Full: Ontogenesis and development of the nonhuman primate pulvinar

Homman‐Ludiye, Jihane; Kwan, William C.; Souza, Mitchell J. de; Bourne, James A.

doi:10.1002/cne.24534

Cited by 13 publications

(11 citation statements)

References 24 publications

(47 reference statements)

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“…In this context, Homman‐Ludiye and colleagues recently identified in the embryonic mouse dorsal thalamus, cell clusters expressing genes specifically enriched in the neonatal marmoset PM (Homman‐Ludiye et al. ), suggesting that the origin of the PM could be traced back beyond the primate lineage.…”

Section: Origin Of the Pmmentioning

confidence: 99%

“…However, a recent study in the marmoset monkey ( C. jacchus ) demonstrated that pulvinar neurones are still being generated a few days before birth (Homman‐Ludiye et al. ), suggesting that ontogenesis of the pulvinar is more similar across primates than originally believed. Despite pulvinar neurogenesis spanning the entire period of brain development in the marmoset, there is no evidence of a second telencephalic wave of neurones.…”

Section: Origin Of the Pmmentioning

confidence: 99%

“…In the marmoset ( C. jacchus ), visual pulvinar nuclei PI and PL acquire their adult‐like profile around 2 weeks postnatally, whereas the Cb profile in PM is still immature at 3 months of age (Homman‐Ludiye et al. ). This sequence appears to parallel the sequential maturation of the respective cortical areas with which the pulvinar nuclei connect, with occipital areas maturing early, and frontal and parietal areas maturing last, as demonstrated in marmosets ( C. jacchus ) and humans (Gogtay et al.…”

Section: Origin Of the Pmmentioning

confidence: 99%

“…A recent analysis of the genetic signature of the neonatal marmoset dorsal thalamus notably revealed expression of AUTS2 in the pulvinar complex (Homman‐Ludiye et al. ), suggesting that its development could be impaired in individuals carrying a faulty allele. Research into how the structure and functions of the PM are affected in patients has the potential to identify much needed therapeutic targets and enable differential diagnosis within the spectrum of disorders.…”

Section: Association With Neurodevelopmental Disordersmentioning

confidence: 99%

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The medial pulvinar: function, origin and association with neurodevelopmental disorders

Homman‐Ludiye

Bourne

2019

Journal of Anatomy

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The pulvinar is primarily referred to for its role in visual processing. However, the 'visual pulvinar' only encompasses the inferior and lateral regions of this complex thalamic nucleus. The remaining medial portion (medial pulvinar, PM) establishes distinct cortical connectivity and has been associated with directed attention, executive functions and working memory. These functions are particularly impaired in neurodevelopmental disorders, including schizophrenia and attention deficit and hyperactivity disorder (ADHD), both of which have been associated with abnormal PM architecture and connectivity. With these disorders becoming more prevalent in modern societies, we review the literature to better understand how the PM can participate in the pathophysiology of cognitive disorders and how a better understanding of the development and function of this thalamic nucleus, which is most likely exclusive to the primate brain, can advance clinical research and treatments.

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Section: Origin Of the Pmmentioning

confidence: 99%

Section: Origin Of the Pmmentioning

confidence: 99%

Section: Origin Of the Pmmentioning

confidence: 99%

Section: Association With Neurodevelopmental Disordersmentioning

confidence: 99%

See 2 more Smart Citations

The medial pulvinar: function, origin and association with neurodevelopmental disorders

Homman‐Ludiye

Bourne

2019

Journal of Anatomy

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“…Nissl and Acetylcholine-esterase staining protocols were performed on slide-mounted sections as previously described (Homman-Ludiye et al, 2018).…”

Section: Histological Stainingmentioning

confidence: 99%

A Hox code defines spinocerebellar neuron subtype regionalisation

Coughlan

Garside

Wong

et al. 2019

Preprint

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Coordinated body movement requires the integration of many sensory inputs. This includes proprioception, the sense of relative body position and force associated with movement.Proprioceptive information is relayed to the cerebellum via spinocerebellar neurons, located in the spinal cord within a number of major neuronal columns or as various scattered cell populations. Despite the importance of proprioception to fluid movement, a molecular understanding of spinocerebellar relay interneurons is only beginning to be explored, with limited knowledge of molecular heterogeneity within and between columns. Using fluorescent reporter knock-in mice, neuronal tracing and in situ hybridisation, we identify widespread expression of Hox cluster genes, including both protein-coding genes and microRNAs, within spinocerebellar neurons. We reveal a "Hox code" based on axial level and individual spinocerebellar column, which, at cervico-thoracic levels, is essential for subtype regionalisation. Specifically, we show that Hoxc9 function is required in most, but not all, cells of the major thoracic spinocerebellar column, Clarke's column, revealing heterogeneity reliant on Hox signatures.

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Development of the thalamus: From early patterning to regulation of cortical functions

Nakagawa

2019

WIREs Developmental Biology

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The thalamus is a brain structure of the vertebrate diencephalon that plays a central role in regulating diverse functions of the cerebral cortex. In traditional view of vertebrate neuroanatomy, the thalamus includes three regions, dorsal thalamus, ventral thalamus, and epithalamus. Recent molecular embryological studies have redefined the thalamus and the associated axial nomenclature of the diencephalon in the context of forebrain patterning. This new view has provided a useful conceptual framework for studies on molecular mechanisms of patterning, neurogenesis and fate specification in the thalamus as well as the guidance mechanisms for thalamocortical axons. Additionally, the availability of genetic tools in mice has led to important findings on how thalamic development is linked to the development of other brain regions, particularly the cerebral cortex. This article will give an overview of the organization of the embryonic thalamus and how progenitor cells in the thalamus generate neurons that are organized into discrete nuclei. I will then discuss how thalamic development is orchestrated with the development of the cerebral cortex and other brain regions. This article is categorized under: Nervous System Development > Vertebrates: Regional Development Nervous System Development > Vertebrates: General Principles

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Full: Ontogenesis and development of the nonhuman primate pulvinar

Cited by 13 publications

References 24 publications

The medial pulvinar: function, origin and association with neurodevelopmental disorders

The medial pulvinar: function, origin and association with neurodevelopmental disorders

A Hox code defines spinocerebellar neuron subtype regionalisation

Development of the thalamus: From early patterning to regulation of cortical functions

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