PA and HE, and self-reported PA and HE behaviors. Data were collected via church audits and church attendee surveys in 54 churches in a rural, medically underserved county in South Carolina. Multi-level regression was used to analyze associations between the church environment and outcomes. Physical elements of churches were positively related to attendees’ perceptions of church environment supports for PA (B = 0.03, 95% CI = 0.01, 0.05) and HE (B = 0.05, 95% CI = 0.01, 0.09) and there was a significant interaction between perceptions of HE supports and HE church environment. Self-efficacy and behaviors for PA and HE did not show an association with the church environment. Future research should establish a temporal relationship between the church environment and these important constructs for improving health. Future faith-based interventions should apply infrastructure changes to the church environment to influence important mediating constructs to health behavior.

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“…Use of broad-spectrum artificial lighting has been shown to have the potential to produce adverse effects on human health, including depression, disturbed sleep–wake cycles, obesity, altered body temperature, and altered circadian rhythms [4,5,6,7,8,9,10,11]. However, little research has been conducted to determine genetic consequences, if any, from use of common artificial light sources.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio rerio, Oryzias latipes and Mus musculus)

Boswell

et al. 2019

Genes

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Fluorescent light (FL) has been utilized for ≈60 years and has become a common artificial light source under which animals, including humans, spend increasing amounts of time. Although the solar spectrum is quite dissimilar in both wavelengths and intensities, the genetic consequences of FL exposure have not been investigated. Herein, we present comparative RNA-Seq results that establish expression patterns within skin, brain, and liver for Danio rerio, Oryzias latipes, and the hairless mouse (Mus musculus) after exposure to FL. These animals represent diurnal and nocturnal lifestyles, and ≈450 million years of evolutionary divergence. In all three organisms, FL induced transcriptional changes of the acute phase response signaling pathway and modulated inflammation and innate immune responses. Our pathway and gene clustering analyses suggest cellular perception of oxidative stress is promoting induction of primary up-stream regulators IL1B and TNF. The skin and brain of the three animals as well as the liver of both fish models all exhibit increased inflammation and immune responses; however, the mouse liver suppressed the same pathways. Overall, the conserved nature of the genetic responses observed after FL exposure, among fishes and a mammal, suggest the presence of light responsive genetic circuitry deeply embedded in the vertebrate genome.

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Full-spectrum fluorescent lighting: a review of its effects on physiology and health

Cited by 74 publications

References 118 publications

Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin

Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin

Objective Church Environment Audits and Attendee Perceptions of Healthy Eating and Physical Activity Supports within the Church Setting

Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio rerio, Oryzias latipes and Mus musculus)

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