Full characterization and cytotoxic activity of new silver(<scp>i</scp>) and copper(<scp>i</scp>) helicates with quaterpyridine

Adamski, Ariel; Fik, Marta A.; Kubicki, Maciej; Hnatejko, Zbigniew; Gurda, Dorota; Fedoruk-Wyszomirska, Agnieszka; Wyszko, Eliza; Kruszka, Dariusz; Dutkiewicz, Zbigniew; Patroniak, Violetta

doi:10.1039/c5nj03601a

Cited by 23 publications

(29 citation statements)

References 60 publications

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“…In contrast to the three-dimensional architectures just covered, M 2 L 3 helicates and flexicates consisting of two metal ions and three or four bridging ligands,typically do not have any significant internal binding space. [100][101][102][103][104] Flexicates are defined as distinct from helicates as they do not possess arigid linker that mechanically couples the chirality at the metal centres.I nstead they employ flexible linkers in combination with stereochemically programmed metal centres to generate diastereomerically pure complexes. [105] Despite the absence of any internal binding space,metalorganic helicates and flexicates,h ave shown promising medicinal properties,insome cases attributed to their ability to bind strongly to DNAa saresult of their complementary size and shape.Like many inorganic complexes with demonstrable medicinal properties,biological studies with helicates and flexicates are frequently performed in aqueous solutions containing trace DMSO or ethanol, and solubility in pure aqueous solution has-to the best of our knowledge-not been reported.…”

Section: Bioactive M 2 L 3 Complexesmentioning

confidence: 99%

Self‐Assembly of Functional Discrete Three‐Dimensional Architectures in Water

2018

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Construction of discrete, self-assembled architectures in water has gained significant interest in recent years as a wide range of applications arises from their defined 3D structure. In this review we jointly discuss the efforts of supramolecular chemists and biotechnologists who previously worked independently, to tackle discipline-specific challenges associated with construction of assemblies from synthetic and bio-derived components, respectively. Going forward, a more interdisciplinary research approach will expedite development of complexes with real-world applications that exploit the benefits of compartmentalisation. In support of this, we summarise advances made in the development of discrete, water-soluble assemblies, with particular focus on their current and prospective applications. Areas where understanding and methodologies can be transferred from one sector to the adjacent field are highlighted in anticipation this will yield advances not possible from either field alone.

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Section: Bioactive M 2 L 3 Complexesmentioning

confidence: 99%

Self‐Assembly of Functional Discrete Three‐Dimensional Architectures in Water

2018

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“…The chemical and biological activities of triazole ligands are of great interest for the preparation of metal complexes . Furthermore, metal complexes containing triazole ligands also show biological activities .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural characterization, density functional theory (B3LYP) calculations, thermal behaviour, docking and antimicrobial activity of 4‐amino‐5‐(heptadec‐8‐en‐1‐yl)‐4H‐1,2,4‐triazole‐3‐thiol and its metal chelates

Zayed

Salam

et al. 2018

Applied Organom Chemis

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Synthesis, structural characterization, density functional theory (B3LYP) calculations, thermal behaviour, docking and antimicrobial activity of 4-amino-5-(heptadec-8-en-1-yl)-4H-1,2,4-triazole-3-thiol and its metal chelatesThe structure of prepared triazole ligand 4-amino-5-(heptadec-8-en-1-yl)-4H-1,2,4-triazole-3-thiol and its coordination behaviour towards transition metal ions Ni (II), Co (II), Fe (III), Cd (II) and Cu (II) have been studied using magnetic measurements, elemental analyses and electronic, Fourier transform infrared and 1 H NMR spectroscopies. The thermal behaviours of the triazole ligand and its chelates were investigated and their thermal decomposition possibilities are proposed. The stages of all thermal decompositions are discussed.The Gaussian09 program was used to optimize the structural formula for the triazole ligand. Applying the DFT/B3LYP/6-311 basis set method, important theoretical parameters were calculated. The target triazole and its metal chelates were investigated in vitro against Escherichia coli, Staphylococcus aurous, Aspergillus flavus and Candida albicans, and were found to exhibit good antimicrobial activity. These results were confirmed using theoretical molecular docking.

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“…Im Unterschied zu den eben behandelten 3D‐Architekturen haben M 2 L 3 ‐Helikate und ‐flexikate, die aus zwei Metallionen und drei oder vier verbrückenden Liganden bestehen, normalerweise keinen nennenswerten internen Bindungsraum . Flexikate sind von den Helikaten abgegrenzt, da sie keinen starren Linker enthalten, der die Chiralität an den Metallzentren mechanisch koppelt.…”

Section: Synthetische Anordnungenunclassified

Selbstorganisation von funktionellen diskreten dreidimensionalen Architekturen in Wasser

Taylor¹,

Riddell²,

Smulders

2018

Angewandte Chemie

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Der Aufbau von diskreten, selbstorganisierten Architekturen in Wasser fand in den vergangenen Jahren erhebliches Interesse, da sich eine große Anzahl von Anwendungen aus ihrer definierten 3D‐Struktur ergibt. Dieser Aufsatz diskutiert die gemeinsamen Bemühungen von Chemikern aus der supramolekularen Chemie und von Biotechnologen zur Lösung fachspezifischer Aufgaben, die mit dem Aufbau von Anordnungen aus synthetischen bzw. biologisch abgeleiteten Komponenten verbunden sind. In Zukunft wird ein stärker interdisziplinärer Forschungsansatz die Entwicklung von Komplexen mit realen Anwendungen beschleunigen, welche die Vorteile der Kompartimentierung nutzen. Um dies zu unterstützen, sollen hier die Fortschritte zusammengefasst werden, die bei der Entwicklung diskreter, wasserlöslicher Anordnungen erzielt wurden, unter besonderer Berücksichtigung ihrer aktuellen und zukünftigen Anwendungen. Bereiche, in denen das Verständnis und die Methodik von einem auf das andere Gebiet übertragbar sind, werden hervorgehoben, mit der Hoffnung, dass dies zu Fortschritten führt, die auf beiden Gebieten allein nicht möglich wären.

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Full characterization and cytotoxic activity of new silver(i) and copper(i) helicates with quaterpyridine

Abstract: DNA binding and cells' cycle disorders caused by four new dinuclear Ag(i) and Cu(i) double helicates with quaterpyridine ligands.

Cited by 23 publications

References 60 publications

Self‐Assembly of Functional Discrete Three‐Dimensional Architectures in Water

Self‐Assembly of Functional Discrete Three‐Dimensional Architectures in Water

Synthesis, structural characterization, density functional theory (B3LYP) calculations, thermal behaviour, docking and antimicrobial activity of 4‐amino‐5‐(heptadec‐8‐en‐1‐yl)‐4H‐1,2,4‐triazole‐3‐thiol and its metal chelates

Selbstorganisation von funktionellen diskreten dreidimensionalen Architekturen in Wasser

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