Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease)

El-Asrar, A M Abu; Al-Kharashi, Soliman A

doi:10.1136/bjo.86.11.1248

Cited by 57 publications

(41 citation statements)

References 9 publications

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“…Currently, Eales' disease is in essence a diagnosis of exclusion of the diseases that are known to be associated with retinal vasculitis. [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] Epiretinal membranes obtained from the patients with Eales' disease could form a good specimen to study the aetiopathogenesis. 7 In its proliferative stages, Eales' disease mimics other vasoproliferative disorders like diabetic retinopathy and vascular occlusions.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

Majji

Vemuganti

Shah

et al. 2005

Eye

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Section: Discussionmentioning

confidence: 99%

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

Majji

Vemuganti

Shah

et al. 2005

Eye

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“…Some cases require vitreoretinal surgery for VH and tractional complications; surgical results have been variable in the published literature. 1,[5][6][7][8] Though satisfactory overall results have been claimed, 1 the reported outcomes differ considerably with the surgical indication (VH vs tractional complications), the extent of posterior vitreous detachment (PVD), and even surgical techniques. [5][6][7][8][9][10] Some of the largest surgical studies are over two decades' old; 7,8 the recent ones are small.…”

Section: Introductionmentioning

confidence: 99%

“…1,[5][6][7][8] Though satisfactory overall results have been claimed, 1 the reported outcomes differ considerably with the surgical indication (VH vs tractional complications), the extent of posterior vitreous detachment (PVD), and even surgical techniques. [5][6][7][8][9][10] Some of the largest surgical studies are over two decades' old; 7,8 the recent ones are small. 5,6,[9][10][11] The effect of surgical variables like PVD, retinal detachments (RD), and intraoperative procedures on the final outcome have not been evaluated in a controlled manner.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8][9][10] Some of the largest surgical studies are over two decades' old; 7,8 the recent ones are small. 5,6,[9][10][11] The effect of surgical variables like PVD, retinal detachments (RD), and intraoperative procedures on the final outcome have not been evaluated in a controlled manner. We present our long-term surgical experience with Eales' disease; and analyse the influence of preoperative and surgical variables on anatomical and visual outcome.…”

Section: Introductionmentioning

confidence: 99%

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Surgical outcomes for vitrectomy in Eales' disease

Shukla

Kanungo

Prasad

et al. 2007

Eye

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Aim To present and analyse the anatomical and functional outcomes for vitrectomy in Eales' disease. Methods This retrospective case series enrolled 63 patients (71 eyes) who underwent pars plana vitrectomy (PPV) for the complications of Eales' disease. Indications included nonclearing vitreous haemorrhage (VH) with/without epiretinal membranes in 49 (69%) eyes, and retinal detachments (RD) involving/threatening macula in 22 (31%). Additional procedures (scleral buckling; gas/oil tamponade) were performed at surgeon's discretion. Minimum follow-up was 6 months. The primary outcome measures were change in best-corrected visual acuity (BCVA) and posterior segment status. Results The mean age of the patients was 29.6 years (range: 15-70 years); 60 were male (95%). Preoperatively, posterior vitreous detachment (PVD) existed in 28 (39.4%) eyes. Forty (56.3%) eyes underwent only PPV; the rest required additional surgical procedures (q.v.). The mean baseline BCVA (1/60) improved to 6/24 postoperatively (Po0.0001). Fifty-four eyes of 50 patients (76%) showed an improvement of X2 equivalent Snellen lines; six eyes (four patients) remained stable (71 line); visual acuity worsened in 11 eyes (nine patients). The mean final BCVA was similar in eyes operated for VH and RD (P ¼ 0.08); but the magnitude of change from baseline was greater in the VH group (P ¼ 0.009). PVD had a borderline association with final BCVA (P ¼ 0.056); but did not influence the functional/anatomical improvement. Thirteen eyes required repeat interventions; 11 (15.49%) eyes experienced surgical failure. Conclusions Although surgical outcomes in Eales' disease depend on preoperative PVD/RD to some extent; good results are possible in the presence of incomplete PVD and tractional sequelae.

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“…2 Many previous studies have revealed the role of human leukocyte antigen, retinal autoimmunity, mycobacterium tuberculosis genome, and free radical mediated damage in the aetiopathogenesis of this disease. [20][21][22][23][24][25] Impaired Th1/Th2 balance has been linked to numerous diseases caused by a variety of stresses. [26][27][28][29] Therefore, it is noteworthy to investigate whether the Th1/Th2 imbalance could play a central role in the onset of ED.…”

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confidence: 99%

Serum interferon‐gamma/interleukin‐4 imbalance in patients with Eales' disease

Gong

Wei

Zhang

et al. 2010

Clinical and Experimental Optometry

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Background: Eales' disease (ED) is an idiopathic obliterative vasculopathy that usually affects the peripheral retina of young adults. The aim of this study is to investigate Th1/Th2 serum cytokine profiling in patients with ED. Methods: This study included 30 male patients with ED and 10 healthy controls. The ED patients were divided into two subgroups: the vitreous haemorrhage (VH) group (n = 18) and non-vitreous haemorrhage (NVH) group (n = 12). Sixteen patients (six from the VH group and 10 from the NVH group) received glucocorticoid treatment for three months and were followed for six months. Levels of six cytokines including interferon-gamma (IFN-g), tumour necrosis factor-alpha (TNF-a) and four interleukins (IL-2, IL-4, IL-5 and IL-10) in the serum samples were determined by Luminex assays. Results: Compared to controls, ED patients showed significantly higher levels of IL-10 and TNF-a, increased IFN-g/IL-4 (Th1/Th2) ratio, and lower levels of IL-4 (p < 0.05). Glucocorticoid treatment caused a restoration in the cytokine levels and the IFN-g/IL-4 ratio. Multivariate analysis revealed that reduced IL-4 (less than 4 pg/ml) and elevated IL-10 (greater than 4 pg/ml) levels were independent predictors of ED with odds ratios of 0.024 (95% CI, 0.002-0.255; p = 0.002) and 12.108 (95% CI, 1.045-140.233; p = 0.046), respectively. Conclusion:The findings demonstrate for the first time that there is an imbalance of Th1/Th2 cytokines in ED patients, which can be reversed by glucocorticoid treatment. Additionally, both IL-4 and IL-10 might represent potential diagnostic markers for the disease.

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Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease)

Cited by 57 publications

References 9 publications

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

Surgical outcomes for vitrectomy in Eales' disease

Serum interferon‐gamma/interleukin‐4 imbalance in patients with Eales' disease

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