Full method validation for the determination of hexachlorobenzene and hexachlorobutadiene in fish tissue by GC–IDMS

Majoros, Laszlo; Lava, Roberto; Ricci, Marina; Binici, Burcu; Sandor, Florian; Held, Andrea; Emons, Hendrik

doi:10.1016/j.talanta.2013.04.080

Cited by 12 publications

(7 citation statements)

References 27 publications

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“…and the hexane:dichloromethane solvent mixture routinely used for these contaminants (Fernandes et al, 2004) proved equally effective here. Other studies on these compounds (Lacorte et al, 2006;Majoros et al, 2013), also report using similar extraction solvents. The first stage of ACCEPTED MANUSCRIPT…”

Section: Methods Development and Validationmentioning

confidence: 86%

Recently listed Stockholm convention POPs: Analytical methodology, occurrence in food and dietary exposure

Fernandes

Mortimer

Rose

et al. 2019

Science of The Total Environment

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In recent years, the Stockholm Convention has listed an additional set of persistent organic pollutants (POPs) for elimination or restricted use/release. Data on the occurrence of these contaminants in food is scarce. Validated analytical methodology was developed to investigate the occurrence of hexachlorobutadiene (HCBD), pentachlorobenzene (PCBz), hexachlorobenzene (HCB) pentachlorophenol (PCP) and polychlorinated naphthalenes (PCNs) in 120 retail foods and 19 total diet study samples. The foods covered the range of commonly consumed dietary items including dairy products, eggs (hen and other species), poultry, meat, fish, vegetables, etc. HCBD showed a low frequency of detection, whereas PCBz, HCB and PCNs occurred in most samples (ranges: <0.01 to 0.19 µg/kg; <0.01 to 3.16 µg/kg and 0.1 to 166 ng PCNs/kg respectively). PCP (<0.01 to 1.9 µg/kg) was detected more frequently in meat products, offal and eggs. Fish, shellfish, eggs from all species, animal fats, meat, offal and meat products showed higher contamination levels, which is normal when investigating lipophilic POPs. These levels of occurrence are similar to more recently reported literature levels but perhaps lower, relative to historic data. This is not unexpected, given the restrictions/limitations on these chemicals within the UK and Western Europe. The estimated human exposure to population groups through dietary intake is correspondingly low and based on current toxicological knowledge, the levels in the examined samples do not suggest a cause for health concern. The data also provide a current

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Section: Methods Development and Validationmentioning

confidence: 86%

Recently listed Stockholm convention POPs: Analytical methodology, occurrence in food and dietary exposure

Fernandes

Mortimer

Rose

et al. 2019

Science of The Total Environment

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“…Such situations seem also similar in other fields of analytical chemistry from 1990s to nowadays; many papers related to SAM have appeared in environmental chemistry [57][58][59][60][61][62][63][64], food chemistry [65][66][67][68], clinical chemistry [69][70][71] and miscellaneous fields [72][73][74][75][76][77][78][79][80][81]. The validation approaches in non-forensic toxicology fields were also of various types like those of forensic toxicology as listed in Table 1.…”

Section: Discussionmentioning

confidence: 77%

The standard addition method and its validation in forensic toxicology

et al. 2021

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Purpose In the quantitative forensic toxicological analyses using instruments, major methods to be employed are conventional matrix-matched calibration method (MMCM). However, nowadays, the needs for using the standard addition methods (SAM) are increasing. In spite of this situation, there are no reports of the guidelines for the validations of SAM. In this review, the principle, how to perform it, advantages, disadvantages, reported application data, and the details of validation procedures for the SAM are described. Methods Various databases such as SciFinder, Google and Google Scholar were utilized to collect relevant reports referring to the SAM. The long experiences of our research group on the SAM were also included in this review. Results Although the experimental procedures for the SAM are much more laborious than those of the MMCM, the SAM is essential to quantify target xenobiotic(s) in special matrices such as human solid tissues or biles, which remarkably interfere with the usual quantitative analyses. The validation methods for the SAM have been also proposed for the cases in the absence of the blank matrices. Conclusions To our knowledge, this is the first presentation of detailed SAM procedure and its validation, which will facilitate the use of the SAM in forensic toxicology. Especially for its validation, new simple methods have been proposed.

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“…HCB is a chlorocarbon, formerly used as a seed treatment (fungicide), wood preserving agent and it is a byproduct in many industrial processes. HCB has been applied as a porosity control agent in the manufacturing of graphite anodes, as a fluxing agent in the production of aluminum, as a peptizing agent in the manufacturing of nitroso and styrene rubber for tires, and as a chemical intermediate in dye manufacturing [5]. It has been banned globally under the Stockholm Convention on persistent organic pollutants (POPs) [6,7].…”

Section: Review Of Environment and Earth Sciencesmentioning

confidence: 99%

“…The analytical instruments commonly used for the detection and quantification of agrochemicals and PCPs are: high performance liquid chromatography (HPLC), gas chromatography isotopic dilution mass spectrometer (GC-IDMS), gas chromatography-mass spectrometer (GC-MS), gas chromatography-electron capture detector (GC-ECD) and ultraviolet (UV) visible spectrophotometer (UV-vis). Kim, et al [4] microextraction using octadecyl-bonded silica immobilized on the surface of a rotating disk, Zheng, et al [27] analyzed HCB and its dechlorination intermediates by a Hewlett-Packard 6890 GC equipped with ECD, while Majoros, et al [5] used accelerated solvent extraction (ASE) followed by column clean-up and GC-IDMS for the separation and detection of HCB. The concentration of DDT in the aqueous phase was analyzed by Cao, et al [13] with the use of GC-ECD while Kulovaara, et al [10], Gautam and Suresh [14] and Liu and Xu [28] used GC-MS.…”

Section: Detection and Quantification Of Agrochemicals And Pcpsmentioning

confidence: 99%

Agrochemicals and Personal Care Products: Occurrence, Effects, Analytical Determination and Treatment Processes

Ayanda

2014

Review of Environment and Earth Sciences

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Pollution caused by agrochemicals and personal care products (PCPs) remains a severe problem worldwide. Runoff of agrochemicals from farms leads to contamination of the surface water and groundwater whilePCPs are discharged through laundering, washing and bathing. PCPs enter the municipal wastewater treatment plants and are incompletely removed during wastewater treatment. To reduce or eliminate the negative impact of these pollutants to human beings, animals, organisms and the environment, water should be well treated and wastewater should be treated to zero release before discharge into the environment. In this study, the occurrence, toxic effects, analytical determination and treatment processes of agrochemicals and PCPs in water and wastewater will be presented. This review will serve as valuable literature for researchers, policy makers, and environmental pollution consultants. Moreover, it will open the door to significant discussion on agrochemicals and PCPs.

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Full method validation for the determination of hexachlorobenzene and hexachlorobutadiene in fish tissue by GC–IDMS

Cited by 12 publications

References 27 publications

Recently listed Stockholm convention POPs: Analytical methodology, occurrence in food and dietary exposure

Recently listed Stockholm convention POPs: Analytical methodology, occurrence in food and dietary exposure

The standard addition method and its validation in forensic toxicology

Agrochemicals and Personal Care Products: Occurrence, Effects, Analytical Determination and Treatment Processes

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