Full-genome sequences of GII.13[P21] recombinant norovirus strains from an outbreak in Changsha, China

Huang, Zheng; Dong, Yushu; Xiao, Shan; Yang, Dong; Ou, Xin-Hua

doi:10.1007/s00705-020-04643-1

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Norovirus continues to evolve in humans through both mutation and recombination, in particular, recombination appears to be a major force driving virus evolution [ 8 ]. Novel norovirus strains have emerged, and some classified into new tentative genogroups and genotypes [ 9 – 11 ]. In the past years, we also had studied the evolution of norovirus open reading frame 2 (ORF2), utilizing strains derived from population-based surveillance, and detected far more mutations than recombination events in RNA-dependent RNA polymerase (RdRp) region of ORF1 [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants

Chen

Wang

et al. 2023

Virol J

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Background Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission. Methods We conducted the first norovirus molecular epidemiology analysis covering both symptomatic and asymptomatic infections derived from a birth cohort study in the northern China. Results During the study, 14 symptomatic and 20 asymptomatic norovirus infections were detected in 32 infants. Out of the 14 strains that caused symptomatic infections, 12 strains were identified as GII.3[P12], and others were GII.4[P31]. Conversely, 17 asymptomatic infections were caused by GII.4[P31], two by GII.2[P16], and one by GII.4[P16]. Regardless of symptomatic and asymptomatic infections, the mutations were detected frequently in the ORF2 region, and almost all recombination were identified in the RdRp-ORF2 region. The majority of the mutations were located around the predefined epitope regions of P2 subdomain indicating a potential for immune evasion. Conclusion The role of symptomatic as well as asymptomatic infections in the evolution of norovirus needs to be evaluated continuously.

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Section: Introductionmentioning

confidence: 99%

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants

Chen

Wang

et al. 2023

Virol J

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“…described, and some of them have been classi ed into new tentative genogroups and genotypes [9][10][11].…”

mentioning

confidence: 99%

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants

Chen

Wang

et al. 2022

Preprint

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Background: Norovirus, is the leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the ORF2 for norovirus. However, strains causing asymptomatic infection were not considered. Methods: we conduct the first norovirus molecular epidemiology analysis covering both symptomatic and asymptomatic infections derived from a birth cohort study in the northern China. Results: During the study, 14 symptomatic and 20 asymptomatic norovirus infections were detected in 32 infants. Out of the 14 strains that caused symptomatic infections, 12 strains were identified as GII.3 [P12], and others were GII.4 [P31]; conversely, 17 asymptomatic infections were caused by GII.4 [P31], two by GII.2 [P16], and one by GII.4 [P16]. Regardless whether symptomatic and asymptomatic the mutations were detected frequently in the ORF2 region, and almost all recombinations were identified in the RdRp region. The majority of the mutations were located around the predefined epitope regions of P2 subdomain indicating a potential for immune evasion. Conclusion: The role of asymptomatic infection in the evolution of noroviruses needs to be evaluated continuously.

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Seasonal occurrence and abundance of norovirus in pre- and postharvest lettuce samples in Nanjing, China

Xie¹,

Du²,

Li³

et al. 2021

LWT

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Full-genome sequences of GII.13[P21] recombinant norovirus strains from an outbreak in Changsha, China

Cited by 3 publications

References 31 publications

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants

Seasonal occurrence and abundance of norovirus in pre- and postharvest lettuce samples in Nanjing, China

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