Full-Length NAD+-I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate
Yoshita Srivastava,
Maya E. Blau,
Jermaine L. Jenkins
et al.
Abstract:Bacterial riboswitches are structured RNAs that bind small metabolites to control downstream gene expression. Two riboswitch classes have been reported to sense nicotinamide adenine dinucleotide (NAD + ), which plays a key redox role in cellular metabolism. The NAD + -I (class I) riboswitch stands out because it comprises two homologous, tandemly arranged domains. However, previous studies examined the isolated domains rather than the fulllength riboswitch. Crystallography and ligand binding analyses led to th… Show more
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