Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

Weelden, Geert van; Bobinski, M.; Okła, Karolina; Weelden, Willem Jan van; Romano, Andrea; Pijnenborg, Johanna M.A.

doi:10.3390/md17010032

Cited by 221 publications

(165 citation statements)

References 197 publications

(245 reference statements)

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“…Fucus evanescens, Sargassum sp. (Figure 9), Saccharina Japonica was reported to inhibit proliferation and metastasis, and inducing apoptosis in vitro [160]. Undaria pinnatifida acted on ERK1/2 MAPK and p38, PI3K/Akt signaling, F. evanescens increased metastatic activity of cyclophosphamide and showed cytolytic activity of natural killer cells in 2 different studies and F. vesiculosus decreased NF-κB in LLC [161].…”

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 95%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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Section: Cancer Prevention and Tumor Controlmentioning

confidence: 95%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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“…One of the reasons is the highly complex chemical structure of Fucoidan, which varies depending on its biological origin. These differences are suggested to greatly affect its potency [54].…”

Section: Macroalgaementioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. Interestingly, a large number of these compounds exert excellent antitumoral properties and have been developed as promising anticancer drugs that have later been approved or are currently under validation in clinical trials. However, due to the high need for these compounds, new methodologies ensuring its sustainable supply are required. Also, optimization of marine bioactives is an important step for their success in the clinical setting. Such optimization involves chemical modifications to improve their half-life in circulation, potency and tumor selectivity. In this review, we outline the most promising marine bioactives that have been investigated in cancer models and/or tested in patients as anticancer agents. Moreover, we describe the current state of development of anticancer marine compounds and discuss their therapeutic limitations as well as different strategies used to overcome these limitations. The search for new marine antitumoral agents together with novel identification and chemical engineering approaches open the door for novel, more specific and efficient therapeutic agents for cancer treatment.

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“…This structure is highly dependent on the algae's species. Due to the complex structure, especially due to branching, it is very difficult to study the whole molecule [54].…”

Section: Fucoidansmentioning

confidence: 99%

“…While, glycuronogalactofucans are composed of linear chains of (1,4)-d-galactose branched at C 5 with l-fuco-syl-3-sulfateoroccasionallyuronicacid [56]. This backbone consists of (1 → 3)-linked α-l-fucopyranose residues (type 1, Figure 6A) or alternating (1 → 3)-linked α-l-fucopyranose, (1 → 4)-linked α-l-fucopyranose residues (type 2, Figure 6B), and fucose and sulfate branching (Figure 6C) [54].…”

Section: Figurementioning

confidence: 99%

“…Structure of fucoidans[54].Major Natural Vegetation in Coastal and Marine Wetlands: Edible Seaweeds DOI: http://dx.doi.org/10.5772/intechopen.88303 metal ions and obtained very viscous solutions when hydrated. This water absorption property makes alginate suitable for different applications specially in biological studies with potential application as anti-coagulant, anti-tumor, anti-viral and anti-oxidant[55,60,61].…”

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confidence: 99%

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Major Natural Vegetation in Coastal and Marine Wetlands: Edible Seaweeds

Babahan¹,

Kirim²,

Mehr³

2020

Plant Communities and Their Environment

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For thousands of years, seaweeds grown in coastal and marine have been used as food, materials and medicines by the people. Edible seaweeds directly consumed, especially in Asian, are used for preparing food due to the their components containing minerals, essential trace elements, and various natural compounds. At the last decades, they have been getting more and more attention in food and pharmaceutical industries because of their biological activities such as anti-cancer, anti-obesity, anti-diabetes, anti-microbial, and anti-oxidant activity. Therefore, in the present study, we have worked on to understand the structure of edible seaweeds. It is worthy to mention that they can be considered as source of some proteins, polyunsaturated fatty acids, minerals, vitamins, dietary fibers, antioxidants, and phytochemicals.

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Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

Cited by 221 publications

References 197 publications

Seaweeds: An Extensive Review of Medicinal Values

Seaweeds: An Extensive Review of Medicinal Values

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Major Natural Vegetation in Coastal and Marine Wetlands: Edible Seaweeds

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