Full Regression of Peyronie’s Disease Plaque Following Combined Antioxidant Treatment: A Three-Case Report

Paulis, Gianni; Giorgio, Giovanni De

doi:10.3390/antiox11091661

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Even if the aim of this study was not the following, our results testified to the elimination of the plaque after antioxidant treatment, as other articles in the literature have already described [72][73][74][75].…”

Section: Discussionmentioning

confidence: 77%

Measurement of Oxidative Stress Index (OSI) in Penile Corpora Cavernosa and Peripheral Blood of Peyronie’s Disease Patients: A Report of 49 Cases

Paulis,

De Giorgio

et al. 2024

Metabolites

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Peyronie’s disease (PD) is a chronic inflammatory disease affecting the penile albuginea. Oxidative stress (OS) is important for the development of the disease; therefore, it seemed interesting to us to directly measure OS at both the site of the disease and in peripheral blood. For a precise OS study, it is necessary to evaluate not only the single results of the total oxidant status (TOS) and total antioxidant status (TAS) but also their ratio: OS index (OSI) (arbitrary unit) = TOS/TAS × 100. This study included 49 PD patients examined and diagnosed in our Peyronie’s care center and a control group of 50 cases. We collected blood samples from both the penis and a vein in the upper extremity; we used d-ROMs and PAT-test (FRAS kit) for OS measurement. Pearson’s study found a statistical correlation between penile OSI values and PD plaque volumes: p-value = 0.002. No correlation was found between systemic OSI values and PD plaque volumes: p-value = 0.27. Penile OSI values were significantly reduced after the elimination of the PD plaque (p < 0.00001). The mean value of the penile OSI indices in the PD patients after plaque elimination corresponded to 0.090 ± 0.016 (p = 0.004). The comparison between the penile OSI values of the PD patients (with plaque elimination) and the control group revealed no statistically significant differences (p = 0.130). The absence of a correlation between Peyronie’s plaque volume and systemic OSI values indicates that it is preferable to carry out the OS study by taking a sample directly from the site of the disease. By carrying out a penile OSI study, it would be possible to obtain a precise plaque-volume-dependent oxidative marker. Even if the study did not demonstrate any correlation between OSI indices and anxious–depressive state, we detected a high prevalence of anxiety (81.6%) and depression (59.1%) in PD patients.

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Section: Discussionmentioning

confidence: 77%

Measurement of Oxidative Stress Index (OSI) in Penile Corpora Cavernosa and Peripheral Blood of Peyronie’s Disease Patients: A Report of 49 Cases

Paulis,

De Giorgio

et al. 2024

Metabolites

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“…Recently, we published three case report articles, where we presented eight patients (in total) with PD whose plaque disappeared completely after multimodal antioxidant treatment [ 28 , 29 , 30 ]. There was no photographic documentation in these case reports.…”

Section: Discussionmentioning

confidence: 99%

Disappearance of Plaque Following Treatment with Antioxidants in Peyronie’s Disease Patients—A Report of 3 Cases

Paulis¹,

Giorgio²

2022

Clinics and Practice

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Peyronie’s disease (PD) is a fibrotic disorder of the penile tunica albuginea. To date, only a few cases of recovery from PD following medical treatment have been reported in the literature. In this article, we describe three new cases of PD where patients achieved complete resorption of plaque following multimodal antioxidant treatment. In all three cases, treatment included the following antioxidants: bilberry, propolis, ginkgo biloba, silymarin, and vitamin E. Only in case nos. 1 and 2 did we also use the following antioxidant substances: L-carnitine, coenzyme Q10, and Boswellia. In all three cases, we also used a local therapy with diclofenac gel. Only in case no. 2 did we also use periodic perilesional injections with pentoxifylline. Although the sample of cases presented here was small, these patients incontrovertibly experienced complete plaque disappearance and recovery (in one case, only after a short course of treatment). Therefore, it is our conviction that urologists may find our experiences of considerable interest in their clinical practices.

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“…More recently, Paulis et al published a case report of three cases that showed full plaque regression, curvature improvement, and resolution of pain with a combination of oral antioxidants and topical propolis crème in one case and with the addition of pentoxifylline injections in the other two cases. 97 The authors do not specify what phase of disease these patients were in but do report that full regression required between two and four years of therapy. Penile ultrasound was utilized to monitor plaque regression.…”

Section: Novel Therapies For Peyronie’s Diseasementioning

confidence: 99%

Peyronie’s Disease: An Outcomes-Based Guide to Non-Surgical and Novel Treatment Modalities

Reddy¹,

Dai²,

Song³

et al. 2023

RRU

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The clinical landscape of Peyronie’s disease is everchanging. There has been growing interest in non-invasive therapeutic options that could assist patients with achieving a meaningful reduction in penile curvature without surgical intervention. These therapies are wide-ranging in terms of their mechanisms of action, efficacies, and short- and long-term safety profiles. Recently, an abundance of outcomes literature on longstanding and novel non-surgical treatment modalities has been published. For sexual medicine providers hoping to offer patients the most up-to-date and evidence-based treatments for the management of Peyronie’s disease, it can be challenging to gain a thorough understanding of this body of literature. In this clinical management review, the workup and current theories on the pathophysiology of Peyronie’s disease are reviewed, and the most recent outcomes data on the currently available non-surgical treatment modalities are presented. With an accurate understanding of the current landscape of Peyronie’s disease treatment, sexual health providers will be able to better evaluate and engage in evidence-based shared decision-making with their patients.

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Full Regression of Peyronie’s Disease Plaque Following Combined Antioxidant Treatment: A Three-Case Report

Cited by 7 publications

References 31 publications

Measurement of Oxidative Stress Index (OSI) in Penile Corpora Cavernosa and Peripheral Blood of Peyronie’s Disease Patients: A Report of 49 Cases

Measurement of Oxidative Stress Index (OSI) in Penile Corpora Cavernosa and Peripheral Blood of Peyronie’s Disease Patients: A Report of 49 Cases

Disappearance of Plaque Following Treatment with Antioxidants in Peyronie’s Disease Patients—A Report of 3 Cases

Peyronie’s Disease: An Outcomes-Based Guide to Non-Surgical and Novel Treatment Modalities

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