Fucosyltransferase 2 induced epithelial-mesenchymal transition via TGF-β/Smad signaling pathway in lung adenocarcinaoma

Deng, Guoqing; Chen, Lvao; Zhang, Yuqi; Fan, Sairong; Li, Wencan; Lü, Jianxin; Chen, Xiaoming

doi:10.1016/j.yexcr.2018.07.026

Cited by 17 publications

(16 citation statements)

References 31 publications

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“…Moreover, FUT2 could enhance the cell migration and invasion of ADC cell lines and might promote ADC metastasis through the EMT initiated by TGF-β/Smad signaling. The results indicated that FUT2 is associated with ADC development and it would be a potential biomarker and therapeutic target of ADC (47, 48).…”

Section: Aberrant Fucosylation In Lung Cancermentioning

confidence: 96%

The Function of Fucosylation in Progression of Lung Cancer

Jia

Zhang

et al. 2018

Front. Oncol.

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Lung cancer is a disease that influences human health and has become a leading cause of cancer mortality worldwide. However, it is frequently diagnosed at the advanced stage. It is necessary by means of biology to identify specific lung tumor biomarkers with high sensitivity. Glycosylation is one of the most important post-translational modifications and is related to many different diseases. It is involved in numerous essential biological processes, such as cell proliferation, differentiation, migration, cell-cell integrity and recognition, and immune modulation. However, little was known about deregulation of glycosylation in lung cancer and contribution to tumor–microenvironment interactions. Among the numerous glycosylations, fucosylation is the most common modification of glycoproteins and glycosylated oligosaccharides. Increased levels of fucosylation have been detected in various pathological conditions, as well as in lung cancer. In this article, we reviewed the role of fucosylation in lung cancer. We highlighted some of the fucosylation alterations currently being pursued in sera or tissues of lung cancer patients. Moreover, we elaborated on the regulation mechanism of fucosylation in proliferative invasion and metastasis of lung tumor cells. In summary, alterations in fucosylation provide potential biomarkers and therapeutic targets in lung cancer.

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Section: Aberrant Fucosylation In Lung Cancermentioning

confidence: 96%

The Function of Fucosylation in Progression of Lung Cancer

Jia

Zhang

et al. 2018

Front. Oncol.

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“…In colon cancer cells undergoing EGF/bFGFinduced EMT, FUT2, one of the two fucosyltransferases which synthesize the H antigen (Figure 3) was down-regulated, suggesting its EMT-preventing role [87]. By contrast, in lung adenocarcinoma, FUT2 supported TGF-β-induced EMT, in that its KO resulted in increased E-cadherin expression and decreased expression of EMT markers [88]. The involvement of FUT4, which mainly elaborates the Le y antigen, in EMT was supported by some observations.…”

Section: Fucosylationmentioning

confidence: 99%

Glycobiology of the Epithelial to Mesenchymal Transition

2021

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Glycosylation consists in the covalent, enzyme mediated, attachment of sugar chains to proteins and lipids. A large proportion of membrane and secreted proteins are indeed glycoproteins, while glycolipids are fundamental component of cell membranes. The biosynthesis of sugar chains is mediated by glycosyltransferases, whose level of expression represents a major factor of regulation of the glycosylation process. In cancer, glycosylation undergoes profound changes, which often contribute to invasion and metastasis. Epithelial to mesenchymal transition (EMT) is a key step in metastasis formation and is intimately associated with glycosylation changes. Numerous carbohydrate structures undergo up- or down-regulation during EMT and often regulate the process. In this review, we will discuss the relationship with EMT of the N-glycans, of the different types of O-glycans, including the classical mucin-type, O-GlcNAc, O-linked fucose, O-linked mannose and of glycolipids. Finally, we will discuss the role in EMT of galectins, a major class of mammalian galactoside-binding lectins. While the expression of specific carbohydrate structures can be used as a marker of EMT and of the propensity to migrate, the manipulation of the glycosylation machinery offers new perspectives for cancer treatment through inhibition of EMT.

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“…Transforming growth factor beta (TGF-β), which played an important role in cell proliferation, differentiation, embryogenesis and morphogenesis, is thought to be a main pathway of the EMT process in cancer [40]. In classic TGF-β/Smad signaling, TGF-β ligand binded to the type II TGF-β receptor (TβRII) on the cell membrane to form the TGF-β/TβRII complex to activate the type I TGF-β receptor (TβRI) [41,42]. Phosphorylation of TβRI activated phosphorylation of Smad2 and Smad3 in cytoplasm [43].…”

Section: Discussionmentioning

confidence: 99%

ADNP prompts the cisplatin-resistance of bladder cancer via TGF-β-mediated epithelial-mesenchymal transition (EMT) pathway

Xie¹,

Zhu²,

Zang³

et al. 2021

J. Cancer

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Activity-dependent neuroprotective protein (ADNP) is vital for embryonic development and brain formation. Besides, the upregulated expression of ADNP enhances tumorigenesis in some human tumors like bladder cancer (BC). However, the potential roles of ADNP in drug resistance and the related mechanisms in BC is unknown. We performed this study to elucidate the influence of ADNP in the chemoresistance of BC and tried to explore the underlying molecular mechanism. The expressions of ADNP in BC from progression and non-progression patient specimens were measured by quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC). In vitro experiments including colony formation, cell counting kit-8 (CCK-8), wound healing, and in vivo tumorigenesis assay were performed to explore the effects of ADNP on chemoresistance of BC. The impacts of ADNP on TGF-β/Smad signaling pathways were explored by western blot. Our results showed that the expression of ADNP mRNA and protein were significantly upregulated in BC tissues of the patients who suffered tumor-progression via RT-PCR and western blot. Cox regression survival analysis revealed that patients with high ADNP expression closely linked to shorter tumor-free survival. ADNP downregulation in BC showed more sensitive to cisplatin in vivo, while ADNP overexpression showed the opposite results. Additionally, we confirmed that ADNP promoted cell migration and EMT, thereby inducing cisplatin resistance, which may be related to TGF-β / Smad signaling pathway.

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Fucosyltransferase 2 induced epithelial-mesenchymal transition via TGF-β/Smad signaling pathway in lung adenocarcinaoma

Cited by 17 publications

References 31 publications

The Function of Fucosylation in Progression of Lung Cancer

The Function of Fucosylation in Progression of Lung Cancer

Glycobiology of the Epithelial to Mesenchymal Transition

ADNP prompts the cisplatin-resistance of bladder cancer via TGF-β-mediated epithelial-mesenchymal transition (EMT) pathway

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