Fucoidan functionalization on poly(vinyl alcohol) hydrogels for improved endothelialization and hemocompatibility

Bioconjugation of a Collagen-Mimicking Peptide Onto Poly(vinyl alcohol) Encourages Endothelialization While Minimizing Thrombosis

“…hyperplasia and thrombosis and potential loss of patency. Studies of compliant PVA biomaterials suggest that the low thrombogenicity of the material makes it a promising vascular graft material (Chaouat et al, 2008;Cutiongco et al, 2015a,b;Jurney et al, 2018;Anderson et al, 2019;Rizwan et al, 2020;Yao et al, 2020). However, in the absence of surface modifications, PVA is unable to support EC attachment and growth.…”

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

“…[279] Some studies also revealed that gamma irradiation increased the blood protein adsorption on stent surface, which increased the risk of thrombus formation and platelet accumulation and activation. [280] The thrombin generation was slightly increased on gamma treated surface, [281] while EC density was significantly increased. [281,282] EO sterilization is suitable for polymer implants, but influences their physicochemical properties.…”

“…[280] The thrombin generation was slightly increased on gamma treated surface, [281] while EC density was significantly increased. [281,282] EO sterilization is suitable for polymer implants, but influences their physicochemical properties. [283] Importantly, EO sterilization can been used for scaffolds modified by active molecules.…”

Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review

“…Hydrogels are 3D structure made up of hydrophilic polymers with high water affinity, whose dissolution is prevented, thanks to the formation of physical or chemical bonds. The polymers constituting such a matrix can be chemically modified in order to introduce new features in the final material, thus allowing the synthesis of hydrogels for different applications, from controlled drug delivery to selective targeting tools or diagnostics such as functionalized polyvinyl alcohol hydrogels with fucoidan for improved endothelialization and hemocompatibility (Yao et al 2020). Fucoidan is a sulfated polysaccharide with anticoagulant and antithrombotic properties, the problem with such a modification was that some mechanical properties were sacrificed.…”