Fucoidan as a marine-origin prebiotic modulates the growth and antibacterial ability of Lactobacillus rhamnosus

Zhu, Yanli; Liu, Lubin; Sun, Zhongyang; Ji, Yanjing; Wang, Danyang; Mei, Li; Shen, Peili; Li, Zhixin; Tang, Shang; Zhang, Hui; Zhou, Qihui; Deng, Jing

doi:10.1016/j.ijbiomac.2021.03.065

Cited by 48 publications

(31 citation statements)

References 46 publications

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“…Similar to many other natural extracts, quercetin can exert antibacterial activity to a certain extent ( Jaisinghani, 2017 ; Hao et al, 2021 ; Zhu et al, 2021 ). Although these natural extracts may differ in their antimicrobial mechanism, most of them induce bacterial lysis via cell membrane damage.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Rejuvenates Sensitization of Colistin-Resistant Escherichia coli and Klebsiella Pneumoniae Clinical Isolates to Colistin

et al. 2021

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Colistin is being considered as “the last ditch” treatment in many infections caused by Gram-negative stains. However, colistin is becoming increasingly invalid in treating patients who are infected with colistin-resistant Escherichia coli (E. coli) and Klebsiella Pneumoniae (K. pneumoniae). To cope with the continuous emergence of colistin resistance, the development of new drugs and therapies is highly imminent. Herein, in this work, we surprisingly found that the combination of quercetin with colistin could efficiently and synergistically eradicate the colistin-resistant E. coli and K. pneumoniae, as confirmed by the synergy checkboard and time-kill assay. Mechanismly, the treatment of quercetin combined with colistin could significantly downregulate the expression of mcr-1 and mgrB that are responsible for colistin-resistance, synergistically enhancing the bacterial cell membrane damage efficacy of colistin. The colistin/quercetin combination was notably efficient in eradicating the colistin-resistant E. coli and K. pneumoniae both in vitro and in vivo. Therefore, our results may provide an efficient alternative pathway against colistin-resistant E. coli and K. pneumoniae infections.

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Section: Discussionmentioning

confidence: 99%

Quercetin Rejuvenates Sensitization of Colistin-Resistant Escherichia coli and Klebsiella Pneumoniae Clinical Isolates to Colistin

et al. 2021

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“…Though the presence of ROS would worsen the condition in OA, ROS is required during the early phase of the antimicrobial ( Ren et al, 2020a ; Ji et al, 2021 ; Wang et al, 2021 ; Zhu et al, 2021 ) and anticancer ( Ren et al, 2020b ) progress for osteomyelitis and osteosarcomas. Particular emphasis is placed on the ROS-mediated photochemical and molecular mechanisms that give rise to the establishment of photothermal therapy as a treatment of highly resistant diseases, especially invasive and metastatic tumors.…”

Section: Reactive Oxygen Species-responsive Biomaterials For Treating Bone-related Diseasesmentioning

confidence: 99%

Reactive Oxygen Species (ROS)-Responsive Biomaterials for the Treatment of Bone-Related Diseases

Ren

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are the key signaling molecules in many physiological signs of progress and are associated with almost all diseases, such as atherosclerosis, aging, and cancer. Bone is a specific connective tissue consisting of cells, fibers, and mineralized extracellular components, and its quality changes with aging and disease. Growing evidence indicated that overproduced ROS accumulation may disrupt cellular homeostasis in the progress of bone modeling and remodeling, leading to bone metabolic disease. Thus, ROS-responsive biomaterials have attracted great interest from many researchers as promising strategies to realize drug release or targeted therapy for bone-related diseases. Herein, we endeavor to introduce the role of ROS in the bone microenvironment, summarize the mechanism and development of ROS-responsive biomaterials, and their completion and potential for future therapy of bone-related diseases.

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“…To further improve the bactericidal characteristics, the combination of nano-ZnO and other antimicrobial agents has been extensively studied. Recently, surface functionalization with organic antimicrobial agents has also been considered to obtain antibacterial properties on Ti surfaces [ 126 , 127 ]. Antibacterial N-halamine polymers and related coatings have been widely studied in the past decade because of their strong broad-spectrum antibacterial activity against microorganisms, long-term chemical stability, renewability, biosafety, environmental friendliness and low cost [ 78 ].…”

Section: Antimicrobial Activity Of Nano-zno Modified Ti Implantsmentioning

confidence: 99%

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Wang

et al. 2021

J Nanobiotechnol

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Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the viewpoints of fundamental research and practical applications. Also, numerous studies have been carried out to fine-tune the micro/nanostructures of Ti and/or incorporate chemical elements to improve overall implant performance. Zinc oxide nanoparticles (nano-ZnO) are well-known for their good antibacterial properties and low cytotoxicity along with their ability to synergize with a variety of substances, which have received increasingly widespread attention as biomodification materials for implants. In this review, we summarize recent research progress on nano-ZnO modified Ti-implants. Their preparation methods of nano-ZnO modified Ti-implants are introduced, followed by a further presentation of the antibacterial, osteogenic, and anti-corrosion properties of these implants. Finally, challenges and future opportunities for nano-ZnO modified Ti-implants are proposed. Graphical Abstract

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Fucoidan as a marine-origin prebiotic modulates the growth and antibacterial ability of Lactobacillus rhamnosus

Cited by 48 publications

References 46 publications

Quercetin Rejuvenates Sensitization of Colistin-Resistant Escherichia coli and Klebsiella Pneumoniae Clinical Isolates to Colistin

Quercetin Rejuvenates Sensitization of Colistin-Resistant Escherichia coli and Klebsiella Pneumoniae Clinical Isolates to Colistin

Reactive Oxygen Species (ROS)-Responsive Biomaterials for the Treatment of Bone-Related Diseases

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

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