Führen Fibrinklebermanschetten zur Fibrosierung von Nerventransplantaten?

Abstract

Although fibrin adhesion is being used in many areas of surgery with increasing success, it has not, however, become fully established in nerve anastomosis. It was in this area particularly that significant advantages were expected. As the fibrin clot dissolved prematurely, however, and dehiscences ensued, antifibrinolytic substances had to be added to the adhesive. Fibroses occurred frequently as a result, which to date hamper its use as a nerve adhesive. We examined various factors of the adhesive system for their fibrosis-inducing effect. We were able to confirm that no additional fibrosis-promoting effect originates from the fibrin clot as a supply barrier.

The influence of fibronectin on the fibrosing of a nerve anastomosis in the rat

“…High concentrations of fibrinogen are necessary in fibrin adhesives and cannot be called in question. After studying the influence of the fibrin clot [10], aprotinin [28], thrombin [9], and Factor XIII [11], the objective of this study was to examine the effect of fibronectin on fibrosis.…”