Fucoxanthin Ameliorates Oxidative Stress and Airway Inflammation in Tracheal Epithelial Cells and Asthmatic Mice

Wu, Shih-Chung; Liou, Chian-Jiun; Chen, Ya Ling; Cheng, Shu-Chen; Huang, Wen‐Chung

doi:10.3390/cells10061311

Cited by 22 publications

(21 citation statements)

References 53 publications

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“…In the case of HFD-induced hepatic inflammation (non-alcoholic steatohepatitis, NASH) in mice, fucoxanthin diet decreased the mRNA expression of inflammatory cytokines (IL-1β, IL-6, TNFα) and chemokine (MCP1). Fucoxanthin also extenuated MCP-1, CCL5, IL-8I, and Th2 (L-4, IL-5 and IL-13) expressions in ovalbumin-activated asthmatic mice [ 43 ]. Apart from brown macroalgae, fucoxanthin extracted from diatoms was also found to inhibit the NF-κB pathway in both the LPS-activated septic mouse model and macrophage 264.7 cells [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…In a similar study with the asthma model conducted by Yang et al [ 32 ], fucoxanthin effectively decreased ROS and subsequent inflammatory cytokine releases through antioxidant enzyme activity in bronchoalveolar lavage fluid. Recently, fucoxanthin has been isolated from brown algae and assessed for bronchial asthma in two different model systems, inflammatory human tracheal epithelial BEAS-2B cells and OVA-sensitized mice, it significantly decreased monocyte cell adherence, ROS, pro-inflammatory cytokines in vitro, and inhibited hyperresponsiveness, Th2 cytokine production, and eosinophil infiltration in the lungs in vivo, respectively [ 43 ]. However, the particulate matter (PM)-induced respiratory disease model was found nowhere in the recent studies; since air pollution and its consequences in respiratory complications are a growing concern globally.…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights

et al. 2022

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Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights

et al. 2022

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“…Asthmatic mice treated with SG had reduced eosinophil infiltration of the lungs compared with their OVA-sensitized untreated counterparts ( Figure 2 A,B). Next, a lung biopsy was stained with PAS solution to observe goblet cell hyperplasia in the trachea of mice [ 27 ]. The PAS staining results showed remarkably upregulated tracheal goblet cell hyperplasia in the OVA-sensitized group.…”

Section: Resultsmentioning

confidence: 99%

Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model

Wang

Huang

Chen

et al. 2022

IJMS

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Sophoraflavanone G (SG), isolated from Sophora flavescens, has anti-inflammatory and anti-tumor bioactive properties. We previously showed that SG promotes apoptosis in human breast cancer cells and leukemia cells and reduces the inflammatory response in lipopolysaccharide-stimulated macrophages. We investigated whether SG attenuates airway hyper-responsiveness (AHR) and airway inflammation in asthmatic mice. We also assessed its effects on the anti-inflammatory response in human tracheal epithelial cells. Female BALB/c mice were sensitized with ovalbumin, and asthmatic mice were treated with SG by intraperitoneal injection. We also exposed human bronchial epithelial BEAS-2B cells to different concentrations of SG to evaluate its effects on inflammatory cytokine levels. SG treatment significantly reduced AHR, eosinophil infiltration, goblet cell hyperplasia, and airway inflammation in the lungs of asthmatic mice. In the lungs of ovalbumin-sensitized mice, SG significantly promoted superoxide dismutase and glutathione expression and attenuated malondialdehyde levels. SG also suppressed levels of Th2 cytokines and chemokines in lung and bronchoalveolar lavage samples. In addition, we confirmed that SG decreased pro-inflammatory cytokine, chemokine, and eotaxin expression in inflammatory BEAS-2B cells. Taken together, our data demonstrate that SG shows potential as an immunomodulator that can improve asthma symptoms by decreasing airway-inflammation-related oxidative stress.

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“…THP-1 cells were incubated with calcein-AM (Sigma). Subsequently, the A549 and THP-1 cells (green fluorescent) were cocultured to assay THP-1 adhesion by fluorescence microscopy (Olympus) [ 18 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury

Huang

Chen

et al. 2021

Mediators of Inflammation

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Tomatidine, which is isolated from green tomato, can ameliorate inflammation and oxidative stress in cells and animal experiments and has been shown to improve airway inflammation in a murine model of asthma. Here, we investigated whether tomatidine can ameliorate acute lung injury in mice. Mice were given tomatidine by intraperitoneal injection for 7 consecutive days, and then, lung injury was induced via intratracheal instillation of lipopolysaccharide (LPS). Tomatidine reduced inflammatory cytokine expressions in bronchoalveolar lavage fluid (BALF), attenuated neutrophil infiltration in the BALF and lung tissue, increased superoxide dismutase activity and glutathione levels, and alleviated myeloperoxidase expression in the lung tissue of mice with lung injury. Tomatidine also decreased inflammatory cytokine and chemokine gene expression in inflammatory lungs and attenuated the phosphorylation of mitogen-activated protein kinase and nuclear factor kappa B. Furthermore, tomatidine enhanced the production of heme oxygenase-1, decreased the secretion of inflammatory cytokines and chemokines in LPS-stimulated lung epithelial cells, and attenuated THP-1 monocyte adhesion. Our findings suggest that tomatidine attenuates oxidative stress and inflammation, improving acute lung injury in mice.

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Fucoxanthin Ameliorates Oxidative Stress and Airway Inflammation in Tracheal Epithelial Cells and Asthmatic Mice

Cited by 22 publications

References 53 publications

A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights

A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights

Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model

Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury

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