Fucoxanthin: A promising compound for human inflammation-related diseases

Liu, Mingjun; Li, Wenwen; Chen, Ying; Wan, Xianyao; Wang, Jia

doi:10.1016/j.lfs.2020.117850

Cited by 72 publications

(45 citation statements)

References 97 publications

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“…A recent study also reports the potential protective effect of fucoxanthin on several inflammation-related diseases, due to fucoxanthin's strong antioxidant capacity and gut microbiota regulation. Some of the important molecules to this regulation include Nrf2, cAMP response element binding protein, extracellular signal-regulated kinase, adenosine monophosphate (AMP)-dependent protein kinase, Akt serine/ threonine kinase/phosphatidylinositol-3-kinase, and peroxisome proliferator-activatedreceptorγcoactivator-1α (M. Liu et al, 2020).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries

Lourenço-Lopes

Fraga-Corral

Carpena

et al. 2021

Trends in Food Science & Technology

107

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries

Lourenço-Lopes

Fraga-Corral

Carpena

et al. 2021

Trends in Food Science & Technology

107

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“…Fucoxanthin, a carotenoid isolated from natural plants such as seaweeds and microalgae, is considered a potent antioxidant [ 160 ]. Several studies show that fucoxanthin exerts various pharmacological activities such as antioxidation, anti-inflammation, anticancer, and health protection effects [ 161 ].…”

Section: The Potential Therapy Of Phytochemicals As Nrf2 Activators I...mentioning

confidence: 99%

Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

Yong

Pan

et al. 2022

Oxidative Medicine and Cellular Longevity

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Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal function of the brain seriously. Its clinical symptoms manifest as behavioral impairment, cognitive decline, communication difficulties, etc. The pathophysiological mechanisms of TBI are complex and involve inflammatory response, oxidative stress, mitochondrial dysfunction, blood-brain barrier (BBB) disruption, and so on. Among them, oxidative stress, one of the important mechanisms, occurs at the beginning and accompanies the whole process of TBI. Most importantly, excessive oxidative stress causes BBB disruption and brings injury to lipids, proteins, and DNA, leading to the generation of lipid peroxidation, damage of nuclear and mitochondrial DNA, neuronal apoptosis, and neuroinflammatory response. Transcription factor NF-E2 related factor 2 (Nrf2), a basic leucine zipper protein, plays an important role in the regulation of antioxidant proteins, such as oxygenase-1(HO-1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), and glutathione peroxidase (GPx), to protect against oxidative stress, neuroinflammation, and neuronal apoptosis. Recently, emerging evidence indicated the knockout (KO) of Nrf2 aggravates the pathology of TBI, while the treatment of Nrf2 activators inhibits neuronal apoptosis and neuroinflammatory responses via reducing oxidative damage. Phytochemicals from fruits, vegetables, grains, and other medical herbs have been demonstrated to activate the Nrf2 signaling pathway and exert neuroprotective effects in TBI. In this review, we emphasized the contributive role of oxidative stress in the pathology of TBI and the protective mechanism of the Nrf2-mediated oxidative stress response for the treatment of TBI. In addition, we summarized the research advances of phytochemicals, including polyphenols, terpenoids, natural pigments, and otherwise, in the activation of Nrf2 signaling and their potential therapies for TBI. Although there is still limited clinical application evidence for these natural Nrf2 activators, we believe that the combinational use of phytochemicals such as Nrf2 activators with gene and stem cell therapy will be a promising therapeutic strategy for TBI in the future.

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“…Promotion of Nrf2 and SOD and suppression of TNF-α action were implicated in ameliorating pathogen-associated molecular pattern-induced inflammation by FX [302]. A recent review reported that signaling pathways like PI3K/AKT/Nrf2, ERK, AMPK/AKT/cAMP response element binding protein (CREB)/peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), and Nrf2-autophagy were involved in FX-induced anti-inflammatory response [303]. Figure 9 presents the mechanism of Nrf2-ARE activation by FX.…”

Section: Fucoxanthin (Fx)mentioning

confidence: 99%

Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

et al. 2021

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ROS, RNS, and carcinogenic metabolites generate excessive oxidative stress, which changes the basal cellular status and leads to epigenetic modification, genomic instability, and initiation of cancer. Epigenetic modification may inhibit tumor-suppressor genes and activate oncogenes, enabling cells to have cancer promoting properties. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that in humans is encoded by the NFE2L2 gene, and is activated in response to cellular stress. It can regulate redox homoeostasis by expressing several cytoprotective enzymes, including NADPH quinine oxidoreductase, heme oxygenase-1, UDP-glucuronosyltransferase, glutathione peroxidase, glutathione-S-transferase, etc. There is accumulating evidence supporting the idea that dietary nutraceuticals derived from commonly used fruits, vegetables, and spices have the ability to produce cancer chemopreventive activity by inducing Nrf2-mediated detoxifying enzymes. In this review, we discuss the importance of these nutraceuticals in cancer chemoprevention and summarize the role of dietary terpenoids in this respect. This approach was taken to accumulate the mechanistic function of these terpenoids to develop a comprehensive understanding of their direct and indirect roles in modulating the Keap1-Nrf2-ARE signaling system.

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Fucoxanthin: A promising compound for human inflammation-related diseases

Cited by 72 publications

References 97 publications

Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries

Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries

Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

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