Full-Range Liver Fat Fraction Estimation in Magnitude MRI Using a Signal Shape Descriptor

Abstract

Current methods for estimation of proton density fat fraction (PDFF) of the liver using magnitude magnetic resonance (MR) imaging face the challenge of correctly estimating it when fat is the dominant molecule; i.e., PDFF is more than 50%. Therefore, the accuracy of the methods is limited to half-range operation. We introduce a method based on neural networks for regression capable of estimating over the full range of fat fractions. We built a neural network based on the angles and distances between the data in the discrete MR signal (ADALIFE), using these as features associated with different PDFFs and as input for the network. Tests were performed using ADALIFE and Multi-interference, a state-of-the-art method to estimate PDFFs, with simulated signals at various signal-to-noise (SNR) values. Results were compared in order to verify repeatability and agreement using Bland-Altman and REC curves. Results for Multi-interference were similar to its in vivo literature, showing the relevance of a simulation. ADALIFE was able to correctly estimate fat fractions up to 100%, breaking the current paradigm for full-range estimation using only offline postprocessing. Within half range, our method outperformed Multi-interference in repeatability and agreement, with narrower limits of agreement and lower expected error at any SNR.