Fucoxanthin, a Marine Carotenoid Present in Brown Seaweeds and Diatoms: Metabolism and Bioactivities Relevant to Human Health

Peng, Juan; Yuan, Jianping; Wu, Chou-Fei; Wang, Jiang-Hai

doi:10.3390/md9101806

Cited by 648 publications

(480 citation statements)

References 98 publications

(215 reference statements)

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“…Our findings also suggest that the effects of O. aurita intake could be related to a synergistic effect between EPA and other microalgal bioactive compounds, such as pigments, fibers, and phytosterols, which are known to have beneficial effects on human health (Lattimer et al, 2010;Peng et al, 2011).…”

Section: Resultsmentioning

confidence: 76%

Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases

Mimouni

Ulmann

Haimeur

et al. 2015

OCL

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-Marine microalgae are photosynthetic microorganisms producing numerous bioactive molecules of interest for health and disease care such as lipids rich in omega-3 fatty acids -as eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3)-and carotenoids (e.g., β-carotene, fucoxanthin, astaxanthin). It has already been shown that these molecules, individually used, are benefic in the prevention of diseases such as those associated with the cardiovascular risks, but also in some carcinomas. When these molecules are combined, synergistic effects may be observed. Microalgae, as a dietary supplement, can be used to study these synergistic effects in animal models in which dyslipidemia can be induced by a nutrition treatment. Different marine microalgae of interest are studied in this context to determine their potential effect as an alternative source to marine omega-3 rich fish oils, actually widely used for human health. Actually, the pharmaceutical and nutrition industries are developing health research programs involving microalgae, trying to limit the dramatic reduction of fish stocks and the associated pollution in the marine environment. The aim of this review is threefold: (1) to present research on lipids, particularly long chain polyunsaturated fatty acids, as components of marine microalgae used as food supplements; (2) to present the health benefits of some microalgae or their extracts, in particular in the prevention of cardiovascular diseases and (3) to highlight the role of Odontella aurita, a marine microalga rich in EPA used as food supplement with the aim of preventing cardiovascular diseases.Keywords: Microalgae / Odontella aurita / omega-3 polyunsaturated fatty acids / food supplement / cardiovascular diseases Résumé -Microalgues marines utilisées comme compléments alimentaires et leur rôle dans la prévention des maladies cardiovasculaires. Les microalgues marines sont des micro-organismes photosynthétiques produisant de nombreuses molécules bioactives d'intérêt dans le domaine de la santé, tels que des lipides riches en acides gras oméga-3, comme l'acide eicosapentaénoïque (EPA, 20 :5 n-3) et l'acide docosahexaénoïque (DHA, 22 :6, n-3), et des caroténoïdes (par exemple, le β-carotène, la fucoxanthine, l'astaxanthine). Il a déjà été démontré que ces molécules ont un effet positif dans la prévention de maladies notamment celles qui sont associées au système cardiovasculaire, mais aussi dans certains carcinomes. Lorsque ces molécules sont combinées, des effets synergiques peuvent être observés. Les microalgues, utilisées en tant que compléments alimentaires, peuvent contribuer à étudier les effets synergiques de ces composés chez des modèles animaux pour lesquels apparaît une dyslipidémie d'origine nutritionnelle. Différentes microalgues marines sont utilisées dans ce contexte afin de déterminer leur potentiel d'action et de rechercher une source de lipides alternative aux huiles de poissons, ces dernières étant largement utilisées dans le domaine de la santé humaine en ...

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Section: Resultsmentioning

confidence: 76%

Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases

Mimouni

Ulmann

Haimeur

et al. 2015

OCL

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“…Heo et al (2008) have reported the restorative and protective effects of fucoxanthin against H 2 O 2 induced oxidative stress and associated damage. Ax and fucoxanthin (and its metabolites including FuOH) are known to exert antioxidant effect by scavenging superoxide anion and reducing active intermediates as well as up-regulating the activity of antioxidant enzymes in addition to inhibiting molecules such as NF-κB, NO, COX-2 (Augusti et al 2008;Kim et al 2009, Peng et al 2011). …”

Section: Resultsmentioning

confidence: 99%

Does squalene alter the antioxidant potential of astaxanthin and fucoxanthinol? In vitro evidence in RAW 264.7 cells, a murine macrophage

et al. 2015

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Astaxanthin (Ax) and fucoxanthin/fucoxanthinol (FuOH) are marine xanthophylls exhibiting anti-oxidant effects. Squalene (SQ) is a triterpenoid and is a precursor of sterols. This study aimed to determine if SQ can improve the effect of Ax/FuOH on lipid peroxidation. RAW 264.7 cells were treated with different concentrations of Ax, FuOH and SQ and corresponding rate of cell survival was noted. In addition,combination groups -Ax + SQ and FuOH + SQ-were also run. Cells treated with Ax, FuOH, SQ, Ax + SQ and FuOH + SQ were stimulated with lipopolysaccharide and lipid hydroperoxides were estimated. Results showed that 5 μM Ax, 2 μM FuOH and 10 μM SQ supported cell survival. In presence of SQ, cell viability improved for higher concentrations of FuOH (5, 10 μM). Lipid hydroperoxides were supressed by Ax, FuOH, Ax + SQ and FUOH +SQ and were significantly lower in Ax + SQ, indicating the synergistic effect of Ax and SQ. To conclude, combination of Ax with SQ enhances its ability to supress lipid peroxidation while with FuOH, SQ attenuates the toxic effect at higher doses. Moreover, this is the first time that the combined effect of SQ and carotenoids has been studied and reported.

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“…Среди многих видов Bacillariophyta особый интерес для исследователей представляет Cylindrotheca closterium, поскольку она обладает рядом уникальных свойств. В составе ее фотосинтетического аппарата содер-жание фукоксантина приблизительно равно 78 % общего количества каротиноидов (Peng et al, 2011), что составляет 1,7 % сухой биомассы.…”

Section: Introductionunclassified

The medium for intensive culture of the diatom Cylindrotheca closterium (Ehrenb.) Reimann et Lewin (Bacillariophyta)

Ryabushko¹,

Zheleznova²,

Gevorgiz³

et al. 2016

Algologia

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Fucoxanthin, a Marine Carotenoid Present in Brown Seaweeds and Diatoms: Metabolism and Bioactivities Relevant to Human Health

Cited by 648 publications

References 98 publications

Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases

Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases

Does squalene alter the antioxidant potential of astaxanthin and fucoxanthinol? In vitro evidence in RAW 264.7 cells, a murine macrophage

The medium for intensive culture of the diatom Cylindrotheca closterium (Ehrenb.) Reimann et Lewin (Bacillariophyta)

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