Full Scope of Effect of Facial Lipoatrophy: A Framework of Disease Understanding

Ascher, Benjamin; Coleman, Sydney R.; Alster, Tina S.; Bauer, Ute; Burgess, Cheryl; Butterwick, Kimberly J.; Donofrio, Lisa; Engelhard, Peter; Goldman, Mitchel P.; Katz, Philippe; Vleggaar, Danny

doi:10.1111/j.1524-4725.2006.32230.x

Cited by 61 publications

(69 citation statements)

References 31 publications

(54 reference statements)

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“…Facial morphology, patient age, and skin quality may affect how subcutaneous fat is outwardly perceived. 18 Patients and clinicians may perceive lipoatrophy differently, as patients may be less sensitive to small changes in facial or body shape over time. Clinicians, by contrast, see patients less frequently and may be more able to perceive changes.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Ultrasound for Use in Detecting Lipoatrophy in HIV-Infected Patients Taking Combination Antiretroviral Therapy

Višković

Richman²,

Klasnic³

et al. 2009

AIDS Patient Care and STDs

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The aim of this study was evaluation of ultrasound (US) as a tool for the assessment of lipoatrophy in a population of HIV-infected patients. We enrolled a convenience sample of 151 HIV-infected Caucasian participants (males, 79%) who were treated for at least 1 year with combination antiretroviral therapy (CART) in Zagreb, Croatia. US measurements of subcutaneous fat thickness were done over the malar, brachial, and crural region. We determined sensitivity and specificity of US as a diagnostic tool for lipoatrophy using receiver-operating curves and concordant patient and clinician assessment as our reference for the presence of lipoatrophy. HIV was acquired through heterosexual contact in 50% of participants and by sex between men in 42%. The mean current CD4 cell count was 503.1 cells=mm 3 (standard deviation [SD] ¼ 250.8). Seventy-seven (51%) participants were treated with stavudine and 91 (64%) with a protease inhibitor for at least 6 months. Nineteen (13%) participants had lipoatrophy in at least one anatomic site. Sensitivity of US ranged from 67%-71%, specificity from 65%-71%, positive and negative predictive values ranged from 11%-20% and 96-97%, respectively. USdiagnosed lipoatrophy was more frequently found in patients with a history of stavudine treatment and in females. Patients with lipoatrophy had a longer duration of CART than those without lipoatrophy. US is a useful tool in ruling out the presence of clinical lipoatrophy in patients on CART. Using this objective measure of subcutaneous fat may be useful in helping clinicians make decisions about changing therapy.

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Section: Discussionmentioning

confidence: 99%

Assessment of Ultrasound for Use in Detecting Lipoatrophy in HIV-Infected Patients Taking Combination Antiretroviral Therapy

Višković

Richman²,

Klasnic³

et al. 2009

AIDS Patient Care and STDs

View full text Add to dashboard Cite

show abstract

“…Much attention has been devoted recently to the multiple factors that contribute to facial aging. The former paradigm that gravity is the main contributor to skin laxity and an "aged" appearance has given way to new discovery that fat atrophy and bone resorption, particularly in the lower face, creates not only skin laxity but also a volume-loss phenomenon [35][36][37]. This being the case, one would be remiss not to address this loss of volume when undertaking facial rejuvenation.…”

Section: Combination Treatmentsmentioning

confidence: 99%

Fractional Ablative Resurfacing

Tournas

Zachary

2010

Facial Resurfacing

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“…Age-specific changes in facial soft tissues and their effects on facial morphology has been clearly decribed elsewhere [1][2][3] . Restoration of soft tissue through augmentation, modify facial contours, correct tissue loss associated with normal aging.…”

Section: Introductionmentioning

confidence: 99%

Permanent volumizing and contouring of the lower face using 350 centistokes injectable silicone

Ulusal¹

2018

PAR

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cp -the higher the number, the more viscous the oil. Most of the reports used 1000-cp silicone oil for filling purposes and due to high viscosity, only microdroplet injection technique is recommended to avoid complications. This is the first report of patient series using liquid silicone with a 350-cp viscosity The objective of this study was to explore the reliability and efficacy of low viscosity liquid silicone for lower face contour correction.Methods: Lower facial region of 43 patients including chin, nasolabial and melolabial regions were treated by low viscosity (350 cp) liquid silicone. Instead of microdroplet tehniqe, retrograde linear threading technique was used. Total injection volume was 6.0 ± 3.9 mL. At least two sessions were required for complete correction which are spaced one month apart.Overcorrection was avoided. The treated areas had a soft and natural feeling with no lumpiness and stiffness.Results: Mean follow-up period was 16.8 ± 14.3 months. The mean aesthetic satisfaction score was 4.51. No migration of the material was seen which is revealed by palpation and no major complication was encountered. None of the patients had any complaints regarding late facial deformity due to silicone migration. Conclusion:Low viscosity liquid silicone is effective, well-tolerated and easy to use. It can be used as an alternative to higher viscosity silicones to avoid technical errors and complications.

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Full Scope of Effect of Facial Lipoatrophy: A Framework of Disease Understanding

Cited by 61 publications

References 31 publications

Assessment of Ultrasound for Use in Detecting Lipoatrophy in HIV-Infected Patients Taking Combination Antiretroviral Therapy

Assessment of Ultrasound for Use in Detecting Lipoatrophy in HIV-Infected Patients Taking Combination Antiretroviral Therapy

Fractional Ablative Resurfacing

Permanent volumizing and contouring of the lower face using 350 centistokes injectable silicone

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