Full Adherence to HAART: Is It Really Necessary?

Cainelli, Francesca

doi:10.1001/archinte.162.8.944

Archives of Internal Medicine

2002

DOI: 10.1001/archinte.162.8.944

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Full Adherence to HAART: Is It Really Necessary?

Francesca Cainelli¹

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Cited by 2 publications

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“…Selective drug pressure in the setting of high but imperfect levels of adherence suppresses wild‐type HIV such that the less‐fit drug‐resistant variant persists. This is consistent with preliminary observations that CD4 cell increases (a better marker for disease progression than HIV viral load) occur at levels of adherence lower than those required for complete viral suppression 30 …”

supporting

confidence: 92%

Is average adherence to HIV antiretroviral therapy enough?

Bangsberg

Deeks

2002

J Gen Intern Med

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supporting

confidence: 92%

Is average adherence to HIV antiretroviral therapy enough?

Bangsberg

Deeks

2002

J Gen Intern Med

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A Family Group Approach to Increasing Adherence to Therapy in HIV-Infected Youths: Results of a Pilot Project

Lyon

Trexler

Akpan-Townsend

et al. 2003

AIDS Patient Care and STDs

102

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This paper describes the development of a novel, pilot program in which a combined family group and peer approach were used to increase adherence to antiretroviral therapy in HIV-infected youths. Twenty-three HIV-positive youths, 15-22 years of age and 23 family members or "treatment buddies" participated in one of three 12-week programs. The intervention had six biweekly family and youth education sessions and six biweekly youth-only education sessions. Devices to increase adherence to antiretroviral therapy such as pill boxes, calendars, and watch alarms were introduced at youth-only sessions. Eighteen of the 23 youths completed a group. Ninety-one percent of youths self-reported increased adherence to medications after completion of a group. Four participants experienced a one-log reduction in viral loads to undetectable levels during the intervention. Two participants continued to decline antiretroviral medications at the end of the intervention and demonstrated no decrease in viral load. Participants tested five devices and rated the multiple alarm watch as the best aid for improving adherence to medication. Family/treatment buddies rated the overall program as highly helpful, citing social support as most valuable. An unanticipated benefit was an increase in other health behaviors, including medical and dental appointments, hepatitis B and influenza immunizations, and referrals to mental health and substance abuse treatment.

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Full Adherence to HAART: Is It Really Necessary?

Cited by 2 publications

References 11 publications

Is average adherence to HIV antiretroviral therapy enough?

Is average adherence to HIV antiretroviral therapy enough?

A Family Group Approach to Increasing Adherence to Therapy in HIV-Infected Youths: Results of a Pilot Project

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